Michael P. Myers

Group leader, 
Protein Networks
International Centre for Genetic Engineering and Biotechnology
Padriciano 99
34149 Trieste, Italy

E-mail: myers@icgeb.org 
Tel: +39-040-3757391

Facilities:
Proteomics Facility

Education

Departments of Biology and Physics, DePauw University, Greencastle USA, BA, 1990
Department of Neuroscience, Case Western Reserve University, Cleveland USA, PhD, 1996

Career History

June 2007, Group Leader, Protein Networks, International Center for Genetic Engineering and Biotechnology (ICGEB), Trieste, Italy.
2001-2007, Assistant Professor, Cold Spring Harbor Laboratory, Cold Spring Harbor, USA.
2001, Visiting Scientist, Rockefeller University, New York, USA.
1999-2001, V Foundation Scholar.
1998-2001, Senior Research Fellow, Cold Spring Harbor Laboratory, Cold Spring Harbor, USA.
1996-1998, Postdoctoral Fellow, Cold Spring Harbor Laboratory, Cold Spring Harbor, USA.

Scientific Activity

The goal of my laboratory is to understand how protein complexes regulate cellular behavior.  My laboratory implements new methods for the high throughput analysis of protein interactions (networks) using mass spectrometry.  In particular, we focus on those networks that are (or likely to be) perturbed in a variety of pathological conditions, including tumorigenesis and viral infection.

Teaching Activity

2002-2006, Scientific Reasoning and Logic, Watson School for Biological Sciences, Cold Spring Harbor Laboratory, Cold Spring Harbor, USA.
2006, Lecturer, Protein Purification Course, Cold Spring Harbor Lab, Cold Spring Harbor, USA.
2004, Course Organizer: From Structures to Networks, Watson School for Biological Sciences, Cold Spring Harbor Laboratory, Cold Spring Harbor, USA.
2002, Lecturer, Proteomics Course, Cold Spring Harbor Lab, Cold Spring Harbor, USA

Selected publications

Mangone, M., Myers, M.P., Herr, W. 2010. Role of the HCF-1 basic region in sustaining cell proliferation. PLoS One 5, e9020 PubMed link

Nagasaka, K., Pim, D., Massimi, P., Thomas, M., Tomaic, V., Subbaiah, V.K., Kranjec, C. Nakagawa, S. Yano, T., Taketani, Y. Myers, M., Banks, L. 2010. The cell polarity regulator hScrib controls ERK activation through a KIM site-dependent interaction. Oncogene 29, 5311-5321 PubMed link

Tomaić, V., Gardiol, D., Massimi, P., Ozbun, M., Myers, M., Banks, L. 2008. Human and primate tumour viruses use PDZ binding as an evolutionarily conserved mechanism of targeting cell polarity regulators. Oncogene 28, 1-8 PubMed link

Bish, R.A., Fregoso, O.I., Piccini, A., Myers, M.P. 2008. Conjugation of complex polyubiquitin chains to WRNIP1. Journal of Proteome Research 7, 3481-3489 PubMed link

Bish, R.A., Myers, M.P. 2007. Werner helicase interacting protein 1 (WRNIP1) binds polyubiquitin via its zinc finger domain. J Biol Chem. 282, 23184-23193 PubMed link

Huang, Y., Myers, M.P., Xu, R.-M. 2006. Crystal structure of the HP1-EMSY complex reveals an unusual mode of HP1 binding. Structure 14, 703-712

Narita, M., Narita, M., Krizhanovsky, V., Nuñez, S., Chicas, A., Hearn, A.A., Myers, M.P., Lowe, S.W. 2006. A novel role for high-mobility group a proteins in cellular senescence and heterochromatin formation. Cell 126, 503-514

Duelli, D.M., Hearn, S., Myers, M.P., Lazebnik. Y. 2005. A primate virus generates transformed human cells by fusion. J Cell Biol. 171, 493-503

Janardhan, A., Swigut, T., Hill, B., Myers, M.P., Skowronski, J. 2004. HIV-1 Nef binds the DOCK2-ELMO1 complex to activate rac and inhibit lymphocyte chemotaxis. PLoS Biol. 2: E6.

Salmeen, A., Andersen, J.N., Myers, M.P., Meng, T.-C., Hinks, J.A., Tonks, N.K., et al. 2003. Redox regulation of protein tyrosine phosphatase 1B involves a sulphenyl-amide intermediate. Nature 423, 769-773