Center for Translational Research in Oncology, Cancer Institute of São Paulo, São Paulo, BRAZIL

Epidemiological and Functional Impact of HPV-16 genetic variability

Host: G. Schafer

Persistent infections by high-risk HPVs (human papillomavirus) are associated with the

development of cervical and vulvar cancer in women, penile cancer in men, and anal

and oropharyngeal tumors in both gender. Among this group, HPV-16 is worldwide the

most prevalent type in cervical carcinomas. In neoplasias of other anogenital sites and the

oropharynx, HPV-16 is detected in almost all the tumors attributable to HPV. We and others

have shown that intra-typical nucleotide variability of HPV-16 impacts not only upon the risk

of infection persistence and disease development in both men and women, but also upon

the biological functions of viral E6 and E7 oncoproteins. These issues will be discussed in the seminar.

Hundreds of videos, tens of playlists providing free scientific content worldwide