Assistant Professor, Head of Molecular Liver Pathophysiology Unit Department of Medical, Surgical and Health Sciences – University of Trieste, ITALY

Modeling complex liver diseases using advanced organotypic cultures

Host: A. Muro

Dr. Sorrentino’s research is oriented at understanding the fundamental principles that regulate chronic liver diseases progression, with the ultimate goal of translating this knowledge to design innovative disease models, cancer treatments and regenerative medicine therapies. In particular, his lab is exploring how metabolic and nutritional cues coordinate mechanical communication within the hepatic tissue to control stemness and cancer development. These basic biological questions are approached by combining mouse models, tissue engineering techniques, and 3D organotypic cultures derived from both adult tissues and human induced pluripotent stem cells.

During the seminar, Dr. Sorrentino will discuss mechanisms of metabolic reprogramming in liver stem cells, innovative strategies to investigate liver cell mechano-perception as well as novel approaches to model multi-factorial metabolic and genetic liver diseases ex vivo.


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