Józef Dulak

Wednesday, 21 February 2018 |  12:00 noon

Department of Medical Biotechnology, Faculty of Biochemistry, Biophysics & Biotechnology, Jagiellonian University, Krakow, Poland & Kardio-Med Silesia, Zabrze, POLAND

Heme oxygenase-1 and microRNAs in heart and skeletal muscle repair and regeneration

(Host: M. Giacca)

Adult heart cannot regenerate efficiently unlike the skeletal muscles rebuilding thanks to the satellite cells, the bone fide stem cells. The process of repair and regeneration are affected by inflammation, which drives the initial response to the injury, but when prolonged can impair the regeneration and aggravate tissue damage. Heme oxygenase-1 (HO-1) is among the major modulators of inflammation. Previously we have shown its significance in blood vessel formation (for review see: Dulak et al, Circulation 2008; 117(2):231-41) and recently demonstrated its crucial role in regulation of microRNA biogenesis and differentiation of satellite cells (Kozakowska et al, Antioxid Redox Signal, 2011; 16(2):113- 27; Cieśla et al, Cancer Res 2016; 76(19):5707-5718.).

HO-1 is crucial for the proper vessel and muscle regeneration after hind limb ischemia (Jazwa et al, Cardiovasc Res 2013; 97(1):115-24) and it affects heart repair by modulating the influx of bone marrow and spleen-derived monocytes (Tomczyk et al, Basic Res Cardiol 2017; Jul;112(4):39). HO-1 significantly influences satellite cells function and skeletal muscle repair (Kozakowska et al. Amer J Pathol 2017; Nov 21. pii: S0002-9440(17)30471-6) and appears to be an important modulator of muscle damage, inflammation and satellite cells differentiation in Duchenne muscular dystrophy (Pietraszek, Kozakowska et al, in revision). In this talk the significance of the interactions between HO-1 and microRNAs in heart and skeletal muscle repair will be discussed.