Two Groups in Trieste operate in the field of cardiovascular disease. The Molecular Medicine Group (Giacca) aims to identify proteins and microRNAs controlling cardiac protection and regeneration that might be exploited for the therapy of heart diseases, The Molecular Cardiology Unit (Loffredo) in the same Group specifically investigates pathways that regulate cardiac ageing. The Cardiovascular Biology Group (Zacchigna) aims to characterise the mechanisms that hamper the formation of new blood vessels in the heart after myocardial infarction and to develop innovative strategies to revascularise ischaemic tissues.
In a collaborative study involving the Molecular Medicine, Cardiovascular Biology and the Tumour Virology groups in Trieste, a major advance was Two fascinating studies involving these Groups in Trieste characterised the potential of microRNAs to promote cardiac regeneration after myocardial infarction in large animals and provided evidence for the repurposing of the anti-psychotic drug Haloperidol for the treatment of fibrotic diseases (Gabisonia et al., 2019, Nature, 7756, 418; Rehman et al. 2019, JCI Insight, 4, 8).