Group Leader, Structural Biology
International Centre for Genetic Engineering and Biotechnology
Aruna Asaf Ali Marg
110 067 New Delhi, India
E-mail: [email protected], [email protected]
Tel: +91-11-26741358 ext. 172
Fax: +91-11-26742316
Education
Madurai Kamaraj University, Madurai, India, PhD, 2000
Madurai Kamaraj University, Madurai, India, MSc, 1993
Career History
2024-to date: Group Leader, Structural Biology Group, International Centre for Genetic Engineering and Biotechnology (ICGEB) New Delhi, India
2016-2024: Group Leader, Membrane Protein Biology Group, International Centre for Genetic Engineering and Biotechnology (ICGEB) New Delhi, India
2006-2015: Staff Research Scientist, Structural and Computational Biology Group, ICGEB, New Delhi, India
2003-2006: Assistant Research Scientist, Texas A&M University, Texas, USA
2001-2003: Post-doctoral Research Associate, Texas A&M University
2000-2001: Post-doctoral Research Associate, University of Illinois at Chicago, Illinois, USA
1994-2000: PhD, Junior and Senior Research Fellow (CSIR-NET), Madurai Kamaraj University, India
1993-1994: Junior Research Fellow, Anna University, Chennai, India
Scientific Activity
Our research is dedicated to early-stage drug discovery, specifically focusing on the development of structure-based therapeutics for ASCVD and cancer. We use cutting-edge CADD techniques to identify, design, and optimize potential drug candidates. These candidates undergo extensive and rigorous in vitro validation through biochemical, biophysical, and cell-based assays. Promising candidates are further evaluated in in vivo mouse models to assess their safety, efficacy, and pharmacokinetic characteristics and moves them closer to the point of filing an IND and beginning clinical trials. Our main objective is to find and create tailored treatments that can dramatically lower death rates and enhance the quality of life for those afflicted with these devastating diseases.
Selected publications
Khan, Mohd Azeem, Irshad Mohammad, Sohom Banerjee, Akanksha Tomar, Kottayil I. Varughese, Jawahar L. Mehta, Anmol Chandele, and Arulandu Arockiasamy. “Oxidized LDL receptors: a recent update.” Current Opinion in Lipidology 34, no. 4 (2023): 147-155. DOI: 10.1097/MOL.0000000000000884.
https://doi.org/10.1097/MOL.0000000000000884
Tomar, Akanksha, Sibasis Sahoo, Muthusankar Aathi, Shobhan Kuila, Mohd Azeem Khan, Guru Raj Rao Ravi, Jeyakanthan Jeyaraman, Jawahar L. Mehta, Kottayil I. Varughese, and Arulandu Arockiasamy. “Exploring the druggability of oxidized low-density lipoprotein (ox-LDL) receptor, LOX-1, a proatherogenic drug target involved in atherosclerosis.” Biochemical and Biophysical Research Communications 623 (2022): 59-65. https://doi.org/10.1016/j.bbrc.2022.07.036
Pothineni, Naga Venkata K., Sotirios K. Karathanasis, Zufeng Ding, Arockiasamy Arulandu, Kottayil I. Varughese, and Jawahar L. Mehta. “LOX-1 in atherosclerosis and myocardial ischemia: biology, genetics, and modulation.” Journal of the American College of Cardiology 69, no. 22 (2017): 2759-2768.https://doi.org/10.1016/j.jacc.2017.04.010
Sonkar, Kirti Shila, V. Mohan Murali Achary, Sibasis Sahoo, Malireddy K. Reddy, and Arulandu Arockiasamy. “Biochemical and structural characterization of a robust and thermostable ascorbate recycling monodehydroascorbate reductase (MDHAR) from stress adapted pearl millet.” Biochemical and Biophysical Research Communications 662 (2023): 135-141. https://doi.org/10.1016/j.bbrc.2023.04.034
Das, Bhaba Krishna, Wajahat Ali Khan, Sreeshma Nellootil Sreekumar, Kannapiran Ponraj, V. Mohan Murali Achary, Elluri Seetharami Reddy, D. Balasubramaniam, Anmol Chandele, Malireddy K. Reddy, and Arulandu Arockiasamy. “Plant dehydroascorbate reductase moonlights as membrane integrated ion channel.” Archives of Biochemistry and Biophysics 741 (2023): 109603. https://doi.org/10.1016/j.abb.2023.109603
Das, Bhaba Krishna, Amit Kumar, Sreeshma Nellootil Sreekumar, Kannapiran Ponraj, Kaustubh Gadave, Saravanan Kumar, V. Mohan Murali Achary, Pratima Ray, Malireddy K. Reddy, and Arulandu Arockiasamy. “Comparative kinetic analysis of ascorbate (Vitamin-C) recycling dehydroascorbate reductases from plants and humans.” Biochemical and Biophysical Research Communications 591 (2022): 110-117. https://doi.org/10.1016/j.bbrc.2021.12.103
Panchariya, Love, Wajahat Ali Khan, Shobhan Kuila, Kirtishila Sonkar, Sibasis Sahoo, Archita Ghoshal, Ankit Kumar et al. “Zinc 2+ ion inhibits SARS-CoV-2 main protease and viral replication in vitro.” Chemical Communications 57, no. 78 (2021): 10083-10086. https://doi.org/10.1039/D1CC03563K