Naseem A. Gaur

Group Leader,
Yeast Biofuel

International Centre for Genetic Engineering and Biotechnology
ICGEB-DBT Advanced Bioenergy Research
Aruna Asaf Ali Marg
110 067 New Delhi, India
E-mail: naseem@icgeb.res.in
Tel:  +91-11-26741358 ext 452

Education

Jawaharlal Nehru University /Jamia Millia Islamia University New Delhi, Ph.D., 2005
Jamia Millia Islamia University, New Delhi, M.Sc. (Bio-Sciences), 1999
Jamia Millia Islamia University, New Delhi, B.Sc. (Bio-Sciences), 1997

Career History

2015-Present: Group Leader, International Centre for Genetic Engineering and Biotechnology (ICGEB), New Delhi, India
2012- 2015: Research Scientist and Ramanujan Fellow, ICGEB New Delhi
2010-2012: Research Fellow, National Institutes of Health (NIH), Bethesda, Maryland, USA
2007-2010: Postdoctoral Research Fellow, National Institutes of Health (NIH), Bethesda, Maryland, USA
2005- 2007: Postdoctoral Research Fellow, BWH, Harvard University, Boston, MA, USA

Scientific Activity

Current research interest focuses on developing yeast strains for bio-based chemical production including, bio-alcohols and oleochemicals, Xylo-oligosaccharides, Xylitol and recombinant protein expression. He also maintains a strong interest in the field of human fungal pathogenesis and multidrug resistance.

Research activities are funded through grants from various public and private bodies, including the Department of Science and Technology (DST) and Department of Biotechnology (DBT), Ministry of Science and Technology, Government of India.

Naseem Gaur regularly reviews scientific manuscripts for international journals in the fields of biofuels, Gene expression, multidrug resistance and grant applications in the context of biotechnology. Over 20 papers in peer-reviewed international journals and 5 reviews or chapters in published books. He regularly presents his research activity at meetings and seminars worldwide.

Teaching Activity

Tutoring activities in the ICGEB PhD Programme

Since 2016 – Teaching ‘Transcriptional network and yeast synthetic biology’ as part of ‘Synthetic and Systems Biology’ Course
Since 2015 – Teaching ‘Gene expression in yeast’ as part of ‘Research Methodology’ Course

Selected publications

Pandey, A.K., Kumar, M., Kumari, S., Jakeer, S., Naz, S., Chandna, P., Bhatnagara, I., Kumari, P., Yusuf, F., Gaur, N. A. 2019. Evaluation of divergent yeast genera for fermentation associated stresses and identification of a robust sugarcane distillery waste isolate Saccharomyces cerevisiae NGY10 for lignocellulosic ethanol production in SHF and SSF. Biotechnol Biofuels doi: 10.1186/s13068-019-1379-x. eCollection 2019. PMID: 30858877

Khandelwal, N.K., Wasi, M., Nair, R., Gupta, M., Kumar, M., Mondal, A.K., Gaur, N.A., Prasad, R. 2019. Vacuolar sequestration of azoles: A novel strategy of azole antifungal resistance conserved across pathogenic and non-pathogenic yeast.  Antimicrob Agents Chemother. doi: 10.1128/AAC.01347-18. PMID: 30642932

Kumari, S., Kumar, M., Khandelwal, N.K., Kumari, P., Varma, M., Vishwakarma, P., Shahi, G., Sharma, S., Lynn, A.M., Prasad, R., Gaur, N.A. 2018. ABC transportome inventory of human pathogenic yeast Candida glabrata: Phylogenetic and expression analysis. PLoS One 28, 13 e0202993 PMID: 30153284

Nair, R., Khandelwal, N.K., Shariq, M., Redhu, A.K., Gaur, N.A., Shaikh, S., Prasad, R. 2018. Identification of genome-wide binding sites of heat shock factor 1, Hsf1, under basal conditions in the human pathogenic yeast, Candida albicans. AMB Express 8, 116. doi: 10.1186/s13568-018-0647-7. PMID: 30014253

Khandelwal, N.K., Sakar, P., Gaur, N.A., Chattopadhyay, A., Prasad, R. 2018. Phosphotidylserine decarboxylase governs plasma membrane fluidity and impacts drug susceptibilities of Candida albicans cells. Biochem Biophys Acta 2736, 30158-5. doi: 10.1016/j.bbamem.2018.05.016. PMID: 29856993

Khandelwal, N.K., Chauhan, N., Sarkar, P., Esquivel, B.D., Coccetti, P., Singh, A., Coste, A.T., Gupta, M., Sanglard, D., White, T.C., Chauvel, M., d’Enfert, C., Chattopadhyay, A., Gaur, NA., Mondal, A.K., Prasad R. 2018. Azole resistance in a candida albicans mutant lacking the ABC transporter CDR6/ROA1 depends on TOR signalling. J Biol Chem 293, 412-432 doi: 10.1074/jbc.M117.807032. PMID: 29158264

Dubey, R., Jakeer, S., Gaur, N.A. 2016 Screening of natural yeast isolates under the effects of stresses associated with second-generation biofuel production. J Biosci Bioeng 121, 509-516 PubMed link

Dubey, R., Jakeer, S., Gaur, N.A. 2015. Screening of natural yeast isolates under the effects of stresses associated with second-generation biofuel production. J Biosci Bioeng. Oct 16. pii: S1389-1723(15)00337-0. doi: 10.1016/j.jbiosc.2015.09.006

Gaur N.A., Hasek J, Garvey Brickner D, Qiu H, Zhang F, Wong CM, Malcova I, Vasicova P, Brickner JH, Hinnebusch A. 2013. Vps Factors are Required for Efficient Transcription Elongation in Budding Yeast. Genetics. Mar;193(3):829-851

Qiu, H., Hu, C., Gaur, N. A., Hinnebusch, A G. 2012. Pol II CTD kinases Bur1 and Kin28 promote Spt5 CTR-independent recruitment of Paf1 complex. EMBO J. 2012 Aug 15;31(16):3494-3505

Mousley, C. J., Yuan, P., Gaur, N.A., Trettin,  K.D., Nile, A.H., Dewar, B., Deminoff, S., Herman, P.K., Hinnebusch, A.G., Macdonald, J.M., Bankaitis, V.A. 2012. A sterol binding protein integrates endosomal lipid metabolism with TOR signaling and nitrogen sensing. CELL,  Volume 148, Issue 4, 702-715

Chu, J., Loughlin, E.A., Gaur, N.A., Banerjee, S.S., Ding, Y., Monson, C., Ukomadu, C., Sadler, K.C. 2011. UHRF1 phosphorylation by Cyclin A2/CDK2 is required for zebrafish embryogenesis. Mol Biol Cell. Jan;23(1):59-70. Epub 2011 Nov 9

Gaur, N.A., Zhang, F., Hasek, J., Kim, S., Qiu, H., Swanson, M. J., Hinnebusch, A.G. 2008. Disrupting Vesicular Trafficking at the Endosome Attenuates Transcriptional Activation by Gcn4. Mol Cell Biol. 28(22), 6796-6818

Manoharlal, R. Gaur, N. A., Panwar, S. L., Morschhäuser, J., and  Prasad, R. 2008. Transcriptional activation and increased mRNA stability contribute to overexpression of CDR1 in azole-resistant Candida albicans. Antimicrobial Agents Chemother. 52(4), 1481-1492

Pirzadah, T., Garg, S., Singh, J., Vyas, A., Kumar, M., Gaur, N., Bala, M., Rehman, R., Varma, A., Kumar, V., Kumar, M.  2014. Characterization of Actinomycetes and Trichoderma spp. for cellulase production utilizing crude substrates by response surface methodology. SpringerPlus, 3:622

Sadler, K.C. Krahn, K.N., Gaur, N. A., Ukomadu, C. 2007. Liver growth in the embryo and during liver regeneration in Zebrafish requires the cell cycle regulator, uhrf1. PNAS.(USA) 104(5), 1570-1575

Saini, P. Gaur, N.A., Prasad, R., 2006. Chimeras of ABC drug transporter Cdr1p reveal functional indispensability of transmembrane domains and nucleotide binding domains: transmembrane segment 12 is replaceable with similar homologous region of a non-drug transporter Cdr3p. Microbiology. 152(Pt 5), 1559-1573

Gaur, N.A., Manoharlal, R., Saini, P., Prasad, T., Mukhopadhyay, G., Hoefer, M., Morschhäuser, J., Prasad, R. 2005. Expression of the CDR1 efflux pump in Clinical Candida albicans isolates is controlled by a negative regulatory element. BBRC. 332(1), 206-214

Gaur, N.A. Puri, N., Karnani, N., Mukhopadhyay, G., Goswami, S.K., Prasad, R. 2004. Identification of a Negative Regulatory Element Which Regulates Basal Transcription of A Multi-drug Resistance Gene CDR1 of Candida albicans. FEMS Yeast Res. 4(4-5), 389-399