NON-COMMUNICABLE DISEASES / Immunology
Research Interests
Cancer induced immune suppression, intracellular trafficking of endosomal innate sensors and type-I interferon production in myeloid cells.
Description of Research
The lab focus is on cell biology of phagocytes and antigen presenting cells in healthy conditions and in pathological conditions like cancer and immune dysregulation. A major research line is dedicated to understanding how tumors cripple antigen presentation and myeloid functions in tissues. A second research line is dedicated to study cytoskeletal remodeling in phagocytes and its impact on innate signaling pathway using Wiskott-Aldrich syndrome as a disease model.
The lab also runs one of ICGEB’s Core Facilities: flow cytometry
Recent Publications
Piperno, G.M., Naseem, A., Silvestrelli, G., Amadio, R., Caronni, N., Cervantes-Luevano, K.E., Liv, N., Klumperman, J., Colliva, A., Ali, H., Graziano, F., Benaroch, P., Haecker, H., Hanna, R.N., Benvenuti, F. 2020. Wiskott-Aldrich syndrome protein restricts cGAS/STING activation by dsDNA immune complexes. JCI insight. DOI: 10.1172/jci.insight.132857
Del Prete, A., Sozio, F., Schioppa, T., Ponzetta, A., Vermi, W., Calza, S., Bugatti, M., Salvi, V., Bernardini, G., Benvenuti, F., Vecchi, A., Bottazzi, B., Mantovani, A., Sozzani, S. 2019. The Atypical Receptor CCRL2 Is Essential for Lung Cancer Immune Surveillance. Cancer Immunol Res. 2019 Nov;7(11):1775-1788. doi: 10.1158/2326-6066.CIR-19-0168
Cervantes-Luevano, K.E., Caronni, N., Castiello, M.C., Fontana, E., Piperno, G., Naseem, A., Uva, P., Bosticardo, M., Marcovecchio, G.E., Notarangelo, L.D., Cicalese, M.P., Aiuti, A., Villa, A., Benvenuti, F. 2018. Neutrophils drive type-I interferon production and autoantibodiesin Wiskott-Aldrich syndrome. J Allergy Clin Immunol pii:S0091-6749(18)30207-0. doi: 10.1016/j.jaci.2017.11.063. [Epub ahead of print] PubMed link
Caronni, N., Simoncello, F., Stafetta, F., Guarnaccia, C., Ruiz-Moreno, J.S., Opitz, B., Galli, T., Proux-Gillardeaux, V., Benvenuti, F. 2017. Downregulation of membrane trafficking proteins and lactate conditioning determine loss of dendritic cell function in lung cancer. Cancer Res. 2018 Jan 23. pii: canres.1307.2017. doi:
10.1158/0008-5472.CAN-17-1307. [Epub ahead of print] PubMed link
Campaner, E., Rustighi, A., Zannini, A., Cristiani, A., Piazza, S., Ciani, Y., Kalid, O., Golan, G., Baloglu, E., Shacham, S., Valsasina, B., Cucchi, U., Pippione, A.C., Lolli, M.L., Giabbai, B., Storici, P., Carloni, P., Rossetti, G., Benvenuti, F., Bello, E., D’Incalci, M., Cappuzzello, E., Rosato, A., Del Sal, G. 2017. A covalent PIN1 inhibitor selectively targets cancer cells by a dual mechanism of action. Nat Commun 9, 15772 PubMed link
Castiello MC, Pala F, Sereni L, Draghici E, Inverso D, Sauer AV, Schena F, Fontana E, Radaelli E, Uva P, Cervantes-Luevano KE, Benvenuti F, Poliani PL, Iannacone M, Traggiai E, Villa A, Bosticardo M. “In Vivo Chronic Stimulation Unveils Autoreactive Potential of Wiskott-Aldrich Syndrome Protein-Deficient B Cells”. Front Immunol. 2017 May 2;8:490. doi: 10.3389/fimmu.2017.00490
