Gorazd Stokin

Friday, 22 June 12:00 noon

St. Anne’s University Hospital Brno, International Clinical Research Center, Brno, CZECH REPUBLIC

Axons, transport, Alzheimer’s disease and beyond

(Host: E. Buratti)

Alzheimer’s disease is the most commonneurodegenerative disorder resulting in dementiain the elderly. Clinically, it consists in acquiredprogressive behavioural changes and cognitivedecline, while pathologically it is characterised bysynaptic and neuronal loss. Senile plaques, whichconsist in aberrant extracellular accumulationof amyloid peptides, and neurofibrillary tangles,which consist equally in aberrant, but in this caseintracellular accumulation of hyperphosphorylated tau, represent the pathological hallmarks of Alzheimer’s disease.

Intriguingly, senile plaques andneurofibrillary tangles, are both linked to axonalpathology and impairments in axonal transport.Microtubule-dependent axonal transport canbe divided into anterograde and retrogradewith mechanisms of its regulation and its role inAlzheimer’s disease still to be elucidated. This istrue also for the basic mechanisms underlyingaxonal pathology formation in Alzheimer’s diseasein beyond.