Head of Molecular Liver Pathophysiology Unit Department of Life Sciences – University of Trieste, ITALY

Wednesday 28 April 2021 |12:00 noon – ICGEB Trieste, ITALY

New avenues in disease modeling and regenerative medicine of the enterohepatic system

Host: G. Del Sal

Dr. Sorrentino’s research is oriented at understanding the fundamental principles that regulate epithelial stem cell homeostasis, with the ultimate goal of translating this knowledge to design innovative disease models and regenerative medicine therapies. In particular, he is interested in understanding how nutritional cues coordinate metabolic communication within the enterohepatic system to control stemness and disease development. These basic biological questions are approached by combining mouse models, tissue engineering, and 3D organotypic cultures. The seminar will discuss mechanisms of nutrient sensing in intestinal stem cells, innovative strategies to derive clinical grade hepatic organoids as well as multidisciplinary approaches to model chronic liver diseases ex vivo.