Thursday, 28 June 2018 |12:00 noon

Institute of Human Genetics, The International Centre for Life , Newcastle University, UKNA splicing regulation and male infertility

RNA splicing regulation and male infertility

(Host: E. Buratti)

In my group we are investigating gene expression control, particularly at the level of RNA splicing regulation, and how this contributes to both normal health and disease. One particular disease I have been interested in ever since I was a postdoc is male infertility. This stemmed from the discovery of a family of RNA binding proteins that are expressed in the germline. These were discovered as they were deleted in some infertile men, but their functions have been so far largely unknown. In this seminar I will cover our recent work to find out what these RNA binding proteins are doing in the germline and the surprising answers we have got so far.