Professor of Pharmacology, Director Laboratory of Lipoproteins, Immunity and Atherosclerosis, Department of Pharmacological and Biomolecular Sciences “Rodolfo Paoletti”, Coordinator Doctorate School of Pharmacological and Biomolecular Sciences, Experimental and Clinical, University of Milan, ITALY – SISA Center for the Study of Atherosclerosis, Bassini Hospital
Immunometabolic reprogramming of T cells in obesity and cardiometabolic disorders
Host: A. Muro
Metabolic reprogramming is a physiological cellular adaptation to intracellular and extracellular stimuli that couples to cell polarization and function in multiple cellular subsets. Pathological conditions associated to nutrients overload, such as dyslipidaemia, may disturb cellular metabolic homeostasis and, in turn, affect cellular response and activation, thus contributing to disease progression. This seminar will focus on the impact of changes in sterols and lipid metabolism on innate and adaptive immune cells in the context of cardiometabolic disorders, including metabolic syndrome and obesity. The impact of apoE, ApoA-I and LDL-R deficiencies on cellular metabolism and function of dendritic cells and lymphocytes T cells will be discussed together with the implications for immune response.
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