PfLPL3: A critical lysophospholipase at host-parasite interface - published in Cell Reports, Vol. 42, Issue 4, 2023

Publication Highlights

ICGEB’s Principal Investigators author a large number of papers in high-impact scientific journals each year. We regularly cite recent publications, and this month also consider the value and recognition obtained through citation metrics by our researchers.

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Published in Cell Reports, researchers from the Mohmmed Group observed that Plasmodium falciparum lysophospholipase PfLPL3 has a key role in parasite propagation during asexual blood stages which may serve as a pertinent chemical tool to study parasite lipid synthesis.

Link to article: A Plasmodium falciparum lysophospholipase regulateshost fatty acid flux via parasite lipid storage to enablecontrolled asexual schizogony.

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The Cardiovascular Biology Group led by Dr. Serena Zacchigna recently published an article in the Journal of Experimental & Clinical Cancer Research presenting a first in vivo screening, precisely designed to identify proteins able to interfere with cancer cell invasiveness.

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The Bacteriology Group led by Dr. Vittorio Venturi was recently involved in publishing a Comments & Opinion article in Nature Plants on the importance of the adoption of agricultural biotechnology in developing countries for achieving by 2030 the UN Sustainable Development Goal of Zero Hunger.

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Published in Nature Cardiovascular Research, researchers from the Giacca Group have collaborated to lay the foundation for the development of a gene therapy for the genetic heart disease arryhthmogenic cardiomyopathy (ACM).

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The ICGEB Virology – Emerging Viruses Group, in collaboration with the Desmond Tutu HIV Foundation,  has been involved in clinical studies to assess long-term effects of SARS-CoV-2 infection on reactivation of oncogenic viruses such as Kaposi’s Sarcoma Herpesvirus (KSHV) in HIV-coinfected patients. A recent paper has been accepted for publication in “The Lancet – EbioMedicine” where they report on the impact of exposure to multiple SARS-CoV-2 infection waves on KSHV reactivation in immunocompromised unvaccinated non-hospitalised patients. They speculate that the cumulative SARS-CoV-2-induced damage to immune functions may have downstream consequences for immunodeficiency-associated and/or virus-associated malignancies in the post-pandemic era which needs to be closely monitored in vulnerable populations with high prevalence of oncogenic viruses:.

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In October 2023, Elsevier published an update of science-wide author databases of standardised citation indicators. This is the 6th edition, citing the World’s Top 2% of Scientists.

Three scientists from ICGEB have been inserted in the list for career-long data in their specific research field. These are Lawrence Banks, ICGEB Director-General and Group Leader of the Tumour Virology lab, Emanuele Buratti, Group Leader of the Molecular Pathology lab, and Vittorio Venturi, ICGEB Scientific Coordinator and Group Leader of the Bacteriology lab.

In addition, based on single year impact data for 2022, two additional researchers from ICGEB have been included: Sneh Lata Singla-Pareek, Group Leader of the Plant Stress Biology lab, and Serena Zacchigna, Group Leader of the Cardiovascular Biology lab.

Congratulations to these scientists for this international recognition!

These findings are reported from a publicly available database of top-cited scientists that provides standardised information. This work uses Scopus data provided by Elsevier through the ICSR Lab.

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ICGEB offers an editorial service for scientists and institutes from its Member States, to support and encourage the successful publication of scientific papers.