The Translational Bioinformatics group focuses on the development and application of computational biology tools to address research problems in the post-genomic era.
The Group extensively exploited artificial intelligence based techniques for solution of various bioinformatics and cheminformatics research problems. It has developed several web servers for sequence based prediction for important protein families, members of which do not have obvious sequence similarities, conserved motifs and domains- this includes Cyclins (server: CyclinPred), Lipocalins (LipocalinPred), CDK inhibitor proteins (CDKIPred), virulent proteins (VirulentPred) and Fungal Adhesions (FaaPred).
The group has extended the use of SVMs (Support Vector Machine, an Artificial Intelligence-based method), and molecular modeling methods to develop a target-oriented focused library of compounds active against novel P. falciparum PfHslV and 20S proteasome, the newly identified drug targets against the parasite. The laboratory developed SVM based cheminformatics method to predict proliferation inhibitors of P. falciparum. The group actively collaborates with other groups at ICGEB to validate predictions. Some of the previously accomplished projects of the lab include the development of protein sequence databases including- ProtRepeatsDB: a database of different types of protein repeats sequences in genomes, ProtvirDB: a database of protozoan virulent protein sequences. Recently initiated projects include the development of methods and computational pipeline for genome-wide identification of small non-coding RNAs in P. falciparum and plant genomes.
Bioinformatics Web servers and databases (https://bioinfo.icgeb.res.in)
Prediction method for fungal adhesins
A database of protozoan virulent proteins
Prediction method for Lipocalins
Homology modelling of P. falciparum proteins.
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