Principal Scientist – Chairman, Cell Biology Department Research & Innovation, Riyadh King Faisal Specialist Hospital & Research Centre – Head – Unità di Ingegneria Tissutale, Chair Elect – ESC WG on Cellular Biology of the Heart, Centro Cardiologico Monzino, IRCCS, Milan, ITALY
Epigenetic senescence and calcification of the aortic valve: a long journey from chromatin remodeling to nuclear mechanics
Host: S. Zacchigna
The calcification of the aortic valve is one of the most rapidly increasing cardiac pathologies. It is driven by an atherosclerosis-like inflammatory process and is mediated by transformation of the valve resident cells, the so-called valve interstitial cells into calcific nodule secretory cells. Several factors are responsible for pathologic evolution of the valve interstitial cells, including alterations in the epigenetic landscape. In the seminar I will present unpublished data linking cellular senescence and epigenetic alterations as a cause of valve interstitial cells calcification. I will also outline the possibility to interfere with calcification process by an epigenetic therapy. I will also describe the implications of epigenetic senescence on alterations of nuclear mechanics and chromatin accessibility.
International Seminar Programme
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