NON-COMMUNICABLE DISEASES / Cardiovascular Disorders
Cell-cell interactions and cross-talk in angiogenesis, cancer and cardiac disease
Description of Research
Research projects focus on angiogenesis and aim to identify the mechanisms by which endothelial cells interact and comunicate with the other cell types composing the cardiovascular system. Particular interest is dedicated to the cross-talk between endothelial cells and cardiomyocytes in the heart. Thanks to established collaborations with multiple clinical units, the laboratory is particularly dedicated to the use of cellular and animal models of human diseases, as well as of viral and non-viral gene transfer approaches, to eventually develop novel therapeutic approaches for tissue revascularization and cancer treatment.
A second interest of the Group is in the field of laser light, where the major interest is in understanding how light interact with cells and tissue and in exploiting light to develop innovative therapeutic opportunities.
Lesizza, P., Prosdocimo, G., Martinelli, V., Sinagra, G., Zacchigna, S., Giacca, M. 2017. Single-Dose Intracardiac Injection of Pro-Regenerative MicroRNAs Improves Cardiac Function After Myocardial Infarction. Circ Res 120, 1298-1304 PubMed link
Bortolotti, F., Ruozi, G., Falcione, A.,Doimo, S., Dal Ferro, M., Lesizza, P., Zentilin, S., Giacca, M. 2017. In Vivo Functional Selection Identifies Cardiotrophin-1 as a Cardiac Engraftment Factor for Mesenchymal Stromal Cells. Circulation doi: 10.1161/CIRCULATIONAHA.117.029003. [Epub ahead of print]
Zanotti, L., Angioni, R., Calì, B., Soldani, C., Ploia, C., Moalli, F., Gargesha, M., D’Amico, G., Elliman, S, Tedeschi, G., Maffioli, E., Negri, A., Zacchigna, S., Sarukhan, A., Stein, J.V., Viola, A. 2016. Mouse mesenchymal stem cells inhibit high endothelial cell activation and lymphocyte homing to lymph nodes by releasing TIMP-1. Leukemia. 22. doi: 10.1038/leu.2016.33. PubMed link
Ottaviani, G., Martinelli, V., Rupel, K., Caronni, N., Naseem, A., Zandonà, L., Perinett, G., Gobbo, M., Di Lenarda, R., Bussani, R., Bevnvenuti, F., Giacca, M., Biasotto, M. Zacchigna, S. 2016. Laser Therapy Inhibits Tumor Growth in Mice by Promoting Immune Surveillance and Vessel Normalization. EBioMedicine 11, 165-172 PubMed link
Kazemi, M., Carrer, A., Moimas S., Zandonà L., Bussani R., Casagrande B., Palmisano S., Prelazzi P., Giacca M., Zentilin L., De Manzini, N., Giacca M., Zacchigna S. 2016. VEGF121 and VEGF165 differentially promote vessel maturation and tumor growth in mice and humans. Cancer Gene Therapy 23(5):125-32. PubMed link
Mano, M., Ippodrino, R., Zentilin, L., Zacchigna, S., Giacca, M. 2015. Genome-wide RNAi screening identifies host restriction factors critical for in vivo AAV transduction. Proc Natl Acad Sci U S A. 2015 Sep 8;112(36):11276-81. PubMed link