Emeritus Senior Scientist
International Centre for Genetic Engineering and Biotechnology
Padriciano 99
34149 Trieste, Italy
E-mail: [email protected]
Tel: +39-040-3757314/310/311
Education
Faculty of Sciences, University of Buenos Aires, Argentina, Bachelor in Chemical Sciences, 1975
Faculty of Sciences, University of Buenos Aires, Argentina, PhD in Biological Chemistry, 1979
Career History
Since 2020, Emeritus Senior Scientist, ICGEB
1997-2019, Co-ordinator of the PhD Course in Molecular Genetics of the ICGEB, Trieste, Italy.
1990-2019, Senior Scientist and Group Leader of the Molecular Immunology Group of the ICGEB, Trieste, Italy.
1985-1993, Assistant Professor, Instituto de Investigaciones Bioquímicas, Faculty of Sciences, University of Buenos Aires, Argentina.
1985-1989, Member of the Executive Committee of the National Program of Biotechnology, Ministry of Science and Technology, Buenos Aires, Argentina.
1983-1992, Scientific Career Member of the National Research Council (CONICET), Argentina.
1983-1990, Head of the Laboratory of Molecular Immunology and Virology, “Instituto Luis F. Leloir de Investigaciones Bioquimicas”, “Fundación Campomar”, Buenos Aires, Argentina.
1981-1983, Staff Research Scientist, MRC Laboratory of Molecular Biology, Division of Protein and Nucleic Acid Chemistry, Cambridge, England.
1979-1981, Postdoctoral research fellow, MRC Laboratory of Molecular Biology, Division of Protein and Nucleic Acid Chemistry, Cambridge, England.
1974-1979, Pre-doctoral research fellow, Instituto de Investigaciones Bioquimicas, “Fundación Campomar”, and Faculty of Sciences, University of Buenos Aires, Argentina.
Scientific Activity
Research interests focus in two major areas: immunology (a) and virology (b). a includes protein engineering of antibody molecules, structural and functional aspects of IgE and its receptors, DNA based vaccines for tumour immunotherapy and receptors of dendritic cells. b includes the molecular biology of rotavirus replication and the role of non-structural proteins in virus morphogenesis.
Teaching Activity
Since 1998, Lecturer of Biological Sciences, Master in Science Communication, Scuola Internazionale di Studi Superiori Avanzati (ISAS/SISSA), Trieste, Italy.
Selected publications
Pulecio J., Petrovic, J., Prete, F., Chiaruttini, G., Lennon-Dumenil A.M., Desdouets C., Gasman, S., Burrone, O.R., Benvenuti, F. 2010. Cdc42-mediated MTOC polarization in dendritic cells controls targeted delivery of cytokines at the immune synapse. J Exp Med 207, 2719-2732 PubMed link
Arnoldi, F., Burrone, O.R. 2009. Role of viral non-structural proteins in rotavirus replication. Future Virology 4, 185-197
López-Requena, A., Burrone, O.R. 2009. Anti-Idiotypic Antibodies and “Tumor-Only” Antigens: An Update. Open Immun. J. 2, 1-8
Cesco-Gaspere, M., Zentilin, L., Giacca, M., Burrone, O.R. 2008. Boosting anti-idiotype immune response with recombinant AAV enhances tumour protection induced by Gene Gun vaccination. Sc. J. Imm. 68, 58-66 PubMed link
Predonzani, A., Arnoldi, F., López-Requena, A., Burrone, O.R. 2008. In vivo site-specific biotinylation of proteins within the secretory pathway using a single vector system. BMC Biotechnology 8, 41 PubMed link
Pulecio, J., Tagliani, E., Scholer, A., Prete F., Fetler, L., Burrone, O.R., Benvenuti, F. 2008. Expression of Wiskott-Aldrich syndrome protein in dendritic cells regulates synapse formation and activation of naive CD8+ T cells. J.Immunol, 181, 1135-1142
Tagliani E., Guermonprez P., Sepúlveda J., Lopez Bravo M., Ardavin C., Amigorena S., Benvenuti, F., Burrone O.R. 2008. Selection of an antibody library identifies a pathway to induce immunity by targeting CD36 on steady state CD8a+ dendritic cells. J. Immunol. 180, 3201-3209 Pubmed link
Campagna , M., Budini, M., Arnoldi, F., Desselberger, U., Allende, J.E., Burrone, O.R. 2007. Impaired hyperphosphorylation of rotavirus NSP5 in cells depleted of casein kinase 1a is associated with the formation of viroplasms with altered morphology and a moderate decrease in virus replication. J. Gen. Virol., 88, 2800-10 PubMed link
Arnoldi, F., Campagna, M., Eichwald, C., Desselberger, U., Burrone, O.R. 2007. The interaction of the rotavirus polymerase VP1 with the non-structural protein NSP5 is stronger than with NSP2. J. Virol. 81, 2128-2137
Bestagno, M., Sola, I., Dallegno, E., Sabella, P., Poggianella, M., Plana-Durán, J., Enjuanes, L., Burrone, O.R. 2007. Recombinant dimeric small immune proteins (SIPs) efficiently neutralise Transmissible Gastroenteritis Virus infectivity in vitro and confer passive immunity in vivo. J. Gen. Virol. 88, 187-195