Recent Scientific Breakthroughs at ICGEB

Spearheading recent scientific breakthroughs at ICGEB, a recent ground-breaking publication in Nature Communications from the Molecular Virology lab has opened the way to more efficient antiviral action. Read more

In a paper in PLoS Neglected Tropical Diseases, Vector Borne Diseases PI Sujatha Sunil and Group show, for the first time, direct binding of Aedes miRNAs to chikungunya virus 3’UTR. In addition, they explain how the miRNA further interacts with other vector factors to regulate virus infection in Aedes cells. Another recent publication in Viruses by the Group appeared as a special issue on chikungunya, also being mentioned in the editorial. This study evaluated pathogenicity of clinical isolates of chikungunya virus(CHIKV) in a mouse model. “Using the most pathogenic virus, we further studied the impact of CHIKV on two age groups using the immunocompetent mice model” the Group comments.

Cytokines and Disease PI Frank Brombacher recently published in PLoS Biology to show how host soluble mediators such as cytokines play a key role in the regulation of the immune response. Forkhead box P3 (Foxp3+) regulatory T (Treg) cells, which are involved in maintaining self-tolerance and immune system homeostasis, are influenced by cytokines, including interleukin-4.

Omics of Algae Group Leader, Pavan Jutur highlights his Group’s recent article in Biotech for Biofuels on qualitative metabolomics, in marine microalgae P. kessleri, that revealed the identification of relevant metabolites in the biosynthesis and degradation of precursor molecules that may have the potential for biofuel production.

Malaria Drug Discovery, Dinkar Sahal’s article on the Discovery of Drugs featured in the 100th issue of the journal Cutting Edge.

We also celebrate Suresh Nair’s media coverage on his publication on Bacterial community structure in the Asian rice gall midge that reveals a varied microbiome rich in proteobacteria.

Molecular Pathology, Emanuele Buratti’s publication on Pompe disease also received the Editor’s Choice award.

Our PIs in Trieste, New Delhi and Cape Town bring their recent findings published in international, peer-reviewed journals, as available on their research pages.