Martin Trepel

Thursday, 6 September 2018 |12:00 noon

Center for Oncology, II. Medical Clinic and Polyclinic,
Hamburg, GERMANY

Targeting cell-type-specific receptors in cancer and normal tissues

(Host: S. Zacchigna)

Various cell types (such as tumor cells, endothelial cells, lung cells etc.) express specific proteins on their surface (“receptors”). Our group focuses on the identification of such cell-,organ-, or tumor-specific receptors. The goal is to exploit such specific receptors for targeted therapies.

That way, drugs can be directed to the cells of interest while healthy tissues can be spared from side effects. In addition, the knowledge about tumor-specific receptors and their ligands helps us to understand cancer biology which is often driven by specific receptor-ligand interactions.

The lecture will focus on specific receptors on lymphoma cells (B-cell receptors) and on the development of specifically cell type- targeted gene therapy vectors.