Chikungunya and dengue are arboviral infections with overlapping clinical symptoms.
A subset of chikungunya infection occurs also as co-infections with dengue, resulting in complications during diagnosis and patient management.
The study by PIs at ICGEB New Delhi was undertaken to identify the global metabolome of patient sera infected with chikungunya as mono infections and with dengue as co-infections. Using nuclear magnetic resonance (NMR) spectroscopy, the metabolome of sera of three disease conditions, namely, chikungunya and dengue as mono-infections and when co-infected were ascertained and compared with healthy individuals.
The cohorts were analyzed on the basis of age, onset of fever and joint involvement. They show that many metabolites in the serum are significantly differentially regulated during chikungunya mono-infection as well as during chikungunya co-infection with dengue and observed that glycine, serine, threonine, galactose and pyrimidine metabolisms are the most perturbed pathways in both mono and co-infection conditions. The affected pathways in the study correlate well with the clinical manifestation like fever, inflammation, energy deprivation and joint pain during the infections.
These results may serve as a starting point for validations and identification of distinct biomolecules that could be exploited as biomarker candidates thereby helping in better patient management.
Article in Open Source on PubMed
26 January 2018
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The Hindu: ICGEB finds distinct biomarkers for dengue and chikungunya
Nature: Scientific Reports – Article in Open Source: ICGEB New Delhi researchers on dengue and chikungunyaR