Ved Prakash Dwivedi

Group Leader, Immunobiology
International Centre for Genetic Engineering and Biotechnology
ICGEB Campus
Aruna Asaf Ali Marg
110 067 New Delhi, INDIA
E-mail: ved@icgeb.res.in
Tel: +91-11-26741358/ 26741361/ 26742357/ 26742360 ext. 427

Education

Career History

University of Calcutta, Kolkata, India, PhD, 2014
Department of Biotechnology, University of Jammu, India, MSc, 2006
University of Allahabad, India, BSc, 2004

Since 2019, Group Leader, Immunobiology Group, International Centre for Genetic Engineering and Biotechnology (ICGEB), New Delhi, India
2015-2019, DST-INSPIRE Faculty, ICGEB New Delhi
2013-2015, Postdoctoral Fellow, University of KwaZulu-Natal, Durban, South Africa

Scientific Activity

Understanding the host protective immune responses during tuberculosis

Selected Publications

Santosh Kumar, Chetan Sharma, Sandeep Rai Kaushik, Ankur Kulshreshta, Shivam Chaturvedi, Ranjan Kumar Nanda, Ashima Bhaskar, Debprasad Chattopadhyay, Gobardhan Das and Ved Prakash Dwivedi. The phytochemical bergenin as an adjunct immunotherapy for tuberculosis in mice. J Biol Chem. 2019 May 24;294(21):8555-8563.

Ved Prakash Dwivedi, Debapriya Bhattacharya, Mona Singh, Ashima Bhaskar, Santosh Kumar, Parveen Sobia, Luc Van Kaer and Gobardhan Das. Allicin enhances anti-mycobacterial activity of macrophages via SAPK/JNK signaling. J Ethnopharmacol. 2018 Dec 8. pii: S0378-8741(18)31763-X. doi: 10.1016/j.jep.2018.12.008. [Epub ahead of print].

Ved Prakash Dwivedi, Debapriya Bhattacharya, Vinod Yadav, Dhiraj Kumar Singh, Santosh Kumar, Mona Singh, Durbadal Ojha, Anand Ranganathan, Luc Van kaer, Debprasad Chattopadhyay and Gobardhan Das (2017) The phytochemical bergenin enhances T helper 1 responses and anti-Mycobacterial immunity by activating the MAP kinase pathway in macrophages. Front Cell Infect Microbiol. 2017: 7: 149.

Dhiraj Kumar Singh, Ved Prakash Dwivedi, Anand Ranganathan, William R Bishai, Luc Van Kaer and Gobardhan Das. Reply to Levis and Rendini. J Infect Dis. 2017 May 1; 215 (9): 1488–1489.

Dhiraj Kumar Singh, Ved Prakash Dwivedi, Anand Ranganathan, William R Bishai, Luc Van Kaer and Gobardhan Das. Blockade of the Kv1.3 K+ channel enhances BCG vaccine efficacy by expanding central memory T lymphocytes. J Infect Dis. 2016 Nov 1; 214 (9): 1456-1464.

Debapriya Bhattacharya* Ved Prakash Dwivedi*, Mona Singh, Vinod Yadav and Gobardhan Das. Understanding the role of Mesenchymal stem cells in infectious diseases: Focus on Tuberculosis, Malaria, Sepsis and HIV. Electronic J Biol; 2016 12: 3.

Durbadal Ojha, Rashmi Das, Parveen Sobia, Ved Prakash Dwivedi, Soma Ghosh, Amalesh Samanta, Debprasad Chattopadhyay. Pedilanthus tithymaloides inhibits HSV infection through the modulation of NF-kB signaling pathway. PLoS One. 2015 Sep 25; 10 (9): e0139338.

Vinod Yadav, Ved Prakash Dwivedi, Debapriya Bhattacharya, Ashwani Mittal, Prashini Moodley and Gobardhan Das. Understanding the Host Epigenetics in Mycobacterium tuberculosis Infection. J Genet Genome Res 2015; 2:1.

Md Aejazur Rahman, Parveen Sobia, Ved Prakash Dwivedi, Pawan Sharma, Prashini Moodley, Luc Van Kaer, William R Bishai and Gobardhan Das. Mycobacterium tuberculosis TlyA negatively regulates Th1 and Th17 differentiation and promotes tuberculosis pathogenesis. J Biol Chem. 2015 Jun 5; 290 (23): 14407-17.

Kuhulika Bhalla, Monika Chugh, Sonali Mehrotra, Sumit Rathore, Sultan Tousif, Ved Prakash Dwivedi, Prem Prakash, Sachin Kumar Samuchiwal, Sushil Kumar, Dhiraj Kumar Singh, Swapnil Ghanwat, Dhiraj Kumar, Gobardhan Das, Asif Mohmmed, Pawan Malhotra and Anand Ranganathan. Host ICAMs play a role in cell invasion by Mycobacterium tuberculosis and Plasmodium falciparum. Nature Commun. 2015 Jan 14; 6: 6049.

Debapriya Bhattacharya, Ved Prakash Dwivedi, Santosh Kumar, Madhava C Reddy, Luc Van Kaer, Prashini Moodley and Gobardhan Das. Simultaneous inhibition of T helper 2 and T regulatory cell differentiation by small molecules enhances Bacillus Calmette-Guerin vaccine efficacy. J Biol Chem. 2014 Nov 28; 289 (48): 33404-11.

Durbadal Ojha, Hemanta Mukherjee, Aditya Jena, Supriya Mondal, Ved Prakash Dwivedi, Keshab C Mondal, Amalesh Samanta, Debprasad Chattopadhyay. In vivo and in vitro anti-inflammatory activity of Odina wodier Roxb, an Indian folk medicine, through inhibition of toll-like receptor 4 signaling pathway. PLoS One. 2014, 9 (8): e104939.

Debapriya Bhattacharya, Ved Prakash Dwivedi, Mamoudou Maiga, Mariama Maiga, Luc Van Kaer, William R Bishai & Gobardhan Das. Small molecule directed immunotherapy against recurrent infection by Mycobacterium tuberculosis. J Biol Chem. 2014 Jun 6; 289 (23): 16508-15.

Debapriya Bhattacharya, Ved Prakash Dwivedi, Gobardhan Das (2013) Revisiting Immunotherapy in Tuberculosis. J Mycobac Dis 2013, 4: e123.

Swagata Ghosh, Hanumantha Rao Kongara, Neel Sarovar Bhavesh, Gobardhan Das, Ved Prakash Dwivedi and Asis Datta. N-acetylglucosamine (GlcNAc) inducible gene, GIG2, is a novel component of GlcNAc metabolism in Candida albicans. Eukaryot Cell. 2014 Jan; 13 (1): 66–76.

Yogesh Singh, Samit Chatterjee, Vandana Kaul, Sultan Tousif, Ved Prakash Dwivedi, Alka Mehra, Luc Van Kaer, Gobardhan Das. Mycobacterium tuberculosis controls microRNA-99b (miR-99b) expression in infected murine dendritic cells to modulate host immunity. J Biol Chem. 2013. Feb 15; 288 (7): 5056- 61.

Ved Prakash Dwivedi, Debapriya Bhattacharya, Samit Chatterjee, Luc Van Kaer, Debprasad Chattopadhyay, William R. Bishai, and Gobardhan Das. Mycobacterium tuberculosis directs T helper 2 cell differentiations by inducing in terleukin-1β production in dendritic cells. J Biol Chem. 2012 Sep 28; 287 (40): 33656-63.

Ramesh Chandra Rai, Ved Prakash Dwivedi, Samit Chatterjee, Durbaka Vijaya Raghava Prasad and Gobardhan Das. Early secretory antigenic target-6 of Mycobacterium tuberculosis: enigmatic factor in pathogen-host interactions. Microbes Infect. 2012 Nov; 14 (13): 1220-6.

Mohd Moin Khan, Samit Chatterjee, Ved Prakash Dwivedi, Nishant Kumar Pandey*, Yogesh Singh, Sultan Tousif, Neel Sarovar Bhavesh, Luc Van Kaer, Jyoti Das, and Gobardhan Das. CD4+T Cell-derived Novel Peptide Thp5 Induces Interleukin-4 Production in CD4+T Cells to Direct T Helper 2 Cell Differentiation. J Biol Chem 2012 Jan 20: 287 (4): 2830–2835.

Ved Prakash Dwivedi, Sultan Tousif, Debapriya Bhattacharya, Durbaka Vijaya Raghava Prasad, Luc Van Kaer, Jyoti Das, and Gobardhan Das. Trans forming growth factor-β protein inversely regulates in vivo differentiation of interleukin-17 (IL-17)-producing CD4+ and CD8+T cells. J Biol Chem. 2012 Jan 27; 287 (5): 2943-7.

Samit Chatterjee, Ved Prakash Dwivedi, Yogesh Singh, Imran Siddiqui, Pawan Sharma, Luc Van Kaer, Debprasad Chattopadhyay and Gobardhan Das. Early secreted antigen ESAT-6 of Mycobacterium tuberculosis promotes protective T helper 17 cell responses in a toll-like receptor-2-dependent manner. PLoS Pathog. 2011 Nov: 7(11): e1002378.

Tarun Kumar Bhatt, Sameena Khan, Ved Prakash Dwivedi, Mudassir Meraj Banday, Arvind Sharma, Anmol Chandele, Noelia Camacho, Lluís Ribas de Pouplana, Yang Wu, Alister G. Craig, Antti Tapani Mikkonen, Alexander Gerd Maier, Manickam Yogavel and Amit Sharma. Malaria parasite tyrosyl-tRNA synthetase secretion triggers pro-inflammatory responses. Nature Commun. 2011 Nov 8; 2: 530.