Group Leader, Emory Vaccine Program
International Centre for Genetic Engineering and Biotechnology
Aruna Asaf Ali Marg
110 067 New Delhi, India
E-mail: [email protected]
Tel: +91-11-26741358 ext. 180 or 181
Education
National Center for Cell Science, India, PhD
Yale University, Postdoc
Scientific Activity
2020: Associate Professor, ICGEB-EMORY Vaccine Program, ICGEB, New Delhi, India
2012:Assistant Professor, ICGEB-EMORY Vaccine Program, ICGEB New Delhi, India
2009: Research Scientist, EMORY Vaccine Centre
By training young scientists in setting up state of the art immunology tools and techniques (eg high throughput human monoclonal antibody production, single cell sorting, MHC tetramer technology, T cell epitope mapping, single cell intracellular cytokine assays, and somatic hypermutation analysis) in the lab at ICGEB, the goals of the ongoing research are to gain an in-depth understanding of human immunity dengue and chikungunya virus infections.
1. Using systems biology to define the molecular signatures of innate and adaptive immune responses during dengue and chikungunya infection.
2. To determine whether IgG Fc glycan composition is a determinant of antibody functionality and its impact on pathogenesis of disease.
3. To characterize the human B cell response during dengue and chikungunya infection – their functionality, specificity, isotype usage and affinity maturation.
4. To phenotypically and functionally characterize CD4 and CD8 T cell responses in dengue and chikungunya patients.
5. To generate human monoclonal antibodies that may provide novel avenues towards dengue and chikungunya therapeutics.
Selected publications
Anmol Chandele: https://www.ncbi.nlm.nih.gov/pubmed/?term=Chandele+A
Chandele, A., Sewatanon, J., Gunisetty, S., Singla, M., Onlamoon, N., Akondy, R.S., Kissick, H.T., Nayak, K., Reddy, E.S., Kalam, H., Kumar, D., Verma, A., Panda, H., Wang, S., Angkasekwinai, N., Pattanapanyasat, K., Chokephaibulkit, K., Medigeshi, G.R., Lodha, R., Kabra, S., Ahmed, R., Murali-Krishna, K. 2016. Characterization of Human CD8 T Cell Responses in Dengue Virus-Infected Patients from India. J Virol 90, 11259-11278 PubMed link
Carpenter, C., Sidney, J., Kolla, R., Nayak, K., Tomiyama, H., Tomiyama, C., Padilla, O.A., Rozot, V., Ahamed, S.F., Ponte, C., Rolla, V., Antas, P.R., Chandele, A., Kenneth, J., Laxmi, S., Makgotlho, E., Vanini, V., Ippolito, G., Kazanova, A.S., Panteleev, A.V., Hanekom, W., Mayanja-Kizza, H., Lewinsohn, D., Saito, M., McElrath, M.J., Boom, W.H., Goletti, D., Gilman, R., Lyadova, I.V., Scriba, T.J., Kallas, E.G., Murali-Krishna, K., Sette, A., Lindestam Arlehamn, C.S. 2015. A side-by-side comparison of T cell reactivity to fifty-nine Mycobacterium tuberculosis antigens in diverse populations from five continents. Tuberculosis (Edinb). 95, 713-21. PubMed link
Nayak, K., Jing, L., Russell, R.M., Davies, D.H., Hermanson, G., Molina, D.M., Liang, X., Sherman, D.R., Kwok, W.W., Yang, J., Kenneth, J., Ahamed, S.F., Chandele, A., Murali-Krishna, K., Koelle, D.M. 2015. Identification of novel Mycobacterium tuberculosis CD4 T-cell antigens via high throughput proteome screening. Tuberculosis (Edinb) 95, 275-87 PubMed linkKulkarni RR, Rasheed MA, Bhaumik SK, Ranjan P, Cao W, Davis C, Marisetti K, Thomas S, Gangappa S, Sambhara S, Murali-Krishna K. 2014. Activation of the RIG-I pathway during influenza vaccination enhances the germinal center reaction, promotes T follicular helper cell induction, and provides a dose-sparing effect and protective immunity. J Virol. 88:13990-4001 PubMed Link
Kulkarni RR, Rasheed MA, Bhaumik SK, Ranjan P, Cao W, Davis C, Marisetti K, Thomas S, Gangappa S, Sambhara S, Murali-Krishna K. 2014. Activation of the RIG-I pathway during influenza vaccination enhances the germinal center reaction, promotes T follicular helper cell induction, and provides a dose-sparing effect and protective immunity. J Virol. 88:13990-4001 PubMed Link
Wrammert, J., Murali-Krishna, K. 2014. Cellular screens to interrogate the human T and B cell repertoires and design better vaccines. Vaccine design
Wrammert J, Onlamoon N, Akondy RS, Perng GC, Polsrila K, Chandele A, Kwissa M, Pulendran B, Wilson PC, Wittawatmongkol O, Yoksan S, Angkasekwinai N, Pattanapanyasat K, Chokephaibulkit K, Ahmed R. 2012. Rapid and massive virus-specific plasmablast responses during acute dengue virus infection in humans. J Virol. 86: 2911-2918 PubMed link
Marshall, H.D., Chandele, A., Jung, Y.W., Meng, H., Poholek, A.C., Parish, I.A., Rutishauser, R., Cui, W., Kleinstein, S.H., Craft, J., Kaech, S.M. 2011.Differential expression of Ly6C and T-bet distinguish effector and memory Th1 CD4(+) cell properties during viral infection. Immunity 35, 633-646 PubMed link
Chandele, A., Mukerjee, P., Das, G., Ahmed, R., Chauhan, V.S. 2011. Phenotypic and functional profiling of malaria-induced CD8 and CD4 T cells during blood-stage infection with Plasmodium yoelii. Immunology. 2011 132, 273-286 PubMed link