JMB: Bhavesh and team publish first report of the molecular mechanism of RNA recognition in the Malaria parasite

The Transcription Regulation Group, ICGEB New Delhi, publishes novel data to combat Malaria.

Among vector borne diseases malaria affects the largest proportion of the world’s population. The economic consequences of this widespread disease is also apparent in that malaria endemic countries have much lower GDP growth than countries free from malaria. Most alarmingly, drug resistance in malaria is now emerging as a major threat to public health. 

In a paper recently published in ScienceDirect, by Bhavesh et al , a breakthrough has been made in understanding how the malaria parasite is able to expand the coding capacity of its genome by over 20% . This makes it far more complex than many other similar organisms and facilitates the evolution into one that is drug resistant.

Structural delineation of RNA recognition by N-terminal RNA recognition motif of SR1 protein from Plasmodium falciparum

PubMed link: This article is Open Source
The N-terminal RNA Recognition Motif of PfSR1 Confers Semi-specificity for Pyrimidines during RNA Recognition. 
J Mol Biol.
 2018 Nov 28. doi: 10.1016/j.jmb.2018.11.020 [Epub ahead of print]