Elizabeth Ficher

Monday, 17 September 2018 | 12:00 noon

Department of Neuromuscular Diseases, Institute of Neurology, Faculty of Brain Sciences,UCL, Institutional Research Information Service, London, UK

Physiological mouse models of neurodegeneration

(Host: E. Buratti)

Motor neuron disease, also known as amyotrophic lateral sclerosis, is a relentless mid-life onset form of neurodegeneration that is largely untreatable and certainly incurable.

It starts focally and leads to paralysis and death, typically within 3 years of diagnosis. Mouse models are helping to tease out the mechanism of ALS, which now turns out to have over 20 causative genes. However, there are still many challenges, including in translation. Here, some models are presented that have given us new insights.