Marco Baralle

Group Leader, RNA Biology

International Centre for Genetic Engineering and Biotechnology
Padriciano 99
34149 Trieste, Italy
E-mail: [email protected]
Tel: +39-040-3757337


University College London, London, England, BSc Biochemistry, 1992
University of London, London, England, PhD, 2000

Career History

Since 2018, Group Leader, RNA Biology Group, ICGEB, Trieste, Italy
2013-2017, Group Leader, Biotechnology Development Group, ICGEB, Trieste, Italy
2003-2013, Research Scientist, Biotechnology Development Group, ICGEB, Trieste, Italy

Scientific Activity

Since beginning his postdoctoral work Dr. Baralle’s interests have been the role of RNA splicing in genetic disease with particular interest in how in the mechanism of splicing is affected by gene mutations, what this teaches us about the complex mechanism and role of splicing. Uniting his 5 years as head of the Biotechnology group, where he concentrated on Biological proteins of Pharmaceutical interest, he focuses on how the knowledge of these mechanisms can be used to prevent or alter disease.

Selected Publications

Baralle, M. and Baralle, F.E. (2018) The splicing code. Bio Systems, 164, 39-48.

De Conti, L., Borroni, B. and Baralle, M. (2017) New routes in frontotemporal dementia drug discovery. Expert opinion on drug discovery, 12, 659-671.

De Conti, L., Baralle, M. and Buratti, E. (2017) Neurodegeneration and RNA-binding proteins. Wiley interdisciplinary reviews. RNA, 8.

Zampieri, D., Mamolo, M.G., Vio, L., Romano, M., Skoko, N., Baralle, M., Pau, V. and De Logu, A. (2016) Antimycobacterial activity of new N(1)-[1-[1-aryl-3-[4-(1H-imidazol-1-yl)phenyl]-3-oxo]propyl]-pyridine-2-carboxami drazone derivatives. Bioorganic & medicinal chemistry letters, 26, 3287-3290.

Skoko, N., Baralle, M. and Baralle, F.E. (2016) Absence of TDP-43 is difficult to digest. The EMBO journal, 35, 115-117.

Prpar Mihevc, S., Baralle, M., Buratti, E. and Rogelj, B. (2016) TDP-43 aggregation mirrors TDP-43 knockdown, affecting the expression levels of a common set of proteins. Scientific reports, 6, 33996.

Polez, S., Origi, D., Zahariev, S., Guarnaccia, C., Tisminetzky, S.G., Skoko, N. and Baralle, M. (2016) A Simplified and Efficient Process for Insulin Production in Pichia pastoris. PloS one, 11, e0167207.

Mompean, M., Baralle, M., Buratti, E. and Laurents, D.V. (2016) An Amyloid-Like Pathological Conformation of TDP-43 Is Stabilized by Hypercooperative Hydrogen Bonds. Frontiers in molecular neuroscience, 9, 125.

Hernandez-Imaz, E., Martin, Y., de Conti, L., Melean, G., Valero, A., Baralle, M. and Hernandez-Chico, C. (2015) Functional Analysis of Mutations in Exon 9 of NF1 Reveals the Presence of Several Elements Regulating Splicing. PloS one, 10, e0141735.

Granata, B.X., Baralle, M., De Conti, L., Parera, V. and Rossetti, M.V. (2015) Characterization of variegate porphyria mutations using a minigene approach. JIMD reports, 20, 39-44.

De Conti, L., Akinyi, M.V., Mendoza-Maldonado, R., Romano, M., Baralle, M. and Buratti, E. (2015) TDP-43 affects splicing profiles and isoform production of genes involved in the apoptotic and mitotic cellular pathways. Nucleic acids research, 43, 8990-9005.

Cragnaz, L., Klima, R., De Conti, L., Romano, G., Feiguin, F., Buratti, E., Baralle, M. and Baralle, F.E. (2015) An age-related reduction of brain TBPH/TDP-43 levels precedes the onset of locomotion defects in a Drosophila ALS model. Neuroscience, 311, 415-421.

Falanga, A., Stojanovic, O., Kiffer-Moreira, T., Pinto, S., Millan, J.L., Vlahovicek, K. and Baralle, M. (2014) Exonic splicing signals impose constraints upon the evolution of enzymatic activity. Nucleic acids research, 42, 5790-5798.

Bembich, S., Herzog, J.S., De Conti, L., Stuani, C., Avendano-Vazquez, S.E., Buratti, E., Baralle, M. and Baralle, F.E. (2014) Predominance of spliceosomal complex formation over polyadenylation site selection in TDP-43 autoregulation. Nucleic acids research, 42, 3362-3371.

Nuzzo, F., Radu, C., Baralle, M., Spiezia, L., Hackeng, T.M., Simioni, P. and Castoldi, E. (2013) Antisense-based RNA therapy of factor V deficiency: in vitro and ex vivo rescue of a F5 deep-intronic splicing mutation. Blood, 122, 3825-3831.

De Conti, L., Baralle, M. and Buratti, E. (2013) Exon and intron definition in pre-mRNA splicing. Wiley interdisciplinary reviews. RNA, 4, 49-60.

Buratti, E., Baralle, M. and Baralle, F.E. (2013) From single splicing events to thousands: the ambiguous step forward in splicing research. Briefings in functional genomics, 12, 3-12.

Baralle, M., Buratti, E. and Baralle, F.E. (2013) The role of TDP-43 in the pathogenesis of ALS and FTLD. Biochemical Society transactions, 41, 1536-1540.

Zubovic, L., Baralle, M. and Baralle, F.E. (2012) Mutually exclusive splicing regulates the Nav 1.6 sodium channel function through a combinatorial mechanism that involves three distinct splicing regulatory elements and their ligands. Nucleic acids research, 40, 6255-6269.