INDUSTRIAL BIOTECHNOLOGY / Biofuels and Industrial Biotechnology
Integrated “Omics”, Metabolic Engineering, Algal Biotechnology, Biofuels
Description of Research
Microalgae, a potential source for next-generation renewable biofuels
Microalgae hold promising source of renewable energy to replace diminishing oil reserves as a source of lipids for biofuels. Algal Oils are rich in the triacylglycerols (TAGs) that serve as material for conversion to biofuels. Studies on the biosynthetic pathways and rate limiting steps of triacylglycerol formation in microalgae are still infancy. My research aims to study the overall TAG biosynthesis pathway, oil mobilization and role of beta-oxidation genes in TAG catabolism and also RNA-mediated silencing altering the lipid content with increase in overall lipid production or shift the balance of lipid production. Understanding these biosynthetic pathways and the adaptation of systems-based approaches to metabolic engineering of microalgae may be a critical step towards making algae-derived biofuels economically competitive.
Exploring the Microalgal Systems through Integrated “Omics” Research
Decreasing fossil fuels and its impact on global warming led to an increasing demand for its replacement by sustainable renewable biofuels. Microalgae may offer a potential feedstock for renewable biofuels capable of converting atmospheric CO2 to substantial biomass and valuable biofuels, which is of great importance for the food and energy industries. Integrated “Omics” Research is a powerful tool in understanding the behavior of biological systems as a whole, where the metabolic pathways are often highly regulated and connected with a number of both feedforward and feedback mechanisms that can act positively and/or negatively ultimately affecting the systems output. Understanding the entire system through Integrated “Omics” Research will lead to identify relevant enzyme-encoding genes, and reconstruct the metabolic pathways involved in the biosynthesis and degradation of precursor molecules that may have potential for biofuel production, aiming towards the vision of tomorrow’s bioenergy needs.
Asha, A.N., Kashif, M.S., Mundree, S., Jutur P.P. Triggers and Cues in the Activation of Algal Metabolic Pathways. Algal Green Chemistry: Recent Progress in Biotechnology. Ed. R.P. Rastogi, D. Madamwar, A. Pandey. Elsevier Science, 2016
Asha, A.N., Kashif, M.S., Jutur, P.P. De novo Transcriptomics in Marine Microalgae: An Advanced Genetic Engineering Approach for Next-Generation Renewable Biofuels. Marine OMICS: Principles and Applications. Ed. S.K. Kim. CRC Press, July 2016
Asha, A.N., Kashif, M.S., Jutur, P.P. Genetic Engineering of Microalgae for Production of Value-Added Ingredients. Handbook of Marine Microalgae: Biotechnology Advances. Ed. S.K. Kim, Elsevier Science, 2015 pp. 371-381
Jutur, P.P., Asha, A.N. Genetic Engineering of Marine Microalgae to Optimize Bioenergy Production. Handbook of Marine Microalgae: Biotechnology Advances. Ed. S.K. Kim, Elsevier Science, 2015 pp. 405-414
Jutur, P.P., Asha, A.N. Marine Microalgae: Exploring the Systems through an Omics Approach for Biofuel Production. Marine Bioenergy: Trends and Developments. Ed. S.K. Kim, C.G. Lee. CRC Press, 2015 pp. 149-162
Kashif, M.S., Jutur, P.P. Manipulation of Essential Metabolic Pathway Genes for Enhanced Production of Microalgal Renewables: Insights from Phylogenomics and Future Challenges. Algal Green Chemistry: Recent Progress in Biotechnology. Ed. R.P. Rastogi, D. Madamwar, A. Pandey. Elsevier Science, 2016