Giovanni LIGRESTI

Boston University Chobanian & Avedisian School of Medicine,

Boston, MA USA

Contribution of vascular aging to lung repair and fibrosis

Host: L. Braga

Brief Abstract:

Idiopathic pulmonary fibrosis (IPF) is a fatal disease of the lung associated with aging.

Although IPF is characterized by several vascular abnormalities, the contribution of

the pulmonary vasculature to the pathogenesis of IPF remains poorly understood.

Our laboratory employs multi-omics, genetic and lineage tracing approaches to in-

vestigate how aging-associated vascular dysfunction contributes to the pathogenesis

of IPF. Our ultimate goal is to identify key targetable mechanisms driving IPF progres-

sion toward our long-term goal of blocking or reversing this lung condition.

Short Bio:

I am an Associate Professor in the Department of Medicine at Boston University. My

research focuses on lung injury, repair and fibrosis and I have studied several patho-

logical mechanisms driving pulmonary fibrosis including vessel remodeling and my-

ofibroblast differentiation. Currently, my laboratory focuses on understanding how

aging-associated epigenetic mechanisms driving persistent fibrogenesis in idiopathic

pulmonary fibrosis.

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