IBDM, CNRS UMR7288, Aix-Marseille Université, Campus de Luminy Case 907, Marseille cedex 9, FRANCE

Friday, 12 April 2019 | 12:00 noon

Flowers for a broken heart: Endothelial plasticity drives arterial remodeling after myocardial infarction

(Host: S. Zacchigna)

Revascularization is an important prerequisite for ischemic tissue to survive after myocardial infarction. However, innate revascularization ability is limited. Using mouse genetic tools specific to coronary arteries, we have followed arterial remodeling during myocradial infarction. Three to seven days after the infarction, bursts of new arterial endothelial cells, which formed structures described as endocardial flowers, were apparent within the endocardium. Analyses revealed that these flowers were indeed endocardial in origin, were connected to coronary artery fistulae (or stems) and gradually acquired the expression of endothelial markers.