Frank Brombacher

Group Leader,Cytokines and Disease
Scientific Coordinator, Immunology and Infectious Diseases, ICGEB Cape Town
International Centre for Genetic Engineering and Biotechnology
Wernher and Beit Building (South), Room S1.27,
Anzio Road, Observatory 7925
Cape Town, South Africa
E-mail: frank.brombacher@icgeb.org 
Tel: +27-21-4066147/6616

Education

University of Freiburg, Diploma in Molecular Biology, 1986
Max-Planck Institute for Immunobiology, Freiburg, PhD, 1989

Career History

Since May 2008, Coordinator of Immunology and Infectious Diseases, ICGEB Cape Town, South Africa
2008-present, South African Research Chair (SARCHi) in Immunology of Infectious Diseases in Africa
2000-present, Director Medical Research Unit, Medical Research Centre (MRC), South Africa
2003-2008, Member, Institute of Infectious Disease and Molecular Medicine (IIDMM), UCT, South Africa
2000-2008, Head, Division of Immunology (acting), UCT, South Africa (except 2004-2005)
2000-2004, International Wellcome Trust Senior Fellow for Medicine in Africa
1998-2000, Group leader Infectious Disease Unit, Division of Immunology, UCT, South Africa
1994-1998, Group leader, Molecular Immunology, Max-Planck-Institute for Immunobiology, Germany
1991-1993, Research Fellow, Preclinical Research Group of Sandoz Ltd, Switzerland
1989-1991, Postdoctoral Fellow, Max-Planck-Institute for Immunobiology, Germany

Scientific Activity

Research interests are general immunological mechanisms of host protection in human diseases, including Tuberculosis, Listeriosis, African Trypanosomiasis, leishmaniasis and schistosomiasis, four of the major WHO declared threats to combat. Major general topics include cytokine network and regulation, lymphocytes differentiation and function, dendritic cell and macrophage activation, as well as the role of non-immunological effector cells in health/disease like smooth muscle cells, goblet cells, activated by IL-4 and IL13.

Teaching Activity

Since 2001, Full Professor, University of Cape Town, South Africa.
2000-present, Visiting Professor University of Strathclyde, UK.
1998-2001, Associate Professor, University of Cape Town, South Africa.
1997-2000, Honorary Lecturer, University of Strathclyde, UK.

Selected publications

Darby MG, Chetty A, Mrjden D, Rolot M, Smith K, Mackowiak C, Sedda D, Nyangahu D, Jaspan H, Toellner KM, Waisman A, Quesniaux V, Ryffel B, Cunningham AF, Dewals BG, Brombacher F, Horsnell WGC. 2019. Pre-conception maternal helminth infection transfers via nursing long-lasting cellular immunity against helminths to offspring. Sci Adv. 5:eaav3058.

Leyva-Castillo JM, Galand C, Kam C, Burton O, Gurish M, Musser MA, Goldsmith JD, Hait E, Nurko S, Brombacher F, Dong C, Finkelman FD, Lee RT, Ziegler S, Chiu I, Austen KF, Geha RS. 2019. Mechanical Skin Injury Promotes Food Anaphylaxis by Driving Intestinal Mast Cell Expansion. Immunity. 50:1262-1275.

Ogrinc Wagner A, Friedrich V, Barthels C, Marconi P, Blutke A, Brombacher F, Brocker T. 2019. Strain specific maturation of Dendritic cells and production of IL-1β controls CD40-driven colitis. PLoS One. 14:e0210998.

Tamgue O, Gcanga L, Ozturk M, Whitehead L, Pillay S, Jacobs R, Roy S, Schmeier S, Davids M, Medvedeva YA, Dheda K, Suzuki H, Brombacher F, Guler R. 2019. Differential Targeting of c-Maf, Bach-1, and Elmo-1 by microRNA-143 and microRNA-365 Promotes the Intracellular Growth of Mycobacterium tuberculosis in Alternatively IL-4/IL-13 Activated Macrophages. Front Immunol. 10:421

Denisenko E, Guler R, Mhlanga M, Suzuki H, Brombacher F, Schmeier S. 2019. Transcriptionally induced enhancers in the macrophage immune response to Mycobacterium tuberculosis infection. BMC Genomics.20:71. (IF 2017 =3.730)

Ogrinc Wagner A, Friedrich V, Barthels C, Marconi P, Blutke A, Brombacher F, Brocker T. 2019. Strain specific maturation of Dendritic cells and production of IL-1β controls CD40-driven colitis. PLoS One. 14:e0210998.  (IF 2017 =2.766)

Guler R, Mpotje T, Ozturk M, Nono JK, Parihar SP, Chia JE, Abdel Aziz N, Hlaka L, Kumar S, Roy S, Penn-Nicholson A, Hanekom WA, Zak DE, Scriba TJ, Suzuki H, Brombacher F. 2019. Batf2 differentially regulates tissue immunopathology in Type 1 and Type 2 diseases. Mucosal Immunol. 12:390-402 (IF 2017 = 7.36)

Parihar SP, Guler R, Brombacher F. 2019. Statins: a viable candidate for host-directed therapy against infectious diseases. Nat Rev Immunol. 19:104-117 (IF 2017 = 46.507)

Ndlovu H, Nono JK, Abdel Aziz N, Nieuwenhuizen NE, Brombacher F. 2018. Interleukin-4 Receptor Alpha Expressing B Cells Are Essential to Down-Modulate Host Granulomatous Inflammation During Schistosomasis. Front Immunol. 9:2928. (IF 2017 =6.429)

Kamdem SD, Moyou-Somo R, Brombacher F, Nono JK. 2018. Host Regulators of Liver Fibrosis During Human Schistosomiasis. Front Immunol. 9:2781. (IF 2017 =6.429)

Ndlovu H, Nono JK, Nieuwenhuizen NE, Brombacher F. 2018. IL-4Rα-expressing CD11c+ cells contribute to driving optimal cellular responses during Schistosoma mansoni infection in mice. J Leukoc Biol. 2018 Nov 30. doi: 10.1002/JLB.MA0318-115R. [Epub ahead of print] (IF 2017 = 4.224)

Abdel Aziz N, Nono JK, Mpotje T, Brombacher F. 2018. The Foxp3+ regulatory T-cell population requires IL-4Rα signaling to control inflammation during helminth infections. PLoS Biol. 16:e2005850. (IF 2017 =9.163)

Rolot M, Dougall AM, Chetty A, Javaux J, Chen T, Xiao X, Machiels B, Selkirk ME, Maizels RM, Hokke C, Denis O, Brombacher F, Vanderplasschen A, Gillet L, Horsnell WGC, Dewals BG. 2018. Helminth-induced IL-4 expands bystander memory CD8+ T cells for early control of viral infection. Nat Commun. 9:4516. (IF 2017 =9.163)

Govender M, Hurdayal R, Salazar BM, Gqada K, Pillay S, Gcanga L, Passelli K, Nieuwenhuizen NE, Tacchini-Cottier F, Guler R, Brombacher F. 2018. Deletion of IL-4 Receptor alpha-responsive keratinocytes in BALB/c mice does not alter susceptibility to cutaneous leishmaniasis. Infect Immun. Oct 1. pii: IAI.00710-18. doi: (IF 2017 =3.256)

Nono JK, Kamdem SD, Netongo PM, Dabee S, Schomaker M, Oumarou A, Brombacher F, Moyou-Somo R. 2018. Schistosomiasis Burden and Its Association With Lower Measles Vaccine Responses in School Children From Rural Cameroon. Front Immunol. 9:2295. . (IF 2017 =6.429)

De Oliveira T, Ramakrishnan M, Diamanti MA, Ziegler PK, Brombacher F, Greten FR. 2018. Loss of Stat6 affects chromatin condensation in intestinal epithelial cells causing diverse outcome in murine models of inflammation-associated and sporadic coloncarcinogenesis. Oncogene. Oct 23. doi: 10.1038/s41388-018-0551-2. [Epub ahead of print] (2017 IF 6.854)

Barichievy S, Naidoo J, Boullé M, Scholefield J, Parihar SP, Coussens AK, Brombacher F, Sigal A, Mhlanga MM. 2018. Viral Apoptosis Evasion via the MAPK Pathway by Use of a Host Long Noncoding RNA. Front Cell Infect Microbiol. 8:263. (2017 IF 3.520)

Dzhivhuho GARehrl SANdlovu HHorsnell WGCBrombacher FWilliamson ALChege GK. 2018. Chronic schistosomiasis suppresses HIV-specific responses to DNA-MVA and MVA-gp140 Env vaccine regimens despite antihelminthic treatment and increases helminth-associated pathology in a mouse model. PLoS Pathog. 14:e1007182. (2017 IF 6.158)

Roy S, Schmeier S, Kaczkowski B, Arner E, Alam T, Ozturk M, Tamgue O, Parihar SP, Kawaji H, Itoh M, Lassmann T, Carninci P, Hayashizaki Y, Forrest ARR, Guler R, Bajic VB, Brombacher F, Suzuki H. 2018. Transcriptional landscape of Mycobacterium tuberculosis infection in macrophage. Sci Rep. 8:6758. (IF 2017 4.122)

Hadebe S, Brombacher F, Brown GD. 2018. C-Type Lectin Receptors in Asthma.

Front Immunol. 9:733. (IF 2017 =6.429)

Noviski M, Mueller JL, Satterthwaite A, Garrett-Sinha LA, Brombacher F, Zikherman J. 2018. IgM and IgD B cell receptors differentially respond to endogenous antigens and control B cell fate. Elife. Mar 7: e35074. (Impact factor 2017 7.616)

Weng SY, Wang X, Vijayan S, Tang Y, Kim YO, Padberg K, Regen T, Molokanova O, Chen T, Bopp T, Schild H, Brombacher F, Crosby JR, McCaleb ML, Waisman A, Bockamp E, Schuppan D. 2018. IL-4 Receptor Alpha Signaling through Macrophages Differentially Regulates Liver Fibrosis Progression and Reversal. EBioMedicine.  29:92-103 (IF=6.183))

Brombacher TM, De Gouveia KS, Cruywagen L, Makena N, Booley F, Tamgue O, Brombacher F. 2018. Nippostrongylus brasiliensis infection leads to impaired reference memory and myeloid cell interference. Sci Rep. 8:2958. (IF 2017 4.847)

Firacative C, Gressler AE, Schubert K, Schulze B, Müller U, Brombacher F, von Bergen M, Alber G. 2018. Identification of T helper (Th)1- and Th2-associated antigens of Cryptococcus neoformans in a murine model of pulmonary infection. Sci Rep. 8:2681. (IF 2017 4.847)

Nieuwenhuizen N, Kirstein F, Hoving JC, Brombacher F. 2018. House dust mite induced allergic airway disease is attenuated in CD11ccreIL-4Rαmice. Sci Rep. 8:885. (IF 2017 4.847)

Hurdayal R, Brombacher F. 2017. Interleukin-4 Receptor Alpha: From Innate to Adaptive Immunity in Murine Models of Cutaneous Leishmaniasis. Front Immunol. 8:1354 (IF 2017 =6.429)

Descatoire M, Hurrell BP, Govender M, Passelli K, Martinez-Salazar B, Hurdayal R, Brombacher F, Guler R, Tacchini-Cottier F. 2017. IL-4Rα Signaling in Keratinocytes and Early IL-4 Production Are Dispensable for Generating a Curative T Helper 1 Response in Leishmania major-Infected C57BL/6 Mice. Front Immunol. 8:1265. (IF 2017 =6.429)

Denisenko E, Guler R, Mhlanga MM, Suzuki H, Brombacher F, Schmeier S. 2017. Genome-wide profiling of transcribed enhancers during macrophage activation. Epigenetics Chromatin. 10:50. 1354 (IF 2017 =5.333)

Hlaka LRosslee MJOzturk MKumar SParihar SPBrombacher FKhalaf AICarter KCScott FJSuckling CJGuler R. 2017. Evaluation of minor groove binders (MGBs) as novel anti-mycobacterial agents and the effect of using non-ionic surfactant vesicles as a delivery system to improve their efficacy. J Antimicrob Chemother.  72:3334-3341 (IF 2017 =5.313)

Hurdayal R, Ndlovu HH, Revaz-Breton M, Parihar SP, Nono JK, Govender M, Brombacher F. 2017. IL-4-producing B cells regulate T helper cell dichotomy in type 1- and type 2-controlled diseases. Proc Natl Acad Sci U S A. 114: E8430-E8439. (IF 2017 =9.661)

Oetjen LK, Mack MR, Feng J, Whelan TM, Niu H, Guo CJ, Chen S, Trier AM, Xu AZ, Tripathi SV, Luo J, Gao X, Yang L, Hamilton SL, Wang PL, Brestoff JR, Council ML, Brasington R, Schaffer A, Brombacher F, Hsieh CS, Gereau RW 4th, Miller MJ, Chen ZF, Hu H, Davidson S, Liu Q, Kim BS. 2017. Sensory Neurons Co-opt Classical Immune Signaling Pathways to Mediate Chronic Itch. Cell. 171:217-228 (IF 2017 =30.410)

Noguchi, S. et al. 2017. FANTOM5 CAGE profiles of human and mouse samples. Sci. Data 4:170112. (IF 2017 =4.83)

Parihar SP, Ozturk M, Marakalala MJ, Loots DT, Hurdayal R, Beukes D, Van Reenen M, Zak DE, Mbandi SK, Darboe F, Penn-Nicholson A, Hanekom WA, Leitges M, Scriba TJ, Guler R, Brombacher F. 2017. Protein kinase C-delta (PKCδ), a marker of inflammation and tuberculosis disease progression in humans, is important for optimal macrophage killing effector functions and survival in mice. Mucosal Immunol. 11:579. (IF 2017 =7.374)

Nono JK, Ndlovu H, Abdel Aziz N, Mpotje T, Hlaka L, Brombacher F. 2017. Host regulation of liver fibroproliferative pathology during experimental schistosomiasis via interleukin-4 receptor alpha. PLoS Negl Trop Dis. 11:e0005861. (IF 2017 =3.948)

White AJ, Baik S, Parnell SM, Holland AM, Brombacher F, Jenkinson WE, Anderson G. 2017. A type 2 cytokine axis for thymus emigration. J Exp Med. 214:2205-16. (IF 2017 11.991)

Nono JK, Ndlovu H, Abdel Aziz N, Mpotje T, Hlaka L, Brombacher F. 2017. Interleukin-4 receptor alpha is still required after Th2 polarization for the maintenance and the recall of protective immunity to Nematode infection. PLoS Negl Trop Dis. 11:e0005675. (IF 2017 =3.948)

Scott FJ, Nichol RJO, Khalaf AI, Giordani F, Gillingwater K, Ramu S, Elliott A, Zuegg J, Duffy P, Rosslee MJ, Hlaka L, Kumar S, Ozturk M, Brombacher F, Barrett M, Guler R, Suckling CJ. 2017. An evaluation of Minor Groove Binders as anti-fungal and anti-mycobacterial therapeutics. Eur J Med Chem. 136:561-572. (IF 2017 =4.5219)

Pelly VS, Coomes SM, Kannan Y, Gialitakis M, Entwistle LJ, Perez-Lloret J, Czieso S, Okoye IS, Rückerl D, Allen JE, Brombacher F, Wilson MS. 2017. Interleukin 4 promotes the development of ex-Foxp3 Th2 cells during immunity to intestinal helminths. J Exp Med. 23:623-30. (IF 2017 11.991)

Fischer K, HH Ruiz, K Jhun, B Finan, DJ Oberlin, V van der Heide, A V Kalinovich, N Petrovic, Y Wolf, C Clemmensen, A C Shin, S Divanovic, F Brombacher, E Glasmacher, S Keipert, M Jastroch,
J Nagler, K-W Schramm, D Medrikova, G Collden, S C Woods, S Herzig, D Homan, S Jung, J Nedergaard, B Cannon, MH Tschöp, T D Müller & C Buettner 2017. Alternatively activated macrophages do not synthesize catecholamines or contribute to adipose tissue adaptive thermogenesis. Nature Medicine, 23:623-30(IF 2017 29.886)

Hoving JC, Cutler AJ, Leeto M, Horsnell WG, Dewals BG, Nieuwenhuizen NE, Brombacher F. 2017. Interleukin 13-mediated colitis in the absence of IL-4Ra signalling. Gut. 66: 2037-2039. (2016 IF 16.958)

Ng Kuet Leong N, Brombacher F, Dalpke AH, Weitnauer M. 2017. Crosstalk between glucocorticoids and IL-4 modulates YM1 expression in alternatively activated myeloid cells. Immunobiology. 222:759-67. (2015 IF 2.7)

Brombacher, T.M., J.K. Nono K.S. De Gouveia, N. Makena, M. Darby, J. Womersley, O. Tamgue, and F. Brombacher  2017. IL-13–Mediated Regulation of Learning and Memory. Journal of Immunology, 198:2681-88 (2015 IF 5.2)

Denisenko, E, D. Ho, O. Tamgue, M. Ozturk, H. Suzuki, F. Brombacher, R Guler, S. Schmeier. 2016 IRNdb: the database of immunologically relevant non-coding RNA’s. Database. 1-9. (2015 IF 2.6)

Parihar SP, Hartley MA, Hurdayal R, Guler R, Brombacher F. Topical Simvastatin as Host-Directed Therapy against Severity of Cutaneous Leishmaniasis in Mice. 2016. Sci Rep. 6:33458. (2016 IF 4,259)

Hadebe S, Kirstein F, Fierens K, Redelinghuys P, Murray GI, Williams DL, Lambrecht BN, Brombacher F, Brown GD. 2016. β-Glucan exacerbates allergic airway responses to house dust mite allergen. Respir Res. 17:35. (2016 IF 3.841)

Thawer S, Auret J, Schnoeller C, Chetty A, Smith K, Darby M, Roberts L, Mackay RM, Whitwell HJ, Timms JF, Madsen J, Selkirk ME, Brombacher F, Clark HW, Horsnell WG. 2016. Surfactant Protein-D Is Essential for Immunity to Helminth Infection. PLoS Pathog. 12:e1005461. (2015 IF 7)

Piehler D, Eschke M, Schulze B, Protschka M, Müller U, Grahnert A, Richter T, Heyen L, Köhler G, Brombacher F, Alber G. 2016. The IL-33 receptor (ST2) regulates early IL-13 production in fungus-induced allergic airway inflammation. Mucosal Immunol. 9:937-49. . (2016 IF 6.608)

Hoving JC, Nieuwenhuizen NE, Schäfer G, Katz AA, Brombacher F. 2016. IL-13 signals independent of IL-4 receptor-alpha chain to drive ovalbumin-induced dermatitis. J Invest Dermatol. 136:1286-90. (2015 IF 6.287)

Kirstein F, Nieuwenhuizen NE, Jayakumar J, Horsnell WG, Brombacher F. 2016. Role of IL-4 receptor α-positive CD4+ T cells in chronic airway hyperresponsiveness. J Allergy Clin Immunol. 137:1852-62. (2015 IF 12.485)

Guler R, S. Roy, H. Suzuki, F. Brombacher. 2015.Targeting Batf2 for infectious diseases and cancer. Oncotarget, 6:26575-82 (2015 IF 5.168)

Guler  R & Frank Brombacher. Host-directed drug therapy for tuberculosis. 2015. Nature Chemical Biology. 11:1-4 (2015 IF 13)

Hadebe S, Kirstein F, Fierens K, Chen K, Drummond RA, Vautier S, Sajaniemi S, Murray G, Williams DL, Redelinghuys P, Reinhart TA, Fallert Junecko BA, Kolls JK, Lambrecht BN, Brombacher F, Brown GD. 2015. Microbial Ligand Costimulation Drives Neutrophilic Steroid-Refractory Asthma. PLoS One. 10:e0134219. (2015 IF 3.5)

Roy S, Schmeier S, Arner E, Alam T, Parihar SP, Ozturk M, Tamgue O, Kawaji H, de Hoon MJ, Itoh M, Lassmann T, Carninci P, Hayashizaki Y, Forrest AR, Bajic VB, Guler R, Consortium F, Brombacher F*, Suzuki H. * 2015. Redefining the transcriptional regulatory dynamics of classically and alternatively activated macrophages by deepCAGE transcriptomics. Nucleic Acids Res. 18:6969-82 * corresponding author (2015 IF 9.2)

Cnops, J., C De Trez, B Stijlemans, J Keirsse, F Kauffmann, M Barkhuizen, R Keathon, L Boon, F Brombacher*, St Magez*, 2015 NK-, NKT- and CD8-derived IFNγ drives myeloid cell activation and erythrophagocytosis, resulting in Trypanosomosis-associated acute anemia. PLOSpathogen 12:e1004964* corresponding author (2015 IF 7.4)

Roy S, Guler R, Parihar SP, Schmeier S, Kaczkowski B, Nishimura H, Shin JW, Negishi Y, Ozturk M, Hurdayal R, Kubosaki A, Kimura Y, de Hoon MJ, Hayashizaki Y, Brombacher F*, Suzuki H*. 2015. Batf2/Irf1 Induces Inflammatory Responses in Classically Activated Macrophages, Lipopolysaccharides, and Mycobacterial Infection J Immunol194:6035-44

*corresponding author (2015 IF 5.2)

Guler R, Parihar SP, Savvi S, Logan E, Schwegmann A, Roy S, Nieuwenhuizen NE, Ozturk M, Schmeier S, Suzuki H, Brombacher F. 2015. IL-4Rα-Dependent Alternative Activation of Macrophages Is Not Decisive for Mycobacterium tuberculosis Pathology and Bacterial Burden in Mice. PLoS One. 10:e0121070. (2015 IF 3.5)

Arner E, Daub CO, Vitting-Seerup K, Andersson R, Lilje B, Drabløs F, Lennartsson A, Rönnerblad M, Hrydziuszko O, Vitezic M, Freeman TC, Alhendi AM, Arner P, Axton R, Baillie JK, Beckhouse A, Bodega B, Briggs J, Brombacher F, Davis M, Detmar M, Ehrlund A, Endoh M, Eslami A, Fagiolini M, Fairbairn L, Faulkner GJ, Ferrai C, Fisher ME, Forrester L, Goldowitz D, Guler R, Ha T, Hara M, Herlyn M, Ikawa T, Kai C, Kawamoto H, Khachigian LM, Klinken SP, Kojima S, Koseki H, Klein S, Mejhert N, Miyaguchi K, Mizuno Y, Morimoto M, Morris KJ, Mummery C, Nakachi Y, Ogishima S, Okada-Hatakeyama M, Okazaki Y, Orlando V, Ovchinnikov D, Passier R, Patrikakis M, Pombo A, Qin XY, Roy S, Sato H, Savvi S, Saxena A, Schwegmann A, Sugiyama D, Swoboda R, Tanaka H, Tomoiu A, Winteringham LN, Wolvetang E, Yanagi-Mizuochi C, Yoneda M, Zabierowski S, Zhang P, Abugessaisa I, Bertin N, Diehl AD, Fukuda S, Furuno M, Harshbarger J, Hasegawa A, Hori F, Ishikawa-Kato S, Ishizu Y, Itoh M, Kawashima T, Kojima M, Kondo N, Lizio M, Meehan TF, Mungall CJ, Murata M, Nishiyori-Sueki H, Sahin S, Nagao-Sato S, Severin J, de Hoon MJ, Kawai J, Kasukawa T, Lassmann T, Suzuki H, Kawaji H, Summers KM, Wells C; FANTOM Consortium, Hume DA, Forrest AR, Sandelin A, Carninci P, Hayashizaki Y. 2015.  Transcribed enhancers lead waves of coordinated transcription in transitioning mammalian cells. Science. 347:1010-4. . (2014 IF 33.6)

Darby M, Schnoeller C, Vira A, Culley F, Bobat S, Logan E, Kirstein F, Wess J, Cunningham AF, Brombacher F, Selkirk ME, Horsnell WG. 2015. The M3 muscarinic receptor is required for optimal adaptive immunity to helminth and bacterial infection. PLoS Pathog. 11:e1004636. (2015 IF 7.4)

Chen C, Akiyama K, Wang D, Xu X, Li B, Moshaverinia A, Brombacher F, Sun L, Shi S. 2015. mTOR inhibition rescues osteopenia in mice with systemic sclerosis. J Exp Med. 212:73-91. (2015 IF 11.7)

Bobat S, Darby M, Mrdjen D, Cook C, Logan E, Auret J, Jones E, Schnoeller C, Flores-Langarica A, Ross EA, Vira A, López-Macías C, Henderson IR, Alexander J, Brombacher F, Horsnell WG, Cunningham AF. 2014. Natural and vaccine-mediated immunity to Salmonella Typhimurium is impaired by the helminth Nippostrongylus brasiliensis. PLoS Negl Trop Dis. 8:e3341. (2014 IF 5.7)

Heitmann L, Abad Dar M, Schreiber T, Erdmann H, Behrends J, Mckenzie AN, Brombacher F, Ehlers S, Hölscher C. 2014. The IL-13/IL-4Rα axis is involved in tuberculosis-associated pathology. J Pathology. 234:338-50 . (2014 IF 7.3)

Ndlovu, H., M. Darby, M. Froelich, W. Horsnell, F. Lühder T. Hünig and Frank Brombacher. 2014. CD28 costimulation is required for T follicular helper cell expansion and type-2 mediated N. brasiliensis immunity during secondary infection. PLOSpathogen 10:e1003906. (2014 IF 9.8)

Grahnert A, Richter T, Piehler D, Eschke M, Schulze B, Müller U, Protschka M, Köhler G, Sabat R, Brombacher F, Alber G. 2014. IL-4 Receptor-Alpha-Dependent Control of Cryptococcus neoformans in the Early Phase of Pulmonary Infection. PLoS One. 9:e87341. (2014 IF 3.2)

FANTOM Consortium and the RIKEN PMI and CLST (DGT), Forrest AR, Kawaji H, Rehli M, Baillie JK, de Hoon MJ, Haberle V, Lassmann T, Kulakovskiy IV, Lizio M, Itoh M, Andersson R, Mungall CJ, Meehan TF, Schmeier S, Bertin N, Jørgensen M, Dimont E, Arner E, Schmidl C, Schaefer U, Medvedeva YA, Plessy C, Vitezic M, Severin J, Semple C, Ishizu Y, Young RS, Francescatto M, Alam I, Albanese D, Altschuler GM, Arakawa T, Archer JA, Arner P, Babina M, Rennie S, Balwierz PJ, Beckhouse AG, Pradhan-Bhatt S, Blake JA, Blumenthal A, Bodega B, Bonetti A, Briggs J, Brombacher F, Burroughs AM, Califano A, Cannistraci CV, Carbajo D, Chen Y, Chierici M, Ciani Y, Clevers HC, Dalla E, Davis CA, Detmar M, Diehl AD, Dohi T, Drabløs F, Edge AS, Edinger M, Ekwall K, Endoh M, Enomoto H, Fagiolini M, Fairbairn L, Fang H, Farach-Carson MC, Faulkner GJ, Favorov AV, Fisher ME, Frith MC, Fujita R, Fukuda S, Furlanello C, Furino M, Furusawa J, Geijtenbeek TB, Gibson AP, Gingeras T, Goldowitz D, Gough J, Guhl S, Guler R, Gustincich S, Ha TJ, Hamaguchi M, Hara M, Harbers M, Harshbarger J, Hasegawa A, Hasegawa Y, Hashimoto T, Herlyn M, Hitchens KJ, Ho Sui SJ, Hofmann OM, Hoof I, Hori F, Huminiecki L, Iida K, Ikawa T, Jankovic BR, Jia H, Joshi A, Jurman G, Kaczkowski B, Kai C, Kaida K, Kaiho A, Kajiyama K, Kanamori-Katayama M, Kasianov AS, Kasukawa T, Katayama S, Kato S, Kawaguchi S, Kawamoto H, Kawamura YI, Kawashima T, Kempfle JS, Kenna TJ, Kere J, Khachigian LM, Kitamura T, Klinken SP, Knox AJ, Kojima M, Kojima S, Kondo N, Koseki H, Koyasu S, Krampitz S, Kubosaki A, Kwon AT, Laros JF, Lee W, Lennartsson A, Li K, Lilje B, Lipovich L, Mackay-Sim A, Manabe R, Mar JC, Marchand B, Mathelier A, Mejhert N, Meynert A, Mizuno Y, de Lima Morais DA, Morikawa H, Morimoto M, Moro K, Motakis E, Motohashi H, Mummery CL, Murata M, Nagao-Sato S, Nakachi Y, Nakahara F, Nakamura T, Nakamura Y, Nakazato K, van Nimwegen E, Ninomiya N, Nishiyori H, Noma S, Noma S, Noazaki T, Ogishima S, Ohkura N, Ohimiya H, Ohno H, Ohshima M, Okada-Hatakeyama M, Okazaki Y, Orlando V, Ovchinnikov DA, Pain A, Passier R, Patrikakis M, Persson H, Piazza S, Prendergast JG, Rackham OJ, Ramilowski JA, Rashid M, Ravasi T, Rizzu P, Roncador M, Roy S, Rye MB, Saijyo E, Sajantila A, Saka A, Sakaguchi S, Sakai M, Sato H, Savvi S, Saxena A, Schneider C, Schultes EA, Schulze-Tanzil GG, Schwegmann A, Sengstag T, Sheng G, Shimoji H, Shimoni Y, Shin JW, Simon C, Sugiyama D, Sugiyama T, Suzuki M, Suzuki N, Swoboda RK, ‘t Hoen PA, Tagami M, Takahashi N, Takai J, Tanaka H, Tatsukawa H, Tatum Z, Thompson M, Toyodo H, Toyoda T, Valen E, van de Wetering M, van den Berg LM, Verado R, Vijayan D, Vorontsov IE, Wasserman WW, Watanabe S, Wells CA, Winteringham LN, Wolvetang E, Wood EJ, Yamaguchi Y, Yamamoto M, Yoneda M, Yonekura Y, Yoshida S, Zabierowski SE, Zhang PG, Zhao X, Zucchelli S, Summers KM, Suzuki H, Daub CO, Kawai J, Heutink P, Hide W, Freeman TC, Lenhard B, Bajic VB, Taylor MS, Makeev VJ, Sandelin A, Hume DA, Carninci P, Hayashizaki Y. 2014. A promoter-level mammalian expression atlas. Nature. 2015-70. (2014 IF 41.4)

Imanishi T, Ishihara C, Badr Mel S, Hashimoto-Tane A, Kimura Y, Kawai T, Takeuchi O, Ishii KJ, Taniguchi S, Noda T, Hirano H, Brombacher F, Barber GN, Akira S, Saito T. 2014. Nucleic acid sensing by T cells initiates Th2 cell differentiation. Nat Commun 5:3566. (2014 IF 11.4)

Hurdayal R, Brombacher F. 2014. The role of IL-4 and IL-13 in cutaneous Leishmaniasis. Immunol Lett. 9:e87341 (2014 IF 2.5)

Thawer SG, Horsnell WG, Darby M, Hoving JC, Dewals B, Cutler AJ, Lang D, Brombacher F. 2014. Lung-resident CD4+ T cells are sufficient for IL-4Rα-dependent recall immunity to Nippostrongylus brasiliensis infection. Mucosal Immunol. 2:239-48 (2014 IF 7.3]

Parihar, S. Reto Guler, Dirk M. Lang, Rethabile Khutlang, Musa M. Mhlanga, Harukazu Suzuki, A. David Marais and Frank Brombacher. 2014. Statins mediate protection against Mycobacterium tuberculosis infection by enhancing phagosomal maturation and autophagy. J. Inf. Dis. 209:754-63 (5.8)

Hurdayal, R., N.E. Nieuwenhuizen, M. Revaz-Breton, L. Smith1, J.C. Hoving, S.P. Parihar, B.Reizis and F.Brombacher. 2013. Deletion of IL-4 receptor alpha on dendritic cells renders BALB/c mice hypersusceptible to Leishmania major infection. PLOSpathogen 9:e1003699 (IF 9.6)

Horsnell, WGC, M Darby, JC Hoving, N Nieuwenhuizen, S Bobat, H Ndlovu, M Kimberg, F Brombacher. 2013. Rapid 4R<alpha> associated antigen processing by B cells promotes recall immunity in Nippostrongylus brasiliensis infection. 2013. PLOSpathogen 9:e1003662 (IF 9.6)

Ndlovu H, Brombacher F. 2013. Role of IL-4Rα during acute schistosomiasis in mice. Parasite Immunol. Oct 15. doi: 10.1111/pim.12080. (IF 2.2)

Jenkins SJ, Ruckerl D, Thomas GD, Hewitson JP, Duncan S, Brombacher F, Maizels RM, Hume DA, Allen JE. 2013. IL-4 directly signals tissue-resident macrophages to proliferate beyond homeostatic levels controlled by CSF-1. J Exp Med. 2013, 210:2477-91 (IF 15.1).

Parihar,S., Reto Guler, Harukazu Suzuki, A. David Marais and Frank Brombacher. 2013. Statins enhance protection against Listeria monocytogenes infection in mice by counteracting Listeria-induced phagosomal escape. PLOSONE, 24:e75490. (IF 4.4)

Nieuwenhuizen NE, Meter JM, Horsnell WG, Hoving JC, Fick L, Sharp MF, Darby MG, Parihar SP, Brombacher F, Lopata AL. 2013. A Cross-Reactive Monoclonal Antibody to Nematode Haemoglobin Enhances Protective Immune Responses to Nippostrongylus brasiliensis. PLoS Negl Trop 7:e2395. .(IF 4.7)

Wermeling F, Anthony RM, Brombacher F, Ravetch JV. 2013. Acute inflammation primes myeloid effector cells for anti-inflammatory STAT6 signaling. Proc Natl Acad Sci U S A. 110:13487-91. . (I.F.= 10.4)

Davies LC, Rosas M, Jenkins SJ, Liao CT, Scurr MJ, Brombacher F, Fraser DJ, Allen JE, Distinct bone marrow-derived and tissue-resident macrophage lineages proliferate at key stages during inflammation. Nat Commun. 2013. 4:1886 (IF 10)

You D, Marr N, Saravia J, Shrestha B, Lee GI, Turvey SE, Brombacher F, Herbert D, Cormier SA. 2013. IL-4Rα on CD4+ T cells plays a pathogenic role in respiratory syncytial virus reinfection in mice infected initially as neonates. J Leukoc Biol. 93:933-42. (I.F. = 4.5)

Müller U, Stenzel W, Piehler D, Grahnert A, Protschka M, Köhler G, Frey O, Held J, Richter T, Eschke M, Kamradt T, Brombacher F, Alber G. 2013. Abrogation of IL-4 receptor-α-dependent alternatively activated macrophages is sufficient to confer resistance against pulmonary cryptococcosis despite an ongoing Th2 response. Int Immunol. 25:459-70 (IF 3.3)

Zeng MY, Pham D, Bagaitkar J, Liu J, Otero K, Shan M, Wynn TA, Brombacher F, Brutkiewicz RR, Kaplan MH, Dinauer MC. 2013. An efferocytosis-induced, IL-4-dependent macrophage-iNKT cell circuit suppresses sterile inflammation and is defective in murine CGD. Blood. 121:13487-93 (IF 11)

du Plessis N, Kleynhans L, Thiart L, van Helden PD, Brombacher F, Horsnell WG, Walzl G. 2013. Acute helminth infection enhances early macrophage mediated control of mycobacterial infection. Mucosal Immunol. 6:931-41. (IF 6.8)

Schmidt S, Hoving JC, Horsnell WG, Mearns H, Cutler AJ, Brombacher TM, Brombacher F. 2012. Nippostrongylus-Induced Intestinal Hypercontractility Requires IL-4 Receptor Alpha-Responsiveness by T Cells in Mice. PLoS One. 7(12):e52211.  (IF 4.4)

Gogishvili T, Lühder F, Kirstein F, Nieuwenhuizen NE, Goebbels S, Beer-Hammer S, Pfeffer K, Reuter S, Taube C, Brombacher F, Hünig T. 2012. Interruption of CD28-mediated costimulation during allergen challenge protects mice from allergic airway disease. J Allergy Clin Immunol. 6749:1504-7. (IF 9.7)

Masic A, Hurdayal R, Nieuwenhuizen NE, Brombacher F, Moll H. 2012. Dendritic Cell-Mediated Vaccination Relies on Interleukin-4 Receptor Signaling to Avoid Tissue Damage after Leishmania major Infection of BALB/c Mice. PLoS Negl Trop Dis. 6:e1721.(IF 4.7)

Komai-Koma M, Brombacher F, Pushparaj PN, Arendse B, McSharry C, Alexander J, Chaudhuri R, Thomson NC, McKenzie AN, McInnes I, Liew FY, Xu D. 2012. Interleukin-33 amplifies IgE synthesis and triggers mast cell degranulation via interleukin-4 in naïve mice. Allergy. 67:1118-26 (IF 6.3, 2015 citation = 56)

Alexander J, Brombacher F. 2012. T helper1/T helper2 cells and resistance/susceptibility to leishmania infection: is this paradigm still relevant? Front Immunol. 2012; 3:80.

Link A, Zabel F, Schnetzler Y, Titz A, Brombacher F, Bachmann MF. 2012. Innate Immunity Mediates Follicular Transport of Particulate but Not Soluble Protein Antigen. J Immunol. 188:3724-33. (IF 5.7, 12.2015 citation = 52 )

Nieuwenhuizen NE, Kirstein F, Jayakumar J, Emedi B, Hurdayal R, Horsnell W, Brombacher F 2012. Allergic airway disease is unaffected by the absence of IL-4Ra-dependent alternatively activated macrophages. J Allergy Clin Immunol, 130:743-50 (IF 9.7)

Müller U, Piehler D, Stenzel W, Köhler G, Frey O, Held J, Grahnert A, Richter T, Eschke M, Kamradt T, Brombacher F, Alber G. 2012. Lack of IL-4 receptor expression on T helper cells reduces T helper 2 cell polyfunctionality and confers resistance in allergic bronchopulmonary mycosis. Mucosal Immunol.5:255-310 (IF 6.8)

Strasser D, Neumann K, Bergmann H, Marakalala MJ, Guler R, Rojowska A, Hopfner KP, Brombacher F, Urlaub H, Baier G, Brown GD, Leitges M, Ruland J. 2012 Syk Kinase-Coupled C-type Lectin Receptors Engage Protein Kinase C-δ to Elicit Card9 Adaptor-Mediated Innate Immunity. Immunity. 36:32-42. (IF 24)

Hoving, JC, F. Kirstein, N. Nieuwenhuizen, E. Hobeika, M. Reth and F. Brombacher 2012. Immunoglobulin E-producing B lymphocytes mediate colitis in BALB/c mice. Gastroenterology, 142:96-108. (IF 12). (1121.4).

Nguyen, K.D., Y. Qiu, X. Cui, Y.P. S. Goh, J. Mwangi, T. David, L. Mukundan, F. Brombacher, R.M. Locksley, A. Chawla. 2011. Alternatively activated macrophages produce catecholamines to sustain adaptive thermogenesis. Nature 480:104-8. (IF 27, citation 12.2015 = 288)

McFarlane, E., Carter, K.C., McKenzie, A., Kaye, P.M., Brombacher, F., and Alexander, J., 2011. Endogenous IL-13 plays a crucial role in liver granuloma maturation during Leishmania donovani infection via a macrophage independent mechanism. Journal of Infectious Diseases204:36-43 (IF 5.2)

Perkins, C., Yanase, N., Smulian, G., Gildea, L., Orekov, T., Potter, C., Brombacher, F., Wills-Karp, M., and Finkelman, F. D. 2011. Selective stimulation of IL-4 receptor on smooth muscle induces airway hyperresponsiveness in mice. J Exp Med. 208:853-67 (IF 15.1).

Cook PC, Aynsley SA, Turner JD, Jenkins GR, Van Rooijen N, Leeto M, Brombacher F, Mountford AP. 2011. Multiple helminth infection of the skin causes lymphocyte hypo-responsiveness mediated by th2 conditioning of dermal myeloid cells. PLoS Pathog. Mar; 7:e1001323. (IF 9.6)

Guler R, Afshar M, Arendse B, Parihar SP, Revaz-Breton M, Leitges M, Schwegmann A, Brombacher F. 2011. PKCδ regulates IL-12p40/p70 production by macrophages and dendritic cells, driving a type 1 healer phenotype in cutaneous leishmaniasis. Eur J Immunol. 41:706-15. (IF 6)

Bryson KJ, Millington OR, Mokgethi T, McGachy HA, Brombacher F, Alexander. 2011. BALB/c Mice Deficient in CD4 T Cell IL-4Rα Expression Control Leishmania mexicana Load although Female but Not Male Mice Develop a Healer Phenotype. J. PLoS Negl Trop Dis. Jan4; 5:e930.(IF 4.7)

Van der Ventel, M.L., N.E. Nieuwenhuizen, F. Kirstein1, C. Hikuam,  M.F. Jeebhay, I. Swoboda, F. Brombacher*, and A.L. Lopata. 2011. Differential responses to natural and recombinant allergens 1 in a murine model of fish allergy. Mol Immunol. 48:637-46.

corresponding author (IF 3)

Guler R, Parihar SP, Spohn G, Johansen P, Brombacher F* Bachmann MF. 2011. Blocking IL-1α but not IL-1β increases susceptibility to chronic Mycobacterium tuberculosis infection in mice. Vaccine. 29: 1339–1346. * corresponding author (IF 5)

Marakalala, M.J., R. Guler, L. Matika, G. Murray, M. Jacobs, F. Brombacher, A. Gigliotti Rothfuchs, A. Sher and G.D. Brown. 2011. The Syk/ CARD9‑coupled receptor Dectin‑1 is not required for host resistance to Mycobacterium tuberculosis in mice. Microbes & Infection 13: 198-201. (IF 2.8)

Horsnell WG, Vira A, Kirstein F, Mearns H, Hoving JC, Cutler AJ, Dewals B, Myburgh E, Kimberg M, Arendse B, White N, Lopata A, Burger PE, Brombacher F. 2011.. IL-4Ralpha-responsive smooth muscle cells contribute to initiation of T(H)2 immunity and pulmonary pathology in Nippostrongylus brasiliensis infections. Mucosal Immunol. 4:83-92 (IF 6.8)

Dewals B, Hoving JC, Horsnell WG, Brombacher F. 2010. Control of Schistosoma mansoni egg-induced inflammation by IL-4-responsive CD4(+)CD25(-)CD103(+)Foxp3(-) cells is IL-10-dependent. Eur J Immunol. 40:2837-47 (IF 6)

Kirstein F, Horsnell WG, Nieuwenhuizen N, Ryffel B, Lopata AL, Brombacher F., (2010). Anisakis-induced airway hyperresponsiveness is mediated by IFN-{gamma} in the absence of IL-4R{alpha}-responsiveness. Infect Immun.  78:4077-86 (IF 3.7).

Horsnell WG, Brombacher F. (2010). Genes associated with alternatively activated macrophages discretely regulate helminth infection and pathogenesis in experimental mouse models. Immunobiology. 215:704-.8 (IF 3.6)

Kirstein F, Horsnell WG, Kuperman DA, Huang X, Erle DJ, Lopata AL, Brombacher F. (2010). Expression of IL-4 receptor alpha on smooth muscle cells is not necessary for development of experimental allergic asthma. J Allergy Clin Immunol. 126:347-54. (IF 9)

Uyttenhove C, Brombacher F, Van Snick J. (2010). TGF-beta interactions with IL-1 family members trigger IL-4-independent IL-9 production in mouse CD4 T cells. Eur J Immunol.Aug;40(8):2230-5 (IF 6) (1061.3)

Dewals BG, Marillier RG, Hoving JC, Leeto M, Schwegmann A, Brombacher F. (2010). IL-4Ralpha-independent expression of mannose receptor and Ym1 by macrophages depends on their IL-10 responsiveness. PLoS Negl Trop Dis.May 18;4(5):e689 (IF 4.1)

Hünig T, Lühder F, Elflein K, Gogishvili T, Fröhlich M, Guler R, Cutler A, Brombacher F. (2010). CD28 and IL-4: two heavyweights controlling the balance between immunity and inflammation. Med Microbiol Immunol. 199:239-46 (IF 2)

Marillier RG, Brombacher TM, Dewals B, Leeto M, Barkhuizen M, Govender D, Kellaway L, Horsnell WG, Brombacher, F. (2010). IL-4R{alpha}-responsive smooth muscle cells increase intestinal hypercontractility and contribute to resistance during acute Schistosomiasis. Am J Physiol Gastrointest Liver Physiol. 298: 943-951. (IF 4.7)

Jones, LA, Roberts F, Nickdel MB, Brombacher F, McKenzie AN, Henriquez FL, Alexander J, Roberts CW. (2010). IL-33 receptor (T1/ST2) signalling is necessary to prevent the development of encephalitis in mice infected with Toxoplasma gondii. Eur J Immunol. 40:426-26 (IF 6).

Michels CE, Scales HE, Saunders KA, McGowan S, Brombracher F, Alexander J, Lawrence CE. (2009). Neither interleukin-4 receptor alpha expression on CD4+ T cells, or macrophages and neutrophils is required for protective immunity to Trichinella spiralis. Immunology. 128: e385-94. (IF 3.6).

Schäfer G, Guler R, Murray G, Brombacher F, Brown GD.(2009).The role of scavenger receptor B1 in infection with Mycobacterium tuberculosis in a murine model. PLoS One. Dec 24; 4(12):e8448 (IF 4.3).

Herbert DR, Yang JQ, Hogan SP, Groschwitz K, Khodoun M, Munitz A, Orekov T, Perkins C, Wang Q, Brombacher F, Urban JF Jr, Rothenberg ME, Finkelman FD. (2009). Intestinal epithelial cell secretion of RELM-{beta} protects against gastrointestinal worm infection. J Exp Med. 21:206:2947-57 (IF 15.1). 1001

Dewals, B., J. C. Hoving, M. Leeto, R. G. Marillier, U. Govender, A. J. Cutler, W. G.C. Horsnell, F. Brombacher. (2009). IL-4Ra responsiveness of non-CD4 T cells contributes to resistance in Schistosoma mansoni infection investigated in pan-T cell-specific IL-4Rα-deficient mice. The Journal of American Pathology. 175:706-16 (IF 5.5).

Keating P, O’Sullivan D, Tierney JB, Kenwright D, Miromoeini S, Mawasse L, Brombacher F, La Flamme AC. (2009). Protection from EAE by IL-4Ralpha(-/-) macrophages depends upon T regulatory cell involvement. Immunol Cell Biol. Oct; 87(7):534-45. (IF 3)

FANTOM Consortium, Suzuki H, Forrest AR, van Nimwegen E, Daub CO, Balwierz PJ, Irvine KM, Lassmann T, Ravasi T, Hasegawa Y, de Hoon MJ, Katayama S, Schroder K, Carninci P, Tomaru Y, Kanamori-Katayama M, Kubosaki A, Akalin A, Ando Y, Arner E, Asada M, Asahara H, Bailey T, Bajic VB, Bauer D, Beckhouse AG, Bertin N, Björkegren J, Brombacher F, Bulger E, Chalk AM, Chiba J, Cloonan N, Dawe A, Dostie J, Engström PG, Essack M, Faulkner GJ, Fink JL, Fredman D, Fujimori K, Furuno M, Gojobori T, Gough J, Grimmond SM, Gustafsson M, Hashimoto M, Hashimoto T, Hatakeyama M, Heinzel S, Hide W, Hofmann O, Hörnquist M, Huminiecki L, Ikeo K, Imamoto N, Inoue S, Inoue Y, Ishihara R, Iwayanagi T, Jacobsen A, Kaur M, Kawaji H, Kerr MC, Kimura R, Kimura S, Kimura Y, Kitano H, Koga H, Kojima T, Kondo S, Konno T, Krogh A, Kruger A, Kumar A, Lenhard B, Lennartsson A, Lindow M, Lizio M, Macpherson C, Maeda N, Maher CA, Maqungo M, Mar J, Matigian NA, Matsuda H, Mattick JS, Meier S, Miyamoto S, Miyamoto-Sato E, Nakabayashi K, Nakachi Y, Nakano M, Nygaard S, Okayama T, Okazaki Y, Okuda-Yabukami H, Orlando V, Otomo J, Pachkov M, Petrovsky N, Plessy C, Quackenbush J, Radovanovic A, Rehli M, Saito R, Sandelin A, Schmeier S, Schönbach C, Schwartz AS, Semple CA, Sera M, Severin J, Shirahige K, Simons C, St Laurent G, Suzuki M, Suzuki T, Sweet MJ, Taft RJ, Takeda S, Takenaka Y, Tan K, Taylor MS, Teasdale RD, Tegnér J, Teichmann S, Valen E, Wahlestedt C, Waki K, Waterhouse A, Wells CA, Winther O, Wu L, Yamaguchi K, Yanagawa H, Yasuda J, Zavolan M, Hume DA; Riken Omics Science Center, Arakawa T, Fukuda S, Imamura K, Kai C, Kaiho A, Kawashima T, Kawazu C, Kitazume Y, Kojima M, Miura H, Murakami K, Murata M, Ninomiya N, Nishiyori H, Noma S, Ogawa C, Sano T, Simon C, Tagami M, Takahashi Y, Kawai J, Hayashizaki Y. (2009). The transcriptional network that controls growth arrest and differentiation in a human myeloid leukemia cell line. Nature Genetics 41:553-62 (IF 22, citation 2.2015 = 263)

Brombacher F, Arendse B, Peterson R, Hölscher A, Hölscher C. (2009). Analyzing classical and alternative macrophage activation in macrophage/neutrophil-specific IL-4 receptor-alpha-deficient mice. Methods Mol Biol. 2009;531:225-52 (IF 4)

Steenwinckel V, Louahed J, Lemaire MM, Sommereyns C, Warnier G, McKenzie A, Brombacher F, Van Snick J, Renauld JC. (2009). IL-9 promotes IL-13-dependent paneth cell hyperplasia and up-regulation of innate immunity mediators in intestinal mucosa. J Immunol. 182:4737-43 (IF 7.4, 12.2015 citation = 57).

Nieuwenhuizen N, Herbert DR, Brombacher F, Lopata AL. (2009) Differential requirements for interleukin (IL)-4 and IL-13 in protein contact dermatitis induced by Anisakis. Allergy. 64:1309-18 (IF 4)

Stenzel W, Müller U, Köhler G, Heppner FL, Blessing M, McKenzie AN, Brombacher F, Alber G. (2009) IL-4/IL-13-dependent alternative activation of macrophages but not microglial cells is associated with uncontrolled cerebral cryptococcosis. Am J Pathol. 174:486-96 (IF 5.5, 12.2015 citation =55).

Muller, U. W. Stenzel, G. Koehler, T. Polte, M. Blessing, A. Mann, D. Piehler, F. Brombacher, G. Alber. (2008). A gene-dosage effect for interleukin-4 receptor alpha-chain expression has an impact on Th2-mediated allergic inflammation during bronchopulmonary mycosis. J. Infect. Dis 198:1714-21. (IF 5.5)

Horsnell, W.G., F. Brombacher. (2008) Key roles for specific and nonspecific antibody in intestinal nematode expulsion. Cell Host Microbe 16:303-5 (IF 13.5)

Barkhuizen, M., S Magez, B Ryffel and F Brombacher. (2008). Interleukin-12p70 Deficiency Increases Survival and Diminishes Pathology in Trypanosoma congolense Infection. J. Infect. Dis 198:1284-91. (IF 5.5)

Mearns H, W GC Horsnell, J C Hoving, B. Dewals, A. J. Cutler, F. Kirstein, E Myburgh, B. Arendse and F. Brombacher. (2008). IL-4 promoted T-helper 2 responses enhance Nippostrongylus brasiliensis induced pulmonary pathology. Infect. & Immunity, 76:5535-42 (IF 3.7).

Barbi, J, F. Brombacher, AR Satoskar. (2008). T cells from Leishmania major-susceptible BALB/c mice have a defect in efficiently up-regulating CXCR3 upon activation. J. Immunol. 181:4613-20 (IF 7.4).

Magez, S., A. Schwegmann, R. Atkinson, F. Claes, M. Drennan,P. De Baetselier, and F. Brombacher. (2008). The role of B-cells and IgM antibodies in parasitemia, anemia, and VSG switching in Trypanosoma brucei-infected mice. PLoSpathogen, 4:e1000122 (IF 9.6).

Schwegmann, A & F. Brombacher. (2008). Host-directed drug targeting of factors hijacked by pathogens. Science Signaling 1:29-36.

Marillier, R. G., C. Michels, E M Smith, L Fick, M Leeto, B Dewals, W GC Horsnell, F Brombacher. (2008).IL-4/IL-13 independent goblet cell hyperplasia in experimental helminth infections. BMC Immunology. 9:11-18. (IF 3)

Myburgh E, Horsnell WG, Cutler AJ, Arendse B, Kubo M, Brombacher F. (2008). Murine IL-4 is able to signal via chimeric human IL-4Ralpha/mouse gamma-chain receptor. Mol Immunol. 45:1327-36. (IF 4)

Barkhuizen, M, S. Magez, R.A. Atkinson, & F. Brombacher. (2007). Interleukin 12p70-dependendent IFN-g production is crucial for resistance in African Trypanosomiasis. J Infect Dis. 1196:1253-60 (IF 5.5) 887.9

Schwegmann A, Guler R, Cutler AJ, Arendse B, Horsnell WG, Flemming A, Kottmann AH, Ryan G, Hide W, Leitges M, Seoighe C, Brombacher F. (2007). Protein kinase C {delta} is essential for optimal macrophage-mediated phagosomal containment of Listeria monocytogenes. Proc Natl Acad Sci U S A. 104:16251-6. (I.F.= 10.4)

Muller U, Stenzel W, Kohler G, Werner C, Polte T, Hansen G, Schutze N, Straubinger RK, Blessing M, McKenzie AN, Brombacher F, Alber G. (2007). IL-13 Induces Disease-Promoting Type 2 Cytokines, Alternatively Activated Macrophages and Allergic Inflammation during Pulmonary Infection of Mice with Cryptococcus neoformans. J Immunol. 179(8):5367-77 (I.F. = 7.4,2.2012 citation = 56).

Loke P, Gallagher I, Nair MG, Zang X, Brombacher F, Mohrs M, Allison JP, Allen JE. (2007). Alternative activation is an innate response to injury that requires CD4+ T cells to be sustained during chronic infection. J Immunol. 179(6):3926-36 (IF 7.4, 2.2012 citation = 68).

N. Nieuwenhuizen, D. R. Herbert, A. L. Lopata, F. Brombacher (2007). CD4+ T Cell-Specific Deletion of IL-4 Receptor {alpha} Prevents Ovalbumin-Induced Anaphylaxis by an IFN-{gamma}-Dependent Mechanism. J. Immunol. 179: 2758-65 (IF 7.4).

S. Magez, M. Radwanska, M. Drennan, L. Fick, T.N. Baral, N. Allie, M. Jacobs, S. Nedospasov, F. Brombacher, B. Ryffel, P.D. Baetsellier (2007). Tumor Necrosis Factor (TNF) Receptor-1 (TNFp55) Signal Transduction and Macrophage-Derived Soluble TNF Are Crucial for Nitric Oxide-Mediated Trypanosoma congolense Parasite Killing. J. Infect. Dis. 196:954-62 (IF 5.5).

Odegaard, J.I., R.E. Ricardo-Gonzalez, M.H. Goforth, C.R. Morel, V. Subramanian, L. Mukundan, A. Red Eagle, D. Vats, F. Brombacher A.W. Ferrante, A. Chawla. (2007). Macrophage-specific PPARg controls alternative activation and improves insulin resistance. Nature 447:1116-20 (IF 27 2.2015 citation = 1105).

Spohn, G., R. Guler, P. Johansen, I. Keller, M. Jacobs, M. Beck, F. Rohner, M. Bauer, K. Dietmeier, T.M. Kündig, G.T. Jennings, F. Brombacher, and M.F. Bachmann (2007) A VLP-based Vaccine against Soluble TNFa Protects from Arthritis without Inducing Reactivation of Tuberculosis. J. Immunol. 178:7450-57 (IF 7.4).

Radwanska M, Cutler AJ, Hoving JC, Magez S, Holscher C, Bohms A, Arendse B, Kirsch R, Hunig T, Alexander J, Kaye P, Brombacher F. (2007). Deletion of IL-4Ralpha on CD4 T cell renders BALB/c mice resistant to Leishmania major phenotype. PLoSpathogen,3:e68. (IF 9.6, 12.2015 citation = 50)

Baral, TN, De Baetselier P, Brombacher F, Magez S. (2007). Control of Trypanosoma evansi Infection Is IgM Mediated and Does Not Require a Type I Inflammatory Response. J Infect Dis. 195:1513-20 (IF 5.5).

Baschuk, R., O. Utermoehlen, N. Gugel, G. Warnecke, U. Karow, D. Paulson, F. Brombacher, M. Kroehnke, W. Deppert (2007). Interleukin-4 impairs granzyme-mediated cytotoxicity of Simian virus 40 large tumor antigen-specific CTL in BALB/c mice. Cancer Immunol Immunother. 56:1625-36 (IF approx 3)

Waisman A, Kraus M, Seagal J, Ghosh S, Melamed D, Song J, Sasaki Y, Classen S, Lutz C, Brombacher F, Nitschke L, Rajewsky K. (2007). IgG1 B cell receptor signaling is inhibited by CD22 and promotes the development of B cells whose survival is less dependent on Iga/b. J Exp Med. 4:747-58 (IF 15.1).

Horsnell, W. G. C., A. J. Cutler, C. Hoving, H. Mearns, E. Myburg, B. Arendse, F. D. Finkelman, G. K. Owens, D. Erle, and F. Brombacher (2007). Delayed goblet cell hyperplasia and worm expulsion in smooth muscle cell specific IL-4Ra deficient mice. PLoS pathogen, 162:7302-7308. (IF 9.6)

Cao Y, Brombacher F, Tunyogi-Csapo M, Glant TT, Finnegan A. (2007). Interleukin-4 regulates proteoglycan-induced arthritis by specifically suppressing the innate immune response. Arthritis Rheum. 3:861-70. (IF approx 4)

Kleinschek MA, Owyang AM, Joyce-Shaikh B, Langrish CL, Chen Y, Gorman DM, Blumenschein WM, McClanahan T, Brombacher F, Hurst SD, Kastelein RA, Cua DJ. (2007) IL-25 regulates Th17 function in autoimmune inflammation. J Exp Med. 204:161-70. (IF 15.1, 2.2015 citation = 318).

Schnyder-Candrian S, Togbe D, Couillin I, Mercier I, Brombacher F, Quesniaux V, Fossiez F, Ryffel B, Schnyder B. (2006). Interleukin-17 is a negative regulator of established allergic asthma. J Exp Med. 203:2715-25 (IF 15/.12.2015 citation = 568)

Leeto, M., D. R. Herbert, R. Mariller, A. Schwegmann, L. Fick, and F. Brombacher (2006). TH1-Dominant Granulomatous Pathology Does Not Inhibit Fibrosis or Cause Lethality during Murine Schistosomiasis. J. American Pathology. 169:1701-12. (IF 9)

Gallina G., L. Dolcetti, P. Serafini, C. De Santo, I. Marigo, M.P. Colombo, G. Basso, F. Brombacher, I. Borrello, P. Zanoveilo,  S. Bicciato, V. Bronte (2006). Tumors induce a subset of inflammatory monocytes with immunosuppressive activity on CD8+ T cells. J. Clin. Invest., 116:2777(IF 13, 2.2015 citation = 589) 6,266

Misson P, Brombacher F, Delos M, Lison D, Huaux FA. (2006). Type-2 immune response associated with silicosis is not instrumental in the development of the disease. Am J Physiol Lung Cell Mol Physiol. 292:L107-13 (IF 3)

Michels, C., P. Goyal, N. Nieuwenhuizen and F. Brombacher (2006). Infection with Syphacia obvelata (pinworm) induces protective Th2 immune responses and influences Ovalbumin-induced allergic reactions. Inf. & Immun. 74:5926-32. (IF 3.7).

Balic A, Harcus YM, Taylor MD, Brombacher F, Maizels RM. (2006). IL-4R signaling is required to induce IL-10 for the establishment of Th2 dominance. Int Immunol., 18:1421-31. (IF 4.3)

Nieuwenhuizen, N., A. L. Lopata, M. F. Jeebhay, D. R. Herbert, T. G.Robins, F. Brombacher (2006). The nematode Anisakis, hidden in fish, can cause occupational allergy. J Allergy Clin Immun, 117:1098. (IF 9)

Magez S, Radwanska M, Drennan M, Fick L, Baral TN, Brombacher F, Baetselier PD. (2006). Interferon- gamma and Nitric Oxide in Combination with Antibodies Are Key Protective Host Immune Factors during Trypanosoma congolense Tc13 Infections. J Infect Dis.193:1575-1583. (IF 5.5)

Ghassabeh GH, De Baetselier P, Brys L, Noël W, Van Ginderachter JA, Meerschaut S, Beschin A, Brombacher F, Raes G. (2006). Identification of a common gene signature for type II cytokine-associated myeloid cells elicited in vivo during different pathologies. Blood, 108:575-83. (IF 11; , 2.2012 citation = 66)

Pace, L., S. Rizzo, C. Palombi, F. Brombacher, G. Doria. (2006). IL-4-induced protection of CD4+CD25- Th cells from CD4+CD25+ regulatory T cell-mediated suppression. J. Immunol. 176:3900-04. (IF 7.4, 12.2015 citation =57).

Cutler, A. & F. Brombacher (2005) Cytokine Therapy. Ann NY Acad Sci. 1056:16-29. (IF 1.5)

Hölscher, C., B. Arendse, A. Schwegmann, Elmarie Myburgh & F. Brombacher (2006). Impairment of alternative macrophage activation delays cutaneous leishmaniasis in non-healing BALB/c mice. J. Immunol. 176:1115-21 (IF 7.4 2.2012 citation = 50)

Couper KN, Roberts CW, Brombacher F, Alexander J, Johnson LL. (2005) Toxoplasma gondii-specific immunoglobulin M limits parasite dissemination by preventing host cell invasion. Infect Immun. 73:8060-8. (IF 3.7).

Kuperman, D.A., X. Huang, L. Nguyenvu, C. Hölscher, F. Brombacher & D.J. Erle (2005).IL-4 receptor signaling in Clara cells is required for allergen-induced mucus production. J. Immunol. 175:3746-52 (IF 7.4).

Drennan, M., B. Stijlemans, J. Van Den Abbeele, V. Quesniaux, F. Brombacher, P. De Baetselier, B. Ryffel & S. Magez. (2005). The induction of a type 1 response following a Trypanosoma brucei infection is MyD88-dependent. J. Immunol. 175: p. 2501-2509 (IF 7.4, 2.2012 citation = 60)

Couper KN, RS. Phillips, F. Brombacher, J. Alexander (2005). Parasite-specific IgM plays a significant role in the protective immune response to asexual erythrocytic stage Plasmodium chabaudi AS infection. Parasite Immunol. 27:171-80. (IF ca 1.5).

Brys L, Beschin A, Raes G, Ghassabeh GH, Noël W, Brandt J, Brombacher F, De Baetselier P. (2005). Reactive Oxygen Species and 12/15-lipoxygenase contribute to the anti-proliferative capacity of alternatively activated myeloid cells elicited during helminth infection. J. Immunol., 174:6095-6104. (IF 7.4, 2.2012 citation = 63). 544.6

Arendse, B., Van Snick, J., & Brombacher F. (2005). Interleukin-9 is a susceptibility factor in Leishmania major infection by promoting detrimental Th2/type2 responses. J. Immunol. 174:2205-2211. (IF 7.4).

Arras M, Louahed J, Heilier JF, Delos M, Brombacher F, Renauld JC, Lison D, Huaux F. (2005). IL-9 Protects against Bleomycin-Induced Lung Injury: Involvement of Prostaglandins. Am J Pathol.166(1):107-15. (IF 8)

Raes G, Brys L, Dahal BK, Brandt J, Grooten J, Brombacher F, Vanham G, Noel W, Bogaert P, Boonefaes T, Kindt A, Van den Bergh R, Leenen PJ, De Baetselier P, Ghassabeh GH. (2004). Macrophage galactose-type C-type lectins as novel markers for alternatively activated macrophages elicited by parasitic infections and allergic airway inflammation. J. Leukoc. Biol. 77:321-7. (I.F. = 4.5; , 2.2012 citation = 77)

Uyttenhove C, Arendse B, Stroobant V, Brombacher F, Van Snick J. (2004). Development of an anti-IL-12 p40 auto-vaccine: protection in experimental autoimmune encephalomyelitis at the expense of increased sensitivity to infection. J. Immunol. 34:3572-81. (IF 7.4).

McDonald S.A.C, O’Grady J.E., Bajaj-Elliott M., Notley C.A., Alexander J., Brombacher F. & McDonald V. (2004). IL-4 confers protection against the early acute phase of Cryptosporidium parvum infection by promoting Th1 cytokine expression. J Inf. Dis. 190:1019-25. (IF 5.5).

Nickel, M.B, R. E. Lyons, F. Roberts, F. Brombacher, C. A. Hunter, J. Alexander, C. W. Roberts. 2004. Intestinal pathology during acute toxoplasmosis is IL-4-dependent and unrelated to parasite burden. Parasite Immunol. 26:75-82. (IF 2.6).

Herbert, D. R., C. Hölscher, M. Mohrs, B. Arendse, A. Schwegmann, M. Radwanska, M. Leeto, R. Kirsch,P. Hall, H. Mossmann, B. Claussen, I. Förster & F. Brombacher. 2004. Alternative macrophages activation is essential for survival during schistosomiasis and downmodulates T Helper 1 responses and immunopathology. Immunity. 20:623-35. (IF 20; 12.2015 citation = 481)

Seki, N., M. Miyazaki, W. Suzuki, K. Hayashi, K. Arima, E. Myburgh, K. Izuhara, F. Brombacher, M. Kubo. 2004. Role of IL-4-induced GATA-3 expression as a time-dependent instruction switch on cytokine expression in helper T cell differentiation. J. Immunol., 172:6158-66. (IF 7.4).

Cunningham, A., K. Serre, K-M. Toellner, M. Khan, J. Alexander, F. Brombacher, I.C.M. MacLennan. 2004. Pinpointing IL-4-independent and IL-4-influenced acquisition and maintenance if Th2 activity by CD4 T cells. Europ. J. Immunol. 34:686-94. (IF 6.0, 12.2015 citation = 57)

Han, S., Zhang, X., Finkelman, F.D., Brombacher, F., and Zheng, B. 2004. IgD+IgM- B cells Mount Immune Response that Exhibit Altered Antibody Repertoire. Europ. J. Immunol. 34:661-8. (IF 6.0)

Magez, S., C. Truyens, M. Merimi, M. Radwanska, B. Stijlemans, P. Brouckhaert, F. Brombacher, E. Pays, P.D. Baetselier. 2004. P75 Tumor Necrosis Factor-Receptor Shedding Occurs as a Protective Host Response during African Trypanosomiasis. J. Infect. Dis. 189:527-539 (IF 5.5, 12.2015 citation 53).

Saeftel, M., A. Kruger, S. Ariens, P. Racz, B. Fleischer, F. Brombacher, A. Hoerauf. 2004. Mice Deficient in Interleukin-4 (IL-4) or IL-4 Receptor alpha Have Higher Resistance to Sporozoite Infection with Plasmodium berghei (ANKA) than Do Naive Wild-Type Mice. Inf. & Immun., 72(1):322-331 (IF 3.7).

Stager, S., J. Alexander, M. Botto,  A. C. Kirby, N. Van Rooijen, D. F. Smith, F. Brombacher and P. M. Kaye. 2003. Natural antibodies and complement are endogenous adjuvants for vaccine-induced CD8+ T cell responses. Nature Medicine, 9:1287-92 (IF 27; 2.2012 citation = 96)

Linehan, S. A., P. S. Coulson, R. A. Wilson, A. P. Mountford, F. Brombacher, L. Martínez-Pomares and S. Gordon. 2003. IL-4 receptor signaling is required for mannose receptor expression by macrophages recruited to granulomata but not resident cells in mice infected with Schistosoma mansoni. Lab. Invest. 83:1223 – 31 (IF 4.4).

F. Brombacher, R. Kastelein, G. Alber. 2003.  Novel IL-12 family members uncovered in regulation of Th1 responses. Trends Immunol. 24:207-212 (IF 7; 2.2015 citation = 288)

Stager, S., Smith, D.F., Brombacher, F., Alexander, J., Kaye, P.M. 2003. Immunisation with a stage-regulated surface protein from Leishmania donovani protects wild-type but not IL-4 or IL-4Ra deficient mice against visceral leishmaniasis. Infec & Immun. 71(8):4804-7 (IF 3.7).

Herrmann, O., V. Tarabin, S. Suzuki, N. Attigah, I. Coserea, A. Schneider, J. Vogel, S. Prinz, S. Schwab, H. Monyer, F. Brombacher, M. Schwanninger. 2003. Regulation of body temperature and neuroprotection by endogenous Interleukin-6 in cerebral ischemia. J. Cereb. Blood Flow Metab. 4:406-415 (IF 2, 2.2012 citation = 56)

Volkmann, L., O. Bain, M. Saeftel, S. Specht, K. Fischer, F. Brombacher, K.I. Matthaei, A. Hoerauf. 2003. Murine filariasis: interleukin 4 and interleukin- 5 lead to containment of different worm developmental stages. Med. Microbiol. & Immunol. 192: 23-31. (IF 1.6).

Fincham, J. E., M. B. Markus, F. Brombacher. 2002. Vaccination against helminths: influence on HIV/AIDS and TB. Trends Parasitol. 18:385-6. (IF 7)

Noël W., Gh. Hassanzadeh, G. Raes, B. Namangala, I. Daems, L. Brys, F. Brombacher, P. De Baetselier and A. Beschin. (2002). Infection stage-dependent contribution of alternatively activated macrophages to resistance/susceptibility to Trypanosoma congolense. Infect. & Immun., 70:6180-87 (IF 3.7, 12.2015 citation =57).

Alexander, J., Brombacher, F., McGachy, A., Scott, P., McKenzie, A.N.J., Walker, W., and Carter, K.C. 2002. An essential role for IL-13 in maintaining a non-healing response following Leishmania mexicana infection. Europ. J. Immunol. 32:2923. (IF 6.0, 12.2015 citation = 53).

Kopf, M., B., F. Brombacher, M. F. Bachmann. 2002. Critical role of secreted IgM in protection against pulmonary influenza virus infection. Europ. J. Immunol. 32:2229-36. (IF 6.0).

Raes, G., P. De Baetselier, W. Noël, A. Beschin, F. Brombacher and Gh. Hassanzadeh. 2002. Differential expression of FIZZ1 and Ym1 in alternatively versus classically activated macrophages. J. Leukoc. Biol 71:597-602. (IF 4.5; 2.2015 citation = 351)

Hölscher, C.  R. A. Atkinson, B. Arendse, N. Brown, E. Myburgh, G. Alber, F. Brombacher 2001. A protective and agonistic function of interleukin-12p40 homodimer in mycobacterial infection. J. Immunol, 167:6957-66. (IF 7.4, 2.2015 citation = 224)

Eriksson, U., M. O. Kurrer, W. Seebald, F. Brombacher, M. Kopf. 2001. Dual role of IL-12/IFN-gamma axis in the development of autoimmune: Induction by IL-12 and protection by IFN-gamma. J. Immunol. 167:5464-5469 (IF 7.4; , 2.2012 citation = 66).

Grunewald, S. M., M. Teufel, K. Erb, A. Nelde, M. Welte, F. Brombacher, E. B. Bröcker, W. Sebald, A. Duschl. 2001. Upon prolonged allergen exposure IL-4 and IL-4Ralpha knockout mice produce specific IgE leading to anaphylaxis. Int Arch Allergy Immunol. 125:322-8. (IF 2).

Mueller, U., G. Koehler, H. Mossmann, G. A. Schaub, G. Alber, J. Di Santo, F. Brombacher, C. Hoelscher. 2001. IL-12-Independent IFN-gamma Production by T Cells in Experimental Chagas’Disease Is Mediated by IL-18. J. Immunol. 167:3346-53. (IF 7.4)

Biedermann, T., R. Mailhammer, A. Mai, C. Sander, A. Ogilvie, F. Brombacher, K. Maier, A. D. Levine, M. Röcken. 2001. Reversal of established delayed type hypersensitivity reactions following therapy with IL-4 or antigen-specific Th2 cells. Europ. J. Immunol. 31:1582-91. (IF 6.0).

Fort, M. M., R. Lesley, N. J. Davidson, S. Menon, , F. Brombacher, N. W. Leach, D. A. Rennick. 2001. Interleukin-4 exacerbates disease in a Th1 T cell transfer model of colitis. J. Immunol. 166:2793-2800 (IF 7.4, 2.2012 citation = 58).

Nickdel, M. B., F. Roberts, F. Brombacher, J. Alexander, C. W. Roberts. 2001. A counter-protective role for IL-5 during acute Toxoplasma gondii infection. Inf.&Immun. 69:1044-69 (IF 3.7).

Bregenholt, C., P. Berche, F. Brombacher, J. Di Santo. 2001. Conventional ab Tcells are sufficient for innate and adaptive immunity against enteric Listeria. monocytogenes. J. Immunol, 166:1871-76 (IF 7.4).

Mountford, A. P., K. G. Heal, P. S. Coulson, F. Brombacher. 2001. Signaling via IL-4 receptor alpha chain is required for protective vaccination against murine schistosomiasis. Inf. & Immun 69:228-236. .(IF 3.7)

Aebischer, T., S. Laforsch, R. Hurwitz, F. Brombacher, T. F. Meyer. 2001. Immunity against Helicobacter pylori infection in mice: a role for interleukin-4 receptor a chain and sex? Inf.&Immun.  69:556-558. .(IF 3.7) 3,276

Alexander, J., K.C. Carter., N. Al-Fasi, A. Satoskar, F. Brombacher. 2000. Endogenous IL-4 is necessary for effective drug therapy against visceral leishmaniasis.  Europ. J. Immunol. 30:2935-43. (I.F.= 6.0)

Brombacher, F. 2000. The role of interleukin-13 in infectious diseases and allergy. BioEssays. 22:646-656 (IF 7.3 2.2012 citation = 65).

Okano, M., A. R. Satoskar, M. Abe, D. A. Harn, M. Okana, K. Nishizaki, Y. Takeda, T. Yoshino, F. Brombacher, AA. Satoskar. 2000. Interleukin-4-independent production of Th2 cytokines by nasal lymphocytes and nasal eosinophilia in murine allergic rhinitis. Allergy. 55:723-31. (IF 6.2)

Houston, K. M., E. H. Wilson, L. Eyres, F. Brombacher, M. M. Harnett, J. Alexander, W. Harnett. 2000. Presence of phosphorylcholine on a filarial nematode protein influences immunoglobulin G subclass response to the molecule and by an interleukin-10-dependent mechanism. Inf.&Immun. 68:5466-68, (IF 3.7, 12.2015 citation = 53)

Hölscher, C., M. Mohrs, W. J. Dai, G. Köhler, B. Ryffel, G. A. Schaub, H. Mossmann, F. Brombacher. 2000. TNF-a-mediated toxic shock syndrome in Trypanosoma cruzi-infected IL-10 deficient mice. Inf. & Immun. 68:1773-80 .(IF 3.7 2.2012 citation = 65)

Mohrs, M., C. Hölscher, and F. Brombacher. 2000. IL-4Ra deficient Balb/c mice have an unimpaired Th2 polarization in response to Leishmania major infection. Inf.&Immun. 68:1773-80.(IF 3., 2.2012 citation = 55)

Ochsenbein, A. F., T. Fehr, C. Lutz, M. Suter, F. Brombacher, H. Hengartner, R. M. Zinkernagel. 1999. Control of early viral and bacterial distribution and disease by natural antibodies. Science. 286:2156-59 (IF 23, 2.2015 citation = 673).

Brewer, J., M. Conacher, M. C. A. Hunter, M. Mohrs, F. Brombacher, J. Alexander. 1999. Aluminium hydroxide adjuvant initiates strong antigen specifc Th2 responses in the absence of IL-4 and IL-13 mediated signaling. J. Immunol. 163:6448-54 (IF 7.4, 2.2015 citation = 347).

Mohrs, M., B. Ledermann, G. Koehler, A. Dorfmueller, A. Gessner, F. Brombacher. 1999. Differences between IL-4 and IL-4Ra deficient mice in chronic Leishmaniasis reveal a protective role for IL-13 receptor signalling. J. Immunol. 162:7302 (IF 7.4; 2.2012 citation = 142).

Vink, A., M-C. Many, G. Warnier, F. Brombacher, J-C. Renauld. 1999. IL-9-induced in vivo expansion of the B-1 lymphocyte population. J. Exp. Med. 189:1413-23 (IF 15.1; 2.2012 citation = 74).

Cohn, L., R. J. Homer, A. H. MacLeod, F. Brombacher, M. Mohrs, K. Bottomly. 1999. Th2 induced airway mucus production is dependent on IL-4Ra, but not on eosinophils. J. Immunol. 162:6178-83. (IF 7.4; 2.2015 citation = 248).

Brombacher, F., A. Dorfmüller, J. Magram, J. Ferrante, W. J. Dai, G. Köhler, A. Wunderlin, K. Palmer, M. K. Gately and G. Alber. 1999. Interleukin-12 is dispensable for protective immunity against low doses of Listeria monocytogenes. Intern. Immun. 11:325 (IF 3.8; 2.2012 citation = 70).

Grünig, G., M. Warnock, A. E. Wakil, R. Venkayya, F. Brombacher, D. M. Rennick, D. Sheppard, M. Mohrs, D. D. Donaldson, R. M. Locksley, D. B. Corry. 1998. Interleukin 13 and interleukin 4 mediate the asthmatic phenotype through interleukin 4 receptor a. Science, 282:2261-63. (IF 23; 2.2015 citation = 1726).

Bozza, M., M. B. P. Soares, P. T. Bozza, A. Satoskar, T. G. Diacovo, F. Brombacher, R. G. Titus, C. B. Shoemaker, J. R. David. 1998. The selective PACAP-type I receptor agonist Maxadilan from sand fly saliva protects mice against lethal endotoxemia. Eur. J. Immunol.  28: 3120-27. (IF 6.0)

Andersson, A., W. J. Dai, J. P. Di Santo, F. Brombacher. 1998. Innate immunity to Listeria in the absence of NK cells. J. Immunol, 161:5600 (IF 7.4)

Coyle, A.J., G., Köhler, S. Tsuyuki, F. Brombacher, and M., Kopf. 1998. Eosinophils are not required to induce airway hyperresponsiveness after nematode infection.  Eur. J. Immunol. 28:2640-7 (IF 7.4)

Lutz, C., B. Ledermann, M. Kosco-Vilbois, A. F. Ochsenbein, R. M. Zinkernagel, G. Köhler, F. Brombacher. 1998. IgD can largely substitute for loss of IgM function in B cells. Nature 393:797-801(IF 27.0; 2.2012 citation = 67).

Barner, M., M. Welte, F. Brombacher, M. Kopf. 1998. Differences between IL-4Ra and IL-4 deficient mice reveal a novel role of IL-13 in the regulation of T helper 2 cells and protection to nematode infection. Curr. Biol. 8:669-72 (IF 12.0; 2.2012 citation = 126).

Grunewald, S. M., A. Werthmann, B. Schnarr, C. E. Klein, E. B. Bröcker, M. Welte, F. Brombacher, W. Sebald, A. Duschl. 1998. Inhibition of the IL-4/IL-13 receptor system by a murine IL-4 mutant (QY) prevents the humoral response to allergen and the development of type I allergy in vivo. J. Immunol. 160:4004-9. (IF 7.4; 2.2012 citation = 91).

Hölscher, C., G. Köhler, U. Muller, H. Mossmann, G. A. Schaub, F. Brombacher. 1998. Defective NO effector functions lead to mortality in IFN-gR- and iNOS-deficient mice during acute infection withTrypanosoma cruzi. Infect. & Immun. 66:1208-15 (IF 3.7; 2.2012 citation = 143).

Alexander, J, H. Jebbari, H. Blüthmann, F. Brombacher, C. W. Roberts. The role of IL-4 in adult acquired and congenital toxoplasmosis. 1998. Intern. J. Parasit., 28:113-20 (IF 1.0)

Satoskar, A., F. Brombacher, W. J. Dai, I. McInnes, F. Y. Liew, J. Alexander and W. Walker. 1997. Severe combined immunodeficient mice reconstituted with IL-4 deficient lymphocytes but not immunocompetent lymphocytes are resistant to cutanous leishmaniosis. J. Immunol. 159:5005-13 (IF 7.4)

Noben-Trauth, N.,  L. D. Shultz, F. Brombacher, J. F. Urban, H. Gu, W. E. Paul. 1997. An Interleukin 4 (IL-4)-independent pathway for CD4+ T cell IL-4 production is revealed in IL-4 receptor-deficient mice. Proc. Natl. Acad. Sci. USA. 94:10838-43 (IF 10.5; 2.2015 citation = 295).

Monteyne, P., J. C. Renauld, J. Van Broeck, D. W. Dunne, R. Kühn, F. Brombacher and J.-P. Coutelier. 1997. IL-4 independent regulation of in vivo IL-9 expression. J. Immunol. 159:2616-23. (IF 7.4)

Dai, W. J., W. Bartens, G. Köhler, M. Hufnagel, M. Kopf and F. Brombacher. 1997. Impaired macrophage listericidal and cytokine activities are responsible for the rapid death of Listeria monocytogenes infected IFN-g -receptor deficient mice. J. Immunol. 158: 5297. (IF 7.4 2.2012 citation = 103).

Nielsen, P. J., B. Lorenz, A. M. Müller, R. H. Wenger, F. Brombacher, M. Simon, T. Von der Weid, H. Mossmann and G. Köhler. 1997. Altered erythrocytes and a leaky block in B-cell development in CD24/HSA-deficient mice. Blood 89:1058. (IF 12.0, 2.2012 citation = 2.2012 citation = 54).

Dai, W. D., G. Köhler and F. Brombacher. 1997. Both innate and acquired immunity to Listeria monocytogenes infection are increased in IL-10 deficient mice. J. Immunol. 158:2259. (IF 7.4; 2.2012 citation = 114).

Kopf, M., F. Brombacher, G. Kienzle, K.-H. Widmann, K. Lefranc, C. Humborg, B. Ledermann and W. Solbach. 1996. IL-4-deficient mice without elevating Th1 responses resist infection with Leishmania major. J. Exp. Med. 184:1127. (IF 15.1; 2.2015 citation = 243).

Battegay, M., P. Fiedler, U. Kalinke, F. Brombacher, R. M. Zinkernagel, H-H. Peter, G. Köhler, H. Eibel. 1996. Non-tolerant B cells cause autoimmunity in anti-CD8 IgG2a-transgenic mice. Eur. J. Immunol. 26:250. (IF 6.0) 748

Brombacher, F. and M. Kopf. 1996. Innate versus acquired immunity in Listeriosis. Res. Immunol.  147:505. (IF 1.3)

Kopf, M., F. Brombacher, P. Hodkin, E. Milbourne, W. J. Dai, C. Beam, I. G. Young, G. Köhler and K. Matthaei. 1996. Developmental defect in CD5+ B-1 cells and lack of eosinophilia in IL-5 deficient mice.  Immunity 4:15. (IF 20 2.2015 citation = 513).

Kopf, M., A. Ramsay, F. Brombacher, H. Baumann, G. Freer, C. Galanos, R. J. Gutierrez and G. Köhler. 1995. Pleiotropic defects of IL-6-deficient mice including early hematopoiesis, T and B cell function, and acute phase responses. Ann. N.Y. Acad. Sciences 762:308. (I.F.= 0.8; 2.2012 citation = 57).

Kopf, M., G. LeGros, A. Coyle, M. Kosco-Vilbois and F. Brombacher. 1995. Immune responses of IL-4, IL-5, IL-6 deficient mice. Immunol. Rev. 148:45. (IF 5.9 2.2012 citation = 103).

Brombacher, F., T. Schäfer, U. Weissenstein, C. Tschopp, E. Andersen, K. Bürki and G. Baumann. 1994. IL-2 promoter-driven lacZ expression as a monitoring tool for IL-2 expression in primary T cells of transgenic mice. Intern. Immunol. 6:189. (IF 4.3)

Eibel, H., F. Brombacher and G. Köhler. 1992. Analysis of B-cell tolerance in mice expressing transgenic anti-CD8.2 immunoglobulin M molecules. Res. Immunol. 143:276. (IF 1.3)

Brombacher, F., G. Köhler and H. Eibel. 1991. B cell tolerance in mice transgenic for anti-CD8 immunoglobulin m chain. J. Exp. Med. 174:1335. (IF 15.1)

Berling, B., F. Kolbinger, F. Grunert, J. A. Thompson, F. Brombacher, F. Buchegger, K. S. von Kleist, and W. Zimmermann. 1990. Cloning of a carcino- embryonic antigen gene family member expressed in leukocytes of chronic myeloid leukemia patients and bone marrow. Cancer Res. 50:6534. (IF 5.2; 2.2012 citation = 87).

Brombacher, F., M. C. Lamers, G. Kohler and H. Eibel. 1989. Elimination of CD8(+) thymocytes in transgenic mice expressing an anti-Lyt2.2 immunoglobulin heavy chain gene. EMBO J.8:3719. (IF 12.6)

Kolbinger, F., K. Schwarz, F. Brombacher, K. S. von Kleist, and F. Grunert. 1989. Expression of an NCA cDNA in NIH/3T3 cells yields a 110K glycoprotein, which is anchored into the membrane via glycosyl-phosphatidylinositol. Biochem. Biophys. Res. Comm. 161:1126. (IF 3.6)

Books/Chapters/Commenteries

Macrophages and Dendritic Cells. Methods and Protocolls. Editor N.E. Reiner Title: Analyzing classical and alternative macrophage activation in macrophage/neutrophil-specific IL-4 receptor-alpha-deficient mice. F. Brombacher, B Arendse, R. Peterson, A. Hoelscher, C. Hoelscher. Pp 225-252 Humana Press (2009) ISBN: 978-1-58829-972-7

Advances in the Immunobiology of Parasitic Diseases, Editor: L. I. Terrazas Title: Alternatively activated macrophages in experimental parasitic infections by  WGC Horsnell and F. Brombacher. pp 1 – 20 Research Signpost, 37/661(2) Fort, P.O. Trivandrum- 695 023 (2007), ISBN: 81-308-0166-3

A paradise for pathogens and parasites? F. Brombacher (2006), Crystal Ball:, Parasite Immunology, 28: 235-69.

Nieuwenhuizen, N., A. L. Lopata, M. F. Jeebhay, D. R. Herbert, T. G.Robins, F. Brombacher (2006). J Allergy Clin Immunol. 968-9 (I.F. = 9)

Interleukin 13, Editor F. Brombacher, (2003) Landes Bio, Georgetown, Texas, USA

FANTOM Consortia papers

The Constrained Maximal Expression Level Owing to Haploidy Shapes Gene Content on the Mammalian X Chromosome. Hurst LD, Ghanbarian AT, Forrest AR; FANTOM consortium, Huminiecki L. PLoS Biol. 2015 Dec 18;13(12):e1002315.

Application of Gene Expression Trajectories Initiated from ErbB Receptor Activation Highlights the Dynamics of Divergent Promoter Usage. Carbajo D, Magi S, Itoh M, Kawaji H, Lassmann T, Arner E, Forrest AR, Carninci P, Hayashizaki Y, Daub CO; FANTOM consortium, Okada-Hatakeyama M, Mar JC. PLoS One. 2015 Dec 14;10(12):e0144176.

The statistical geometry of transcriptome divergence in cell-type evolution and cancer.

Liang C; FANTOM Consortium, Forrest AR, Wagner GP. Nat Commun. 2015

CCL2 enhances pluripotency of human induced pluripotent stem cells by activating hypoxia related genes. Hasegawa Y, Tang D, Takahashi N, Hayashizaki Y, Forrest AR; FANTOM Consortium, Suzuki H. Sci Rep. 2014 Jun 24;4:5228.

Differential roles of epigenetic changes and Foxp3 expression in regulatory T cell-specific transcriptional regulation.

Morikawa H, Ohkura N, Vandenbon A, Itoh M, Nagao-Sato S, Kawaji H, Lassmann T, Carninci P, Hayashizaki Y, Forrest AR, Standley DM, Date H, Sakaguchi S; FANTOM Consortium.

Proc Natl Acad Sci U S A. 2014 Apr 8;111(14):5289-94.

Ceruloplasmin is a novel adipokine which is overexpressed in adipose tissue of obese subjects and in obesity-associated cancer cells.

Arner E, Forrest AR, Ehrlund A, Mejhert N, Itoh M, Kawaji H, Lassmann T, Laurencikiene J, Rydén M, Arner P; FANTOM Consortium.

PLoS One. 2014 Mar 27;9(3):e80274.

An atlas of active enhancers across human cell types and tissues.

Andersson R, Gebhard C, Miguel-Escalada I, Hoof I, Bornholdt J, Boyd M, Chen Y, Zhao X, Schmidl C, Suzuki T, Ntini E, Arner E, Valen E, Li K, Schwarzfischer L, Glatz D, Raithel J, Lilje B, Rapin N, Bagger FO, Jørgensen M, Andersen PR, Bertin N, Rackham O, Burroughs AM, Baillie JK, Ishizu Y, Shimizu Y, Furuhata E, Maeda S, Negishi Y, Mungall CJ, Meehan TF, Lassmann T, Itoh M, Kawaji H, Kondo N, Kawai J, Lennartsson A, Daub CO, Heutink P, Hume DA, Jensen TH, Suzuki H, Hayashizaki Y, Müller F; FANTOM Consortium, Forrest AR, Carninci P, Rehli M, Sandelin A.

Nature. 2014 Mar 27;507(7493):455-61.

Brombacher, T.M., J.K. Nono K.S. De Gouveia, N. Makena, M. Darby, J. Womersley, O. Tamgue, and F. Brombacher  2017. IL-13–Mediated Regulation of Learning and Memory. Journal of Immunology, 198:2681-88

Oetjen LK, Mack MR, Feng J, Whelan TM, Niu H, Guo CJ, Chen S, Trier AM, Xu AZ, Tripathi SV, Luo J, Gao X, Yang L, Hamilton SL, Wang PL, Brestoff JR, Council ML, Brasington R, Schaffer A, Brombacher F, Hsieh CS, Gereau RW 4th, Miller MJ, Chen ZF, Hu H, Davidson S, Liu Q, Kim BS. 2017. Sensory Neurons Co-opt Classical Immune Signaling Pathways to Mediate Chronic Itch. Cell. 171:217-228.

White AJ, Baik S, Parnell SM, Holland AM, Brombacher F, Jenkinson WE, Anderson G. 2017. A type 2 cytokine axis for thymus emigration. J Exp Med. 214:2205-16.

Pelly VS, Coomes SM, Kannan Y, Gialitakis M, Entwistle LJ, Perez-Lloret J, Czieso S, Okoye IS, Rückerl D, Allen JE, Brombacher F, Wilson MS. 2017. Interleukin 4 promotes the development of ex-Foxp3 Th2 cells during immunity to intestinal helminths. J Exp Med. 23:623-30

Fischer K, HH Ruiz, K Jhun, B Finan, DJ Oberlin, V van der Heide, A V Kalinovich, N Petrovic, Y Wolf, C Clemmensen, A C Shin, S Divanovic, F Brombacher, E Glasmacher, S Keipert, M Jastroch,
J Nagler, K-W Schramm, D Medrikova, G Collden, S C Woods, S Herzig, D Homan, S Jung, J Nedergaard, B Cannon, MH Tschöp, T D Müller & C Buettner 2017. Alternatively activated macrophages do not synthesize catecholamines or contribute to adipose tissue adaptive thermogenesis. Nature Medicine, 23:623-30

Kirstein F, Nieuwenhuizen NE, Jayakumar J, Horsnell WG, Brombacher F. 2016. Role of IL-4 receptor α-positive CD4+ T cells in chronic airway hyperresponsiveness. J Allergy Clin Immunol. 137:1852-62.

Reto Guler & Frank Brombacher. Host-directed drug therapy for tuberculosis. 2015. Nature Chemical Biology. 11:1-4

Roy S, Schmeier S, Arner E, Alam T, Parihar SP, Ozturk M, Tamgue O, Kawaji H, de Hoon MJ, Itoh M, Lassmann T, Carninci P, Hayashizaki Y, Forrest AR, Bajic VB, Guler R, Consortium F, Brombacher F*, Suzuki H. * 2015. Redefining the transcriptional regulatory dynamics of classically and alternatively activated macrophages by deepCAGE transcriptomics. Nucleic Acids Res. 18:6969-82 * corresponding author

Arner E, Daub CO, Vitting-Seerup K, Andersson R, Lilje B, Drabløs F, Lennartsson A, Rönnerblad M, Hrydziuszko O, Vitezic M, Freeman TC, Alhendi AM, Arner P, Axton R, Baillie JK, Beckhouse A, Bodega B, Briggs J, Brombacher F, Davis M, Detmar M, Ehrlund A, Endoh M, Eslami A, Fagiolini M, Fairbairn L, Faulkner GJ, Ferrai C, Fisher ME, Forrester L, Goldowitz D, Guler R, Ha T, Hara M, Herlyn M, Ikawa T, Kai C, Kawamoto H, Khachigian LM, Klinken SP, Kojima S, Koseki H, Klein S, Mejhert N, Miyaguchi K, Mizuno Y, Morimoto M, Morris KJ, Mummery C, Nakachi Y, Ogishima S, Okada-Hatakeyama M, Okazaki Y, Orlando V, Ovchinnikov D, Passier R, Patrikakis M, Pombo A, Qin XY, Roy S, Sato H, Savvi S, Saxena A, Schwegmann A, Sugiyama D, Swoboda R, Tanaka H, Tomoiu A, Winteringham LN, Wolvetang E, Yanagi-Mizuochi C, Yoneda M, Zabierowski S, Zhang P, Abugessaisa I, Bertin N, Diehl AD, Fukuda S, Furuno M, Harshbarger J, Hasegawa A, Hori F, Ishikawa-Kato S, Ishizu Y, Itoh M, Kawashima T, Kojima M, Kondo N, Lizio M, Meehan TF, Mungall CJ, Murata M, Nishiyori-Sueki H, Sahin S, Nagao-Sato S, Severin J, de Hoon MJ, Kawai J, Kasukawa T, Lassmann T, Suzuki H, Kawaji H, Summers KM, Wells C; FANTOM Consortium, Hume DA, Forrest AR, Sandelin A, Carninci P, Hayashizaki Y. 2015.  Transcribed enhancers lead waves of coordinated transcription in transitioning mammalian cells. Science. 347:1010-4.

FANTOM Consortium and the RIKEN PMI and CLST (DGT), Forrest AR, Kawaji H, Rehli M, Baillie JK, de Hoon MJ, Haberle V, Lassmann T, Kulakovskiy IV, Lizio M, Itoh M, Andersson R, Mungall CJ, Meehan TF, Schmeier S, Bertin N, Jørgensen M, Dimont E, Arner E, Schmidl C, Schaefer U, Medvedeva YA, Plessy C, Vitezic M, Severin J, Semple C, Ishizu Y, Young RS, Francescatto M, Alam I, Albanese D, Altschuler GM, Arakawa T, Archer JA, Arner P, Babina M, Rennie S, Balwierz PJ, Beckhouse AG, Pradhan-Bhatt S, Blake JA, Blumenthal A, Bodega B, Bonetti A, Briggs J, Brombacher F, et al. 2014. A promoter-level mammalian expression atlas. Nature. 507:462-70.

Hurdayal, R., N.E. Nieuwenhuizen, M. Revaz-Breton, L. Smith1, J.C. Hoving, S.P. Parihar, B.Reizis and F.Brombacher. 2013. Deletion of IL-4 receptor alpha on dendritic cells renders BALB/c mice hypersusceptible to Leishmania major infection. PLOSpathogen 9:e1003699.

Horsnell, WGC, M Darby, JC Hoving, N Nieuwenhuizen, S Bobat, H Ndlovu, M Kimberg, F Brombacher. 2013. Rapid 4R<alpha> associated antigen processing by B cells promotes recall immunity in Nippostrongylus brasiliensis infection. 2013. PLOSpathogen 9:e1003662.

Nieuwenhuizen NE, Kirstein F, Jayakumar J, Emedi B, Hurdayal R, Horsnell W, Brombacher F 2012. Allergic airway disease is unaffected by the absence of IL-4Ra-dependent alternatively activated macrophages. J Allergy Clin Immunol, 130:743-50.