Group leader, Translational Health
ICGEB Laboratories
ICGEB Campus
Aruna Asaf Ali Marg
110 067 New Delhi, INDIA
E-mail: [email protected]
Tel: +91-11-26741358 ext 426
Education
Indian Institute of Technology Kharagpur, India, PhD, 2008
Sambalpur University, School of Life Sciences, Sambalpur, India, MSc, 2001
Career History
Since 2015, Group Leader, Translational Health Group
2009-2015, Staff Research Scientist of the Immunology Group, International Centre for Genetic Engineering and Biotechnology (ICGEB), New Delhi, India.
2007-2009, Research Scientist, ICGEB New Delhi.
Scientific Activity
Our long-term interest is to develop an alternate, preferably a noninvasive method of disease diagnosis that could be useful at a point of care facility with limited resource conditions. The immediate focus is to profile and identify important features (e.g. proteins, volatile organic compounds or miRNA) from different biofluids of humans, collected from collaborative clinical sites representing diverse geographical locations. We are employing robust multidimensional gas/liquid chromatography and mass spectrometry techniques to identify and quantify micro/macro molecular constituents of biofluids of tuberculosis active and suspect study groups. Comparative proteomics and metabolomics tool with system biology approaches are employed to identify important molecular constituents and their biological significance to explain disease specific perturbed conditions. Our phase-I/II breath based biomarker discovery work shows promising results and we will hopefully translate these findings to develop a POC test in the format of eNOSE in coming years.
Selected Publications
Akram, S., Thakur, J., Shree, M., Masakapalli, S.K., Nanda, R.K. 2020. Kinetic isotope tracing of glycerol and de novo proteogenic amino acids in Human Lung Carcinoma cells using [13C6]glucose. bioRxiv 2020.10.28.358432; doi: https://doi.org/10.1101/2020.10.28.358432.
Singh, K.V., Prakash, C., Nirala, J.P., Nanda, R.K., Rajamani, P.* 2020. Acute radiofrequency electromagnetic radiation exposures cause neuronal DNA damage and impair neurogenesis in the young adolescent rat brain. bioRxiv 2020.11.07.370627
Sahu, D., Biswal, S.C., Malik, MdZ., Sahu, S., Kaushik, S.R., Sharma, S., Saini, E., Arya, R., Rastogi, A., Sharma, S., Sen, S., Singh, R.K.B., Nanda, R.K., Panda, A.K. 2020. Troxerutin acts on complement mediated inflammation to ameliorate arthritic symptoms in rats. bioRxiv 2020.08.18.253427; doi: https://doi.org/10.1101/2020.08.18.253427
Singh, S., Arya, R., Bargaje, R.R., Das, M.K., Akram, S., Faruquee, HMd., Behera, R.K., Nanda, R.K.,Agrawal, A. 2020. Anti-inflammatory role of curcumin in Lipopolysaccharide treated A549 cells at global proteome level and on mycobacterial infection. bioRxiv 721100; doi: https://doi.org/10.1101/721100
Ghosh, N., Choudhury, P., Kaushik, S.R., Arya, R., Nanda, R., Bhattacharyya, P., Roychowdhury, S., Banerjee, R., Chaudhury, K. 2020. Metabolomic fingerprinting and systemic inflammatory profiling of asthma COPD overlap (ACO). Respiratory Res 21, 126.
Gupta, N.J., Nanda, R.K., Das, S., Das, M.K., Arya, R. 2020. Night Migratory Songbirds Exhibit Metabolic Ability to Support High Aerobic Capacity during Migration. ACS Omega, 5, 43, pp. 28088–28095. https://doi.org/10.1021/acsomega.0c03691
Lingwan M, Shagun S, Pant Y, Kumari B, Nanda R, Masakapalli SK. (2020) Antiviral phytochemicals identified in Rhododendron arboreum petals exhibited strong binding to SARS-CoV-2 MPro and Human ACE2 receptor. Preprints. 2020080530, 2020. preprints.org
Kumar, S., Sharma, C., Kaushik, S.R., Kulshreshtha, A., Chaturvedi, S., Nanda, R.K., Bhaskar, A., Chattopadhyay, D., Das, G., Dwivedi, V.P. 2019. The phytochemical bergenin as an adjunct immunotherapy for tuberculosis in mice. Journal Biological Chemistry, 294(21), pp. 8555-8563
Bishwal, S.C., Das, M.K., Badireddy, V.K., Dabral, D., Das, A., Mahapatra, A.R., Sahu, S., Malakar, D., Singh, I.I., Mazumdar, H., Patgiri, S.J., Deka, T., Kapfo, W., Liegise, K., Kupa, R.U., Debnath, S., Bhowmik, R., Debnath, R., Behera, R.K., Pillai, M.G., Deuri, P., Nath, R., Khalo, K.P., Sing, W.A., Pandit, B., Das, A., Bhattacharya, S., Behera, D., Saikia, L., Khamo, V., Nanda, R.K.* 2019. Sputum proteomics reveals a shift in vitamin d-binding protein and antimicrobial protein axis in tuberculosis patients. Scientific Reports, 9(1):1036
Rahman, M.R., Islam, T., Turanli, B., Zaman, T., Faruquee, H.M., Rahman, M.M., Mollah, M.N.H., Nanda, R.K., Arga, K.Y., Gov, E., Moni, M.A. 2019. Network-based approach to identify molecular signatures and therapeutic agents in Alzheimer’s disease. Computational Biology and Chemistry, 78, pp. 431-439
Tousif, S., Singh, D.K., Mukherjee, S., Ahmad, S., Arya, R., Nanda, R., Ranganathan, A., Bhattacharyya, M., Van Kaer, L., Kar, S.K., Das, G. 2017. Nanoparticle-formulated curcumin prevents posttherapeutic disease reactivation and reinfection with Mycobacterium tuberculosis following isoniazid therapy. Frontiers in Immunology, 30, 739
Pradhan, S.N., Das, A., Meena, R., Nanda, R.K. Rajamani, P. 2016. Biofluid metabotyping of occupationally exposed subjects to air pollution demonstrates high oxidative stress and deregulated amino acid metabolism. Scientific Reports, 6:35972
Das, M.K., Arya, R., Debnath, S., Debnath, R., Lodh, A., Bishwal, S.C., Das, A., Nanda, R.K. 2016. Global urine metabolomics in patients treated with first-line tuberculosis drugs and identification of a novel metabolite of ethambutol. Antimicrobial Agents and Chemotherapy, 60, pp. 2257-64
Das, M.K., Bishwal, S.C., Das, A., Dabral, D., Badireddy, V.K., Pandit, B., Varghese, G.M., Nanda RK. 2015. Deregulated tyrosine-phenylalanine metabolism in pulmonary tuberculosis patients. J Proteome Res. 14: 1947-1956. PubMed link
Das, M.K., Bishwal, S.C., Das, A., Dabral, D., Varshney, A., Badireddy, V.K., Nanda, R. 2014. Investigation of Gender-Specific Exhaled Breath Volatome in Humans by GCxGC-TOF-MS. Anal Chem 86: 1229-1237. PubMed link
Sethi, S., Nanda, R., Chakraborty T. 2013. Clinical application of Volatile Organic Compounds as Potential Biomarkers for Infections. Clin Microbiol Rev 26: 462-475. PubMed link
Subramaniam, S., Thakur, R.K., Yadav, V.K., Nanda, R., Chowdhury, S., Agrawal, A. 2013. Lung cancer biomarkers: State of the art. Journal of Carcinogenesis. 12: 3. PubMed link
Banday, K.M., Pasikanti, K.K., Chan, E.C.Y., Singla, R., Rao, K.V.S., Chauhan, V.S., Nanda, R.K. 2011. Use of urine volatile organic compounds to discriminate tuberculosis patients from healthy subjects. Anal Chem. 83: 5526- 5534. PubMed link