Director of Research, Laboratorio Pasteur, Istituto Pasteur-Fondazione Cenci Bolognetti Rome, ITALY

Tuesday 18 June 2019 | 12:00 noon

Immunometabolic regulation of the innate immune response during dengue virus infection

Host: A. Marcello

Dengue virus (DENV), the leading arthropod-borne viral infection in the world, infects more than 300 million people worldwide, leading to 25-50,000 deaths annually. Markers associated with oxidative stress have been identified in patients with severe DENV infection, suggesting a relationship between oxidative stress and viral pathogenesis. Using genetic, biochemical and pharmacologic approaches, we demonstrated that the antioxidant gene network induced by Nrf2 transcription factor limited antiviral and cell death responses to DENV infection in human monocyte-derived dendritic cells. In this presentation, re-programming of the antioxidant response during DENV infection will be discussed in light of the modulation of the innate antiviral and inflammatory response, and as a target for DENV-mediated metabolic re-programming of the host response to infection.