Nyaradzo Chigorimbo Tsikiwa

Group Leader, Infectious Diseases
International Centre for Genetic Engineering and Biotechnology
Wernher and Beit Building (South)
Anzio Road, Observatory 7925
Cape Town, South Africa
E-mail: [email protected]

Education

University of Cape Town (UCT) Ph.D. in Chemical Engineering, 2006
Drug Discovery and Development Centre and UCT, Post-Doctoral fellow, H3D, 2009-2013 

Career History

Since 2023, Group Leader, Infectious Diseases, ICGEB Cape Town, South Africa
2022, Research Co-ordinator, Research Office, University of Cape Town
2020-2023, Senior Research Officer, Division of Medical Virology, University of Cape Town
2014- 2020, Early career Fellow, Division of Immunology, University of Cape Town
2014, Lecturer, Desmond Tutu HIV Centre, University of Cape Town
2009-2013, Senior scientist and Post-Doctoral fellow H3D

Scientific Activity

Our laboratory investigates HIV-1 susceptibility in the genital tract, focusing on myeloid cells which are part of the innate immune response. We use various tools to understand their interactions, responses, and transmission of HIV-1. These tools include systems biology approaches utilising transcriptomic, and proteomic analysis as well as microscopy. We have developed ex vivo tools that allow us to conduct this useful analysis.

Teaching Activity

Previous: First year Health and rehabilitation Biosciences course lecturer, and course convenor (UCT) Clinical management of HIV and TB (UCT and Desmond Tutu HIV foundation)
Lecturer and co-convenor Advanced Immunology course, UCT

Current: Infectious disease and vaccines course (UCT)

Selected Publications

Chigorimbo-Murefu, N.T., Potgieter, M., Dzanibe, S., Gabazana, Z., Buri, G., Chawla, A., Nleya, B., Olivier, A.J., Harryparsad, R., Calder, B. and Garnett, S., 2022. A pilot study to show that asymptomatic sexually transmitted infections alter the foreskin epithelial proteome. Frontiers in Microbiology, 13.

Gray, C.M., O’Hagan, K.L., Lorenzo-Redondo, R., Olivier, A.J., Amu, S., Chigorimbo-Murefu, N., Harryparsad, R., Sebaa, S., Maziya, L., Dietrich, J. and Otwombe, K., 2020. Impact of chemokine CC ligand 27, foreskin anatomy and sexually transmitted infections on HIV-1 target cell availability in adolescent South African males. Mucosal immunology, 13(1), pp.118-127.

Davies, J., Vallejo, A.F., Sirvent, S., Porter, G., Clayton, K., Qumbelo, Y., Stumpf, P., West, J., Gray, C.M., Chigorimbo-Murefu, N.T. and MacArthur, B., 2021. An IRF1-IRF4 Toggle-Switch Controls Tolerogenic and Immunogenic Transcriptional Programming in Human Langerhans Cells. Frontiers in immunology, 12, p.665312.

Bokani Nleya, Yamkela Qumbelo, Nobomi Dontsa, Christen Da Costa, Kyle O’hagan, Clive M. Gray, Nyaradzo T. Chigorimbo-Tsikiwa. Characterisation of potential HIV target Myeloid cells in Foreskin Epithelia. Conference on Retroviruses and Opportunistic Infections 2020.209

K.L., O’Hagan, A.J., Olivier, Sylvie A, N.T.L Chigorimbo-Tsikiwa, J. Dietrich, S. Ferrian, N.N., Mkhize, D., Lewis, H.B., Jaspan, D. Wilson, G. Cianci, M. Dinh, A-L. Williamson, J-A.S., Passmore, F. Chiodi, T.J., Hope, C.M., Gray. C. trachomatis Infection Results in Elevated HIV Target Cell Densities and Differential Chemokine Expression Between the Inner and Outer Foreskin.2018. AIDS Research and Human Retroviruses 34:305-305.

Harryparsad R., Noholoza S., Chigorimbo-Murefu N.T.L., Olivier A.J., Gray C.M. in Hope, T.J.,Douglas D Richman, Mario Stevenson. Encyclopedia of AIDS. 2018

Chigorimbo-Murefu, N.T., Njoroge, M., Louw, S., Mugumbate, G. and Chibale, K., 2013. Drug metabolite generation using a laboratory evolved NADPH independent cytochrome P450: application of in vitro and in silico approaches. Drug metabolism letters, 7(1), pp.68-77.

Louw, S., Njoroge, M., Chigorimbo-Murefu, N. and Chibale, K., 2012. Comparison of electrospray ionisation, atmospheric pressure chemical ionisation and atmospheric pressure photoionisation for the identification of metabolites from labile artemisinin-based anti-malarial drugs using a QTRAP® mass spectrometer. Rapid communications in mass spectrometry: RCM, 26(20), pp.2431-2442.

Chigorimbo-Murefu, N.T., Riva, S. and Burton, S.G., 2009. Lipase-catalysed synthesis of esters of ferulic acid with natural compounds and evaluation of their antioxidant properties. Journal of Molecular Catalysis B: Enzymatic, 56(4), pp.277-282.

Chigorimbo-Murefu NT, Njoroge M, Louw S, Mugumbate G, Chibale K. Drug metabolite generation using a laboratory evolved NADPH independent cytochrome P450: application of in vitro and in silico approaches. Drug Metab Lett. 2013 Mar;7(1):68-77. doi: 10.2174/18723128112069990014.