Alessandro Vindigni

Wednesday, 2 May 2018| 3:00 pm

Edward A. Doisy  Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, St. Louis, MO, USA

Mechanisms of replication stress response to chemotherapeutics

(Host: A. Muro)

Aberrant DNA replication is one of the leading causes of mutations and chromosome re arrangements associated with several cancer related pathologies.At the same time, agents that stall or damage DNA replication forks are widely used for chemotherapy, in the attempt to selectively target highly proliferating cancer cells.

We showed that replication forkreversal is a pivotal mechanism of replication stress response to chemotherapeutics that allows cancer cells to withstand DNA damaging chemotherapy.Our recent progress toward the understanding of factors involved in the formation and protection of reversed replication works will be discussed. Thesestudies provide important clues on enzymes that can be targeted to prevent fork reversal and increase chemotherapy sensitivity.