17-20 April 2018, Trieste, Italy
Drosophila models of neurological disease are essential to understand complex human diseases in many different aspects of the biomedical research. The programme of the course will cover the latest achievements in Drosophila state-of-the-art methodologies aimed to the accurate representation of human disease and the design of innovative therapeutic approaches. The course is particularly aimed to train ICGEB member countries students and young scientists interested in adopting Drosophila as experimental system. To maximize the benefit of the programme, priority will be given to participants already working with this model organism. The event will start with an introduction of Drosophila neurogenetics. This will be followed by an overview of various strategies to induce cell-type specific gene expression or silencing in the nervous system. In parallel, the course will also instruct participants on how to measure synaptic activity, perform in vivoimaging analysis, assess complex behaviors and evaluate these Drosophila traits in a quantitative manner. These topics will be examined using recent examples of disease model that have been developed and are being actively used by all the faculty members.
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A. Giangrande , USIAS, Strasbourg, FRANCE
Cell-Specific epigenetic signatures in the nervous system
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T. Vaccari , University of Milan, ITALY
Regulation of autophagy in health and disease
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F. Feiguin , ICGEB Trieste, ITALY
Neuronal and extraneuronal mechanism of neurodegeneration in ALS
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G. Gilestro , Imperial College London, UK
What flies can teach us about sleep
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G. Gilestro , Imperial College London, UK
Analysing and manipulating sleep in Drosophila
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T. Weil , University of Cambridge, UK
mRNA biology and local translation
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A. Hidalgo , University of Birmingham, UK
The molecular mechanism of glial regeneration and CNS repair
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P. Bellosta , University of Trento, Italy
Neuronal death and cell survival a tight balance controlled
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T. Vaccari , University of Milan, ITALY
Roles of the trafficking machinery in neurodegeneration
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A. Giangrande , USIAS, Strasbourg, FRANCE
From neural stem cells to glial differentiation
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A. Whitworth, University of Cambraidge, UK
Mitochondrial dysregulation in Parkinson’s disease – lesson from Drosophila – part 1
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A. Whitworth, University of Cambraidge, UK
Mitochondrial dysregulation in Parkinson’s disease – lesson from Drosophila – part 2
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A. Megighian , University of Padua, ITALY
Drosophila melanogaster: from neurophysiology to behavior
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T. Weil , University of Cambridge, UK
The function of bimolecular condensate in translational regulation during development…
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A. Hidalgo , University of Birmingham, UK
The regenerative potential of glial cells
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