Rafael RADI

Monday, 12 September 2022 | 12.00 noon – ICGEB Trieste, ITALY

Professor and Chair of Biochemistry, Director, Centro de Investigaciones Biomédicas (CEINBIO) Departamento de Bioquímica, Facultad de Medicina, Universidad de la República, Montevideo, URUGUAY

Oxygen Radicals, Nitric Oxide and Peroxynitrite: Redox Biochemistry in Human Disease

(Host: L. Banks)

In the seminar, the following topics will be analyzed: 1) main sources of oxygen radicals and nitric oxide and their interplay leading to the oxidizing and pathogenic mediator peroxynitrite in human biology; 2) relevant oxidative modifications in key biomolecules in pathology and aging, including protein tyrosine nitration; 3) intertwined roles of mitochondrial dysfunction and oxidative stress; 4) endogenous mechanisms to cope with excess levels of reactive species; and 5) emerging applications of redox-based therapeutics for the prevention and treatment of human diseases. Overall, the seminar is aimed to provide updated concepts on how free radical and redox metabolism influences human health and disease processes.