Pier Paolo PETRONE

Friday, 8 October 2021 | 12:00 noon – ICGEB Trieste, ITALY

Laboratory of Human Osteobiology and Forensic Anthropology, Departmental Section of Legal Medicine, Histology & Anatomy, Department of Advanced Biomedical Sciences, University Federico II of Naples, ITALY

Volcanoes, Bones and Heat: New Forensic and Bioarchaeological Evidence from the 79 AD Herculaneum Victims

(Host: E. Buratti)

Emerging evidence show that metabolites’ concentration impacts the epigenome: many metabolites are substrates of, or cofactors for several chromatin remodeling enzymes. For example, the central Krebs’ cycle metabolite acetyl-CoA is also the donor substrate for acetylation reactions and its availability dictates global levels of histone acetylation. My work shows that acetyl-CoA availability fluctuates in mammalian cells and organs, in response to diet, nutrient availability, oncogenic signaling among other inputs. This ultimately influences cell fate decisions and has consequences for tumorigenesis.