Guy and Ann Youmans Professor and Chair , Dept. of Microbiology-Immunology, Feinberg School of Medicine Northwestern University , Chicago, IL, USA
Tuesday, 23 November 2021 | 3:00 pm – ICGEB Trieste, ITALY
HPV and DNA Damage Response
Host: L. Banks
My studies have focused on investigating the life cycle of high-risk human papillomaviruses, which are the causative agents of most anogenital and many oral cancers. Our work has identified many important mechanisms regulating viral pathogenesis. My laboratory has used tissue culture methods to grow infectious high-risk HPV virions and to study the differentiation- dependent life cycle of high-risk HPVs. These methods were used to identify the viral promoters in high-risk HPVs along with the factors regulating their transcription. Additional studies demonstrated that the E6 and E7 oncoproteins provide important functions in immortalization as well as the viral life cycle. We further demonstrated that HPVs activated the ATM and ATR DNA damage repair pathways and that this was critical for viral replication.
I have been continuously funded by the NCI since 1987 and have been the recipient of an NCI Merit award. I am the author of over 160 manuscripts and have trained 25 PhD students as well as 32 postdoctoral fellows. Many of these individuals hold faculty positions at academic institutions as well as in pharmaceutical companies. Finally, I am Chair of the Department of Microbiology-Immunology at Northwestern University and have served in this capacity for over 18 years.
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