Group Leader, Transcriptional Regulation
International Centre for Genetic Engineering and Biotechnology
Aruna Asaf Ali Marg
110 067 New Delhi, India
Tel: +91-11-26741358/ 26741361/ 26742357/ 26742360 ext. 163
Goa University, Goa, India, MSc, 1998
Tata Institute of Fundamental Research, Mumbai, India, PhD, 2003
2015– Group Leader, Transcriptional Regulation, International Centre for Genetic Engineering and Biotechnology (ICGEB), New Delhi, India
2008-2015, Staff Research Scientist, Structural and Computational Biology Group, ICGEB New Delhi, India
2004-2008, Postdoctoral Fellow, Group Wüthrich, Institute of Molecular Biology and Biophysics, ETH Zurich, Switzerland
2003-2004, Visiting Fellow, Department of Chemical Sciences, Tata Insitute of Fundamental Research, Mumbai, India
1998-2003, Research Scholar, Department of Chemical Sciences, Tata Institute of Fundamental Research, Mumbai, India
His group uses an interdisciplinary approach encompassing a wide array of biophysical, biochemical and molecular biology techniques for understanding the structure and function of macromolecules with special thrust on molecular mechanism of Protein-RNA interactions. Solution-state NMR spectroscopy and X-ray crystallography are synergistically used in his group for determination of atomic resolution structures of protein-RNA complexes that provide a wealth of information pertaining to the binding interfaces, recognition mechanisms, and the forces that stabilize these complexes. Current research focuses on RNA binding proteins that involved in post-transcription regulation of mRNA to decipher a possible general code of RNA recognition. He also uses NMR spectroscopy for metabolic profiling of bio-fluids to understand dysregulation during disease condition and help in identification of biomarkers. Research activity is funded through grants from various public and private bodies, including the Department of Biotechnology and Department of Science and Technology, Government of India.
He is member of the editorial board of Nature Scientific Reports and reviews scientific manuscripts for international journals in the fields of structural biology and grant applications from various granting bodies in India. He presents regularly his research activity at international meetings and seminars.
Member, JNU-ICGEB Academic Committee.
Course coordinator for PhD course in Physical and Computational Biology and teaching faculty at ICGEB, New Delhi for other courses and ICGEB workshops.
In charge of the PhD examination and admissions committee at ICGEB, New Delhi, India.
Kashyap, M., Ganguly, A.K., Bhavesh, N.S. 2015. Structural delineation of stem-loop RNA binding by human TAF15 protein Sci Rep. 5, 17298 (1-14). DOI: 10.1038/srep17298 PubMed link
Anand, A., Verma, P., Singh, A.K., Kaushik, S., Pandey, R., Shi, C., Kaur, H., Chawla, M., Elechalawar, C.K., Kumar, D., Yang, Y., Bhavesh, N.S., Banerjee, R., Dash, D., Singh, A., Natarajan, V.T., Ojha, A.K., Aldrich, C.C., Gokhale, R.S. 2015. Polyketide quinones are novel intermediate electron carriers during mycobacterial respiration in oxygen-deficient niches Mol. Cell. 60, 637-650, DOI: 10.1016/j.molcel.2015.10.016 PubMed link
Ganguly, A.K., Ranjan, P., Kumar, A., Bhavesh, N.S. 2015. Dynamic association of PfEMP1 and KAHRP in knobs mediates cytoadherence during Plasmodium invasion Sci. Rep. 5, 8617 (1-9). DOI:10.1038/srep08617 PubMed link
Munshi, S.U., Rewari, B.B., Bhavesh, N.S., Jameel, S. 2013. Nuclear magnetic resonance based profiling of biofluids reveals metabolic dysregulation in HIV-infected persons and those on anti-retroviral therapy PLoS One 8, e64298(1-9) DOI:10.1371/journal.pone.0064298 PubMed link
Trivedi, D.K., Bhatt, H., Pal, R.K., Tuteja, R., Garg, B., Johri, A.K., Bhavesh, N.S., Tuteja, N. 2013. Structure of RNA-interacting Cyclophilin A-like protein from Piriformospora indica that provides salinity-stress tolerance in plants Sci. Rep. 3, 3001(1-9) DOI:10.1038/srep03001 PubMed link
Kashyap M, Sharma A andBhavesh NS (2013) Purification, crystallization and preliminary crystallographic studies of C-terminal RNA recognition motif (RRM-3) of human ELAV type RNA binding protein-3 (ETR-3) Acta Crystallogr. F69,1107-1109. DOI:10.1107/S1744309113023439
Kamthan, M., Kamthan, A., Ruhela, D., Maiti, P., Bhavesh, N.S., Datta, A. 2013. Upregulation of galactose metabolic pathway by N-acetylglucosamine induced endogenous synthesis of galactose in Candida albicans. Fungal Genet Biol. 54, 15-24 DOI:10.1016/j.fgb.2013.02.006 PubMed link
Honnappa S, Montenegro-Gouveia S, Weisbrich A, Damberger FF, Bhavesh NS, Jawhari H, Grigoriev I, van Rijssel FJA, Buey RM, Lawera A, Jelesarov I, Winkler FK, Wüthrich K, Akhmanova A and Steinmetz MO (2009) A universal EB1-binding motif acts as a microtubule tip localization signal Cell 138, 366-376. DOI:10.1016/j.cell.2009.04.065