Dept. Biology and Biotechnology “C. Darwin” Center for Life Nano- & Neuro-Science, Fondazione Istituto Italiano di Tecnologia, Sapienza, University of Rome, ITALY
The Role of RNA in Neurodegenerative Diseases: From Mechanisms to Therapy in ALS
Host: L. Banks
Abstract
Recent works indicate the pathogenic relevance of altered RNA metabolism and aberrant ribonucleoprotein (RNP) assembly in several neurodegenerative diseases, such as Amyotrophic lateral sclerosis. How defective RNPs form, what are their integral components and which events trigger their appearance late in life are still unsolved issues. While emerging evidence indicates that mutations and post-translational modifications of specific RNA-binding proteins (RBPs) induce liquid-solid phase transition in vitro, much less is known about the in vivo properties of RNP assemblies, and which role RNA plays in their formation.
Our studies combine imaging-derived RNP complex purification with innovative computational approaches and powerful genetic tools to unravel the biophysical properties and composition of RBP complexes and how they are modified in disease conditions.
International Seminar Programme
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