Giovanni Sorrentino

Group Leader, Advanced Disease Models
International Centre for Genetic Engineering and Biotechnology
Padriciano 99
34149 Trieste, Italy
E-mail: [email protected]

Education

University of Trieste, Italy, PhD in Molecular Biomedicine, 2014
University of Ferrara, Italy, MSc IN Medical-Pharmaceutical Biotechnology, 2008

Career History

Since 2023, Group Leader, Advanced Disease Models, ICGEB Trieste, Italy
Since 2021, Head of the AIRC Start-Up Unit, University of Trieste, Italy
2017-2020, FEBS long-term postdoctoral fellow, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland
2014-2016 Italian Foundation for Cancer Research (FIRC) postdoctoral fellow, National Laboratory CIB, Trieste, Italy

Scientific Activity

Dr. Sorrentino’s research is dedicated to unraveling the fundamental principles that govern the progression of chronic liver diseases, with the overarching goal of applying this knowledge to create innovative disease models, advance cancer treatments, and develop regenerative medicine therapies. His laboratory’s primary focus is to investigate how metabolic and nutritional signals orchestrate mechanical interactions within hepatic tissue, thereby influencing stem cell behavior and the development of cancer. These basic biological questions are approached by combining mouse models, tissue engineering techniques, and 3D organotypic cultures derived from both adult tissues and human induced pluripotent stem cells.

Currently, Dr. Sorrentino’s research delves into multiple areas of interest, including the mechanisms of metabolic reprogramming in liver stem cells, innovative strategies for exploring how liver cells perceive mechanical cues in the context of cancer, and novel approaches to model multifactorial metabolic and genetic liver diseases ex vivo. These investigations contribute to a deeper understanding of liver health and disease, with the potential to pave the way for groundbreaking advancements in medical research and treatment.

Teaching Activity

Since 2022, Assistant Professor of Histology, Department of Medical, Surgical and Health Sciences, University of Trieste, Italy

Selected Publications

Ece, Y. et al. Hepatic lipid overload potentiates biliary epithelial cell activation via E2Fs. eLife 11, (2022).

Sorrentino, G. et al. Bile Acids Signal via TGR5 to Activate Intestinal Stem Cells and Epithelial Regeneration. Gastroenterology 159, 956-968.e8 (2020).

Sorrentino, G. et al. Mechano-modulatory synthetic niches for liver organoid derivation. Nat Commun 11, 3416 (2020).

Lund, M. L. et al. L-Cell Differentiation Is Induced by Bile Acids Through GPBAR1 and Paracrine GLP-1 and Serotonin Signaling. Diabetes 69, 614–623 (2020).

Sorrentino, G. et al. Glucocorticoid receptor signalling activates YAP in breast cancer. Nat Commun 8, 14073 (2017).

Sorrentino, G. et al. Metabolic control of YAP and TAZ by the mevalonate pathway. Nat Cell Biol 16, 357–366 (2014).