InfraRed for Frontal Temporal Dementia – IR4FTD

Frontal Temporal Dementia (FTD) is the second most common dementia and usually affects individuals younger than 60 years old. FTD is difficult to diagnose, since there is no single exam that determines the disease, but instead many costly or painful exams that together link the disease. Some of the symptoms of the disease may be confounding with others such as Alzheimer’s Disease (AD). While the usual search for biomarkers focuses on individual patterns, the present proposal is to use a holistic approach. Vibrational spectroscopy provides a snapshot of the entire sample in a label-free way. In particular, infrared and Raman spectroscopy among other techniques will be used in a multimodal way to identify a vibrational fingerprint for Frontal Temporal Dementia on biofluid markers. Saliva and plasma will be the main targets for this study. Data will be analyzed by using Machine Learning approaches. These project’s findings will pave the way to the development of a new screening tool that would decrease the costs associated with the current diagnosis of FTD and in general for neurodegenerative disorders.

This project is funded by the European Union thanks to a Marie Sklodowska Curie Global Fellowship granted to Dr. Diana E. Bedolla.

Who is Dr. Diana E. Bedolla?

Dr. Diana Bedolla in the lab with Dr. Emanuele Buratti, Molecular Pathology Group Leader, ICGEB Trieste
Dr. Diana Bedolla in the lab with Dr. Emanuele Buratti, Molecular Pathology Group Leader, ICGEB Trieste

We are a group of people who believe that only interdisciplinarity, collaboration, a positive attitude and a lot of work can bring good results to this research and to humanity. Therefore, if you are interested in the topic and you can contribute with these four characteristics, please contact us (hyperlink: mailto: [email protected]).

Dr. Diana E. Bedolla, MSCA Fellow

Partnership

In order for this project to succeed, several world experts were gathered for this project.

Prof. Emanuele Buratti, Molecular Pathology, ICGEB Trieste, Italy

Prof. Bayden Wood, School of Chemistry, Monash University, Melbourne, Australia

Dr. Lisa Vaccari, IDEAS and SISSI Beamlines, Elettra Sincrotrone Trieste, Italy, and

Spedali Civili di Brescia.