Center for Translational Research in Oncology, Cancer Institute of São Paulo, São Paulo, BRAZIL
Epidemiological and Functional Impact of HPV-16 genetic variability
Host: G. Schafer
Persistent infections by high-risk HPVs (human papillomavirus) are associated with the
development of cervical and vulvar cancer in women, penile cancer in men, and anal
and oropharyngeal tumors in both gender. Among this group, HPV-16 is worldwide the
most prevalent type in cervical carcinomas. In neoplasias of other anogenital sites and the
oropharynx, HPV-16 is detected in almost all the tumors attributable to HPV. We and others
have shown that intra-typical nucleotide variability of HPV-16 impacts not only upon the risk
of infection persistence and disease development in both men and women, but also upon
the biological functions of viral E6 and E7 oncoproteins. These issues will be discussed in the seminar.
International Seminar Programme
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