MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford UK

Host: F. Benvenuti

Harnessing Runx1 enhancer-reporter model to elucidate the specification of HSC in the mouse embryo

Brief Abstract

During embryogenesis, hematopoietic stem cells (HSC) are found within intra-aortic

hematopoietic clusters (IAHC) emerging from the ventral wall of the dorsal aorta. IAHC are

very heterogenous and contain both transplantable HSC and hematopoietic progenitor cells

(HPC) devoid of repopulation potential. However, the early events driving the specification

of these alterative fates are still poorly characterised. To better understand this process, we

made use of two enhancer-reporter mouse models enabling the isolation and multiomic

profiling of single IAHC cells to generate a cell type-specific gene regulatory network (GRN) of

nascent HSCs. Our results will inform new strategies for the in vitro generation of functional


Short Bio

I obtained my PhD in Immunology from King’s College London studying dendritic cell (DC)

biology and developing novel approaches to support their differentiation in vitro in Dr Pierre

Guermonprez lab. I am currently a postdoctoral scientist in Prof. Marella De Bruijn lab at the

Weatherall Institute of Molecular Medicine (University of Oxford). Here I have been working

on understanding the early events that lead to the development of the hematopoietic system

during embryogenesis, by studying the hematopoietic niches where the first stem cells

originate and the gene regulatory networks driving the embryonic hematopoietic program.

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