Neel Sarovar Bhavesh

Group Leader, Transcriptional Regulation
International Centre for Genetic Engineering and Biotechnology
Aruna Asaf Ali Marg
110 067 New Delhi, India
Tel: +91-11-26741358/ 26741361/ 26742357/ 26742360 ext. 163

Education

Goa University, Goa, India, MSc, 1998
Tata Institute of Fundamental Research (TIFR), Mumbai, India, PhD, 2003

Career History

2015– Group Leader, Transcriptional Regulation, International Centre for Genetic Engineering and Biotechnology (ICGEB), New Delhi, India
2008-2015, Staff Research Scientist, Structural and Computational Biology Group, ICGEB New Delhi, India
2004-2008, Postdoctoral Fellow, Group Wüthrich, Institute of Molecular Biology and Biophysics, ETH Zürich, Switzerland
2003-2004, Visiting Fellow, Department of Chemical Sciences, Tata Insitute of Fundamental Research, Mumbai, India
1998-2003, Research Scholar, Department of Chemical Sciences, Tata Institute of Fundamental Research, Mumbai, India

Scientific Activity

His group uses an interdisciplinary approach encompassing a wide array of biophysical, biochemical and molecular biology techniques for understanding the structure and function of macromolecules with special thrust on molecular mechanism of Protein-RNA interactions. Solution-state NMR spectroscopy and X-ray crystallography are synergistically used in his group for determination of atomic resolution structures of protein-RNA complexes that provide a wealth of information pertaining to the binding interfaces, recognition mechanisms, and the forces that stabilize these complexes. Current research focuses on RNA binding proteins that involved in post-transcription regulation of mRNA to decipher a possible general code of RNA recognition. He also uses NMR spectroscopy for metabolic profiling of bio-fluids to understand dysregulation during disease condition and help in identification of biomarkers. Research activity is funded through grants from various public and private bodies, including the Department of Biotechnology and Department of Science and Technology, Government of India.

He is member of the editorial board of Nature Scientific Reports and reviews scientific manuscripts for international journals in the fields of structural biology and grant applications from various granting bodies in India. He presents regularly his research activity at international meetings and seminars.

Teaching Activity

Member, Academic Council, Jawaharlal Nehru University (JNU), New Delhi
Member, JNU-ICGEB Academic Committee.
Member, Research Advisory Committee, Patna University, Patna.
Course coordinator for PhD course in Physical and Computational Biology and teaching faculty at ICGEB, New Delhi for other courses and ICGEB workshops.
In charge of the PhD examination and admissions committee at ICGEB, New Delhi, India.

Selected publications

For complete list of publications click

Ganguly, A.K., Verma, G., Bhavesh, N.S. 2019. The N-terminal RNA recognition motif of PfSR1 confers semi-specificity for pyrimidines during RNA recognition J. Mol. Biol. 431, 498-510. DOI: 10.1016/j.jmb.2018.11.020 PubMed link

Kushwaha, G. S., Bange, G., Bhavesh, N.S. 2019. Interaction studies on bacterial stringent response protein RelA with uncharged tRNA provide evidence for its prerequisite complex for ribosome binding Curr. Genet. . DOI: 10.1007/s00294-019-00966-y PubMed link

Kashyap, M., Ganguly, A.K., Bhavesh, N.S. 2015. Structural delineation of stem-loop RNA binding by human TAF15 protein Sci Rep. 5, 17298 (1-14). DOI: 10.1038/srep17298 PubMed link

Ganguly, A.K., Ranjan, P., Kumar, A., Bhavesh, N.S. 2015. Dynamic association of PfEMP1 and KAHRP in knobs mediates cytoadherence during Plasmodium invasion Sci. Rep. 5, 8617 (1-9). DOI:10.1038/srep08617 PubMed link

Anand, A., Verma, P., Singh, A.K., Kaushik, S., Pandey, R., Shi, C., Kaur, H., Chawla, M., Elechalawar, C.K., Kumar, D., Yang, Y., Bhavesh, N.S., Banerjee, R., Dash, D., Singh, A., Natarajan, V.T., Ojha, A.K., Aldrich, C.C., Gokhale, R.S. 2015. Polyketide quinones are novel intermediate electron carriers during mycobacterial respiration in oxygen-deficient niches Mol. Cell. 60, 637-650, DOI: 10.1016/j.molcel.2015.10.016 PubMed link

Trivedi, D.K., Bhatt, H., Pal, R.K., Tuteja, R., Garg, B., Johri, A.K., Bhavesh, N.S., Tuteja, N. 2013. Structure of RNA-interacting Cyclophilin A-like protein from Piriformospora indica that provides salinity-stress tolerance in plants Sci. Rep. 3, 3001(1-9) DOI:10.1038/srep03001 PubMed link

Honnappa, S., Montenegro-Gouveia, S., Weisbrich, A., Damberger, F. F., Bhavesh, N. S., Jawhari, H., Grigoriev, I., van Rijssel, F. J. A., Buey, R. M., Lawera, A., Jelesarov, I., Winkler, F. K., Wüthrich, K., Akhmanova, A., Steinmetz, M. O. (2009) A universal EB1-binding motif acts as a microtubule tip localization signal Cell 138, 366-376. DOI:10.1016/j.cell.2009.04.065 PubMed link