Group leader, Translational Health
Aruna Asaf Ali Marg
110 067 New Delhi, INDIA
Tel: +91-11-26741358 ext 426
Indian Institute of Technology Kharagpur, India, PhD, 2008
Sambalpur University, School of Life Sciences, Sambalpur, India, MSc, 2001
Since 2009, Staff Research Scientist of the Immunology Group, International Centre for Genetic Engineering and Biotechnology (ICGEB), New Delhi, India.
2007-2009, Research Scientist, ICGEB New Delhi.
Our long-term interest is to develop an alternate, preferably a noninvasive method of disease diagnosis that could be useful at a point of care facility with limited resource conditions. The immediate focus is to profile and identify important features (e.g. proteins, volatile organic compounds or miRNA) from different biofluids of humans, collected from collaborative clinical sites representing diverse geographical locations. We are employing robust multidimensional gas/liquid chromatography and mass spectrometry techniques to identify and quantify micro/macro molecular constituents of biofluids of tuberculosis active and suspect study groups. Comparative proteomics and metabolomics tool with system biology approaches are employed to identify important molecular constituents and their biological significance to explain disease specific perturbed conditions. Our phase-I/II breath based biomarker discovery work shows promising results and we will hopefully translate these findings to develop a POC test in the format of eNOSE in coming years.
Das, M.K., Bishwal, S.C., Das, A., Dabral, D., Badireddy, V.K., Pandit, B., Varghese, G.M., Nanda RK. 2015. Deregulated tyrosine-phenylalanine metabolism in pulmonary tuberculosis patients. J Proteome Res. 14: 1947-1956. PubMed link
Das, M.K., Bishwal, S.C., Das, A., Dabral, D., Varshney, A., Badireddy, V.K., Nanda, R. 2014. Investigation of Gender-Specific Exhaled Breath Volatome in Humans by GCxGC-TOF-MS. Anal Chem 86: 1229-1237. PubMed link
Sethi, S., Nanda, R., Chakraborty T. 2013. Clinical application of Volatile Organic Compounds as Potential Biomarkers for Infections. Clin Microbiol Rev 26: 462-475. PubMed link
Subramaniam, S., Thakur, R.K., Yadav, V.K., Nanda, R., Chowdhury, S., Agrawal, A. 2013. Lung cancer biomarkers: State of the art. Journal of Carcinogenesis. 12: 3. PubMed link
Banday, K.M., Pasikanti, K.K., Chan, E.C.Y., Singla, R., Rao, K.V.S., Chauhan, V.S., Nanda, R.K. 2011. Use of urine volatile organic compounds to discriminate tuberculosis patients from healthy subjects. Anal Chem. 83: 5526- 5534. PubMed link