Queen Square Brain Bank for Neurological Disorders and Department of Neurodegenerative Diseases, Institute of Neurology, University College London , UK
Tuesday 25 June 2019 | 12:00 noon
Current research of neurodegenerative diseases
Host: E. Buratti
The use of post-mortem human brain tissue is vital in understanding the mechanisms underlying neurodegenerative diseases. At Queen Square Brain Bank we actively collect human brain tissue for research, having large tissue banks from various neurodegenerative diseases including Alzheimer’s disease, Parkinson’s disease, Frontotemporal dementia, Progressive supranuclear palsy and many more. The tissue is collected, diagnosed and then utilised in numerous research projects both in house, nationally and internationally. My research is focused around the use of the donated brain tissue: including large clinico-pathological investigations, correlating the clinical symptoms with underlying pathological hallmarks which aids in refining the diagnosis of patients during life. Pathological investigations, biochemical analysis, proteomics and lipidomics are being used to determine the abnormalities observed in the brains. These investigations have lead onto understanding different mechanisms involved in these diseases and which pathways could be targeted for potential treatments.