Key Laboratory of “Cell Differentiation and Apoptosis” of Chinese Ministry of Education, Department of Pathophysiology Shanghai Jiaotong University School of Medicine, Shanghai, CHINA

Friday, 14 October 2022 | 6:00 pm – Shanghai time, CHINA

Biochemical Dissection and Functional Analysis of Autophagy

Host: N. Yang

Professor Zhong graduated from Peking Union Medical College in 1995 and received PhD in molecular medicine from University of Texas Health Science Center at San Antonio in 2000. He then worked as assistant Professor at University of California at Berkeley, and tenured associate professor at University of Texas Southwestern Medical Center. He became Professor and Chair of Department of Pathophysiology, Shanghai Jiaotong University School of Medicine in 2018.

Autophagy is a highly regulated cellular degradation system that engulfs cytosol, organelles, protein aggregates and invading microorganisms into a double- membrane vesicle termed the autophagosome, then delivers cargo to endolysosomes for degradation. Autophagy dysfunction has been implicated in a broad spectrum of human diseases, including cancers, neurodegeneration, infectious diseases, metabolic diseases and aging. Professor Zhong’s lab focuses on the biochemical mechanisms of autophagosome biogenesis, substrate recruitments and autophagosome fusion with lysosomes. They have identified and characterized novel protein factors essential for autophagy initiation, cargo recruitment and autophagosome-lysosome fusion.


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