Jitendra Thakur

Jitendra Thakur

Group Leader, Plant Transcription Regulation
International Centre for Genetic Engineering and Biotechnology
Aruna Asaf Ali Marg
110 067 New Delhi, India
E-mail: [email protected]

Education

Department of Marine Biotechnology, Goa University, India, MSc, 1996
Department of Plant Molecular Biology, University of Delhi, India, MPhil, 1999
Department of Plant Molecular Biology, University of Delhi, India, PhD, 2003

Career History

Since 2021 – Group Leader, Plant Transcription Regulation, International Centre for Genetic Engineering and Biotechnology (ICGEB), New Delhi, India
2009-2021, Staff Scientist, National Institute of Plant Genome Research (NIPGR), New Delhi, India
2014 – Visiting Faculty, Department of Biochemistry & Cellular & Molecular Biology, University of Tennessee, Knoxville, USA
2008-2009, Assistant Professor, Indian Institute of Science and Education Research – Kolkata, India
2004-2008, Research Associate, Harvard Medical School/MGH Cancer Center, Boston, USA

Scientific Activity

The main interest of the group is to understand transcriptional regulation of gene expression in plants focusing mainly, but not limited to, on the functioning of Mediator complex. We employ tools of molecular biology, biochemistry, genomics and bioinformatics for this purpose. Arabidopsis and rice are used as the model systems in our studies. The group is also interested in understanding the epigenetics landscape during seed development.

Selected publications

Bhardwaj, R., Thakur, J.K., Kumar, S. 2021. MedProDB: A database of Mediator proteins. Comput Struct Biotechnol J 19, 4165-4176

Agrawal R, Fajkus J and Thakur JK (2021) Kinase module of Mediator complex: Important signalling processor for development and survival of plants. Journal of Experimental Botany 72: 224-240.

Kumar A, Daware A, Kumar A, Kumar V, Krishnan S Gopala, Mondal S, Patra BC, Singh AK, Tyagi AK, Parida SK and Thakur JK (2020). Genome-wide analysis of polymorphisms identified domestication-associated low diversity region carrying important grain size QTL. Plant Journal 103: 1525-1547.

Dwivedi N, Maji S, Waseem M, Kumar V, Parida SK and Thakur JK (2019) The Mediator subunit OsMed15a is a transcriptional co-regulator of seed size/weight-modulating genes in rice. Biochimica et Biophysica Acta – Gene Regulatory Mechanism 1862: 194432.

Maji S, Dahiya P, Waseem M, Dwivedi N, Bhat DS, Dar T and Thakur JK (2019) Interaction map of Arabidopsis Mediator complex expounding its topology. Nucleic Acids Research 47: 3904-3920.

Kumar V, Waseem M, Dwivedi N, Maji S, Kumar A and Thakur JK (2018) KIX domain of AtMed15a, a Mediator subunit of Arabidopsis is required for its interaction with different proteins. Plant Signal Behav 13(2): e1428514

Nagulapalli M, Maji S, Dwivedi N, Dahiya P and Thakur JK (2016) Evolution of disorder in Mediator complex and its functional relevance. Nucleic Acids Research 44: 1591-1612.

Thakur JK, Yadav A and Yadav G (2014) Molecular recognition by the KIX domain and its role in gene regulation. Nucleic Acids Research 42: 2112-2125.

Naar AM and Thakur JK (2009) Nuclear Receptor-Like transcription factors in fungi. Genes & Development 23:419-32.

Thakur JK, Arthanari H, Yang F, Pan S, Fan X, Breger J, Frueh DP, Gulshan K, Li DK, Mylonakis E, Struhl K, Moye-Rowley SW, Cormack BP, Wagner G and Naar AM (2008) A nuclear-receptor-like pathway regulating multidrug resistance in fungi. Nature 452: 604-609.

Patent:

Recombinant microorganisms and uses thereof. Inventors; Thakur JK, Dahiya P and Bhat D. Patent No. 326127, Application No. 3699/DEL/2012.