Group leader, Translational Health
ICGEB Laboratories
ICGEB Campus
Aruna Asaf Ali Marg
110 067 New Delhi, INDIA
E-mail: [email protected]
Tel: +91-11-26741358 ext 426
Education
Indian Institute of Technology Kharagpur, India, PhD, 2008
Sambalpur University, School of Life Sciences, Sambalpur, India, MSc, 2001
Career History
Since 2015, Group Leader, Translational Health Group
2009-2015, Staff Research Scientist of the Immunology Group, International Centre for Genetic Engineering and Biotechnology (ICGEB), New Delhi, India.
2007-2009, Research Scientist, ICGEB New Delhi.
Scientific Activity
Our long-term interest is to better understand host-pathogen interaction in tuberculosis disease with major focus on clinical patient based studies for hypothesis building and employ in-vitro and in-vivo model systems for mechanistic and validation studies. The current focus of the group is to elucidate the molecular and cellular details in anaemia of inflammation (iron limitation), immune-senescence (with aging) and chronic inflammation (in diabetes) conditions and their influence on the T cell and dendritic cell (DC) metabolic function to explain tuberculosis susceptibility in in-vivo model systems before correlating with patient data. Understanding inflammation at molecular levels is critical to identifying molecules that could improve perturbed immune-metabolism in tuberculosis for improved bacterial clearance. Our observation on gut microbiome dysbiosis and altered faecal metabolome in tuberculosis patients with respect to controls and in in-vivo model systems will be useful to identify probiotics and postbiotics for nutritional intervention. Overall, the group’s aim is to develop translatable solutions by detailed understanding of tuberculosis disease pathophysiology at the cellular and molecular levels to develop novel adjunct therapeutics, nutritional intervention and easy-to-use disease screening (eNOSE) for better tuberculosis management.
Selected Publications
Akram, S., Thakur, J., Shree, M., Masakapalli, S.K., Nanda, R.K. 2020. Kinetic isotope tracing of glycerol and de novo proteogenic amino acids in Human Lung Carcinoma cells using [13C6]glucose. bioRxiv 2020.10.28.358432; doi: https://doi.org/10.1101/2020.10.28.358432.
Singh, K.V., Prakash, C., Nirala, J.P., Nanda, R.K., Rajamani, P.* 2020. Acute radiofrequency electromagnetic radiation exposures cause neuronal DNA damage and impair neurogenesis in the young adolescent rat brain. bioRxiv 2020.11.07.370627
Sahu, D., Biswal, S.C., Malik, MdZ., Sahu, S., Kaushik, S.R., Sharma, S., Saini, E., Arya, R., Rastogi, A., Sharma, S., Sen, S., Singh, R.K.B., Nanda, R.K., Panda, A.K. 2020. Troxerutin acts on complement mediated inflammation to ameliorate arthritic symptoms in rats. bioRxiv 2020.08.18.253427; doi: https://doi.org/10.1101/2020.08.18.253427
Singh, S., Arya, R., Bargaje, R.R., Das, M.K., Akram, S., Faruquee, HMd., Behera, R.K., Nanda, R.K.,Agrawal, A. 2020. Anti-inflammatory role of curcumin in Lipopolysaccharide treated A549 cells at global proteome level and on mycobacterial infection. bioRxiv 721100; doi: https://doi.org/10.1101/721100
Ghosh, N., Choudhury, P., Kaushik, S.R., Arya, R., Nanda, R., Bhattacharyya, P., Roychowdhury, S., Banerjee, R., Chaudhury, K. 2020. Metabolomic fingerprinting and systemic inflammatory profiling of asthma COPD overlap (ACO). Respiratory Res 21, 126.
Gupta, N.J., Nanda, R.K., Das, S., Das, M.K., Arya, R. 2020. Night Migratory Songbirds Exhibit Metabolic Ability to Support High Aerobic Capacity during Migration. ACS Omega, 5, 43, pp. 28088–28095. https://doi.org/10.1021/acsomega.0c03691
Lingwan M, Shagun S, Pant Y, Kumari B, Nanda R, Masakapalli SK. (2020) Antiviral phytochemicals identified in Rhododendron arboreum petals exhibited strong binding to SARS-CoV-2 MPro and Human ACE2 receptor. Preprints. 2020080530, 2020. preprints.org
Kumar, S., Sharma, C., Kaushik, S.R., Kulshreshtha, A., Chaturvedi, S., Nanda, R.K., Bhaskar, A., Chattopadhyay, D., Das, G., Dwivedi, V.P. 2019. The phytochemical bergenin as an adjunct immunotherapy for tuberculosis in mice. Journal Biological Chemistry, 294(21), pp. 8555-8563
Bishwal, S.C., Das, M.K., Badireddy, V.K., Dabral, D., Das, A., Mahapatra, A.R., Sahu, S., Malakar, D., Singh, I.I., Mazumdar, H., Patgiri, S.J., Deka, T., Kapfo, W., Liegise, K., Kupa, R.U., Debnath, S., Bhowmik, R., Debnath, R., Behera, R.K., Pillai, M.G., Deuri, P., Nath, R., Khalo, K.P., Sing, W.A., Pandit, B., Das, A., Bhattacharya, S., Behera, D., Saikia, L., Khamo, V., Nanda, R.K.* 2019. Sputum proteomics reveals a shift in vitamin d-binding protein and antimicrobial protein axis in tuberculosis patients. Scientific Reports, 9(1):1036
Rahman, M.R., Islam, T., Turanli, B., Zaman, T., Faruquee, H.M., Rahman, M.M., Mollah, M.N.H., Nanda, R.K., Arga, K.Y., Gov, E., Moni, M.A. 2019. Network-based approach to identify molecular signatures and therapeutic agents in Alzheimer’s disease. Computational Biology and Chemistry, 78, pp. 431-439
Tousif, S., Singh, D.K., Mukherjee, S., Ahmad, S., Arya, R., Nanda, R., Ranganathan, A., Bhattacharyya, M., Van Kaer, L., Kar, S.K., Das, G. 2017. Nanoparticle-formulated curcumin prevents posttherapeutic disease reactivation and reinfection with Mycobacterium tuberculosis following isoniazid therapy. Frontiers in Immunology, 30, 739
Pradhan, S.N., Das, A., Meena, R., Nanda, R.K. Rajamani, P. 2016. Biofluid metabotyping of occupationally exposed subjects to air pollution demonstrates high oxidative stress and deregulated amino acid metabolism. Scientific Reports, 6:35972
Das, M.K., Arya, R., Debnath, S., Debnath, R., Lodh, A., Bishwal, S.C., Das, A., Nanda, R.K. 2016. Global urine metabolomics in patients treated with first-line tuberculosis drugs and identification of a novel metabolite of ethambutol. Antimicrobial Agents and Chemotherapy, 60, pp. 2257-64
Das, M.K., Bishwal, S.C., Das, A., Dabral, D., Badireddy, V.K., Pandit, B., Varghese, G.M., Nanda RK. 2015. Deregulated tyrosine-phenylalanine metabolism in pulmonary tuberculosis patients. J Proteome Res. 14: 1947-1956. PubMed link
Das, M.K., Bishwal, S.C., Das, A., Dabral, D., Varshney, A., Badireddy, V.K., Nanda, R. 2014. Investigation of Gender-Specific Exhaled Breath Volatome in Humans by GCxGC-TOF-MS. Anal Chem 86: 1229-1237. PubMed link
Sethi, S., Nanda, R., Chakraborty T. 2013. Clinical application of Volatile Organic Compounds as Potential Biomarkers for Infections. Clin Microbiol Rev 26: 462-475. PubMed link
Subramaniam, S., Thakur, R.K., Yadav, V.K., Nanda, R., Chowdhury, S., Agrawal, A. 2013. Lung cancer biomarkers: State of the art. Journal of Carcinogenesis. 12: 3. PubMed link
Banday, K.M., Pasikanti, K.K., Chan, E.C.Y., Singla, R., Rao, K.V.S., Chauhan, V.S., Nanda, R.K. 2011. Use of urine volatile organic compounds to discriminate tuberculosis patients from healthy subjects. Anal Chem. 83: 5526- 5534. PubMed link