Nadja C. de Souza PINTO

Tuesday, 9 November 2021 | 2:00 pm – Cape Town, SOUTH AFRICA

Associate Professor, Biochemistry Dept., Institute of Chemistry, University of São Paulo, BRAZIL

DNA repair contributes to maintaining mitochondrial function in mammalian cells

(Host: L. Zerbini)

Mitochondria are involved in many essential processes such as energy metabolism, apoptosis and inflammatory response. Thus, maintaining mitochondrial function is central to cellular homeostasis.
Unlike most other organelles, mitochondria contain their own DNA, and mitochondrial DNA stability is required for oxidative phosphorylation (OXPHOS), as the mtDNA encodes 13 polypeptides that are components of 4 of the 5 five OXPHOS complexes. While it was initially proposed that mammalian mitochondria lack DNA repair activities, we now know that they are proficient in at least some types of DNA repair.

Here we will discuss the DNA repair pathways known to operate in mitochondria, and how they may contribute to maintaining mitochondrial function.