NON-COMMUNICABLE DISEASES / Cardiovascular Disorders
Cell-cell interactions and cross-talk in angiogenesis, cancer and cardiac disease
Description of Research
Research projects focus on angiogenesis and aim to identify the mechanisms by which endothelial cells interact and comunicate with the other cell types composing the cardiovascular system. Particular interest is dedicated to the cross-talk between endothelial cells and cardiomyocytes in the heart. Thanks to established collaborations with multiple clinical units, the laboratory is particularly dedicated to the use of cellular and animal models of human diseases, as well as of viral and non-viral gene transfer approaches, to eventually develop novel therapeutic approaches for tissue revascularization and cancer treatment.
A second interest of the Group is in the field of laser light, where the major interest is in understanding how light interact with cells and tissue and in exploiting light to develop innovative therapeutic opportunities.
Zacchigna S, Paldino A, Falcão-Pires I, Daskalopoulos EP, Dal Ferro M, Vodret S, Lesizza P, Cannatà A, Miranda-Silva D, Lourenço AP, Pinamonti B, Sinagra G, Weinberger F, Eschenhagen T, Carrier L, Kehat I, Tocchetti CG, Russo M, Ghigo A, Cimino J, Hirsch E, Dawson D, Ciccarelli M, Oliveti M, Linke WA, Cuijpers I, Heymans S, Hamdani N, de Boer M, Duncker D, Kuster D, van der Velden J, Beauloye C, Bertrand L, Mayr M, Giacca M, Leuschner F, Backs J, Thum T on behalf of the Working Group on Myocardial Function of the European Society of Cardiology. Toward standardization of echocardiography for the evaluation of left ventricular function in adult rodents: a position paper of the ESC Working Group on Myocardial Function. Cardiovasc Res 2020, May 4:cvaa110. doi: 10.1093/cvr/cvaa110. PubMed
Kocijan, T, Rehman M, Colliva A, Leban M, Vodret S, Volf N, Zucca G, Cappelletto A, Zhou B, Adams R, Zentilin L, Giacca M and Zacchigna S. Genetic lineage tracing reveals poor angiogenic potential of cardiac endothelial cells. Cardiovasc Res 2020 Jan 30:cvaa012. doi: 10.1093/cvr/cvaa012. PubMed
Rupel K, Zupin L, Ottaviani G, Bertani I, Martinelli V, Porrelli D, Vodret S, Vuerich R, Passos da Silva D, Bussani R, Crovella S, Parsek M, Venturi V, Di Lenarda R, Biasotto M, and Zacchigna S. Blue laser light inhibits biofilm formation in vitro and in vivo by inducing oxidative stress. npj Biofilms and Microbiomes, 2019 Oct 9;5:29. PubMed
Torrini C, Cubero RJ, Dirkx E, Braga L, Ali H, Prosdocimo G, Gutierrez MI, Collesi C, Licastro D, Zentilin L, Mano M, Zacchigna S, Vendruscolo M, Marsili M, Samal A, Giacca M. Common Regulatory Pathways Mediate Activity of MicroRNAs Inducing Cardiomyocyte Proliferation. Cell Rep. 2019 May 28;27(9):2759-2771. PubMed
Gabisonia K, Prosdocimo G, Aquaro GD, Carlucci L, Zentilin L, Secco I, Ali H, Braga L, Gorgodze N, Bernini F, Burchielli S, Collesi C, Zandonà L, Sinagra G, Piacenti M, Zacchigna S, Bussani R, Recchia FA, Giacca M. MicroRNA therapy stimulates uncontrolled cardiac repair after myocardial infarction in pigs. Nature. 2019 May;569(7756):418-422. Pubmed
Cappelletto A, Zacchigna S. Cardiac revascularization: state of the art and perspectives. Vascular Biology. 2019; 1 (1)R1-R5.