Our Projects

The ICGEB research groups participate in many calls for proposals on topics relevant to their fields of interest and are supported by a vast array of donors: from Governmental bodies to private companies, and charities. The major ongoing projects are shown here, divided under the Sustainable Development Goals that ICGEB strives to address. 

zero hunger

Editing rice genes through CRISPR/Cas9 technology for enhanced and durable blast resistance in rice

Donor

Department of Biotechnology (DBT), Government of India

ICGEB Crop Improvement Group New Delhi, M. K. Reddy

Duration: 2020-2022

Re-designing rice crops for improved grain micronutrient quality using CRISPR-Cas9/Cpf1 genome editing

Donor
Indian Council of Medical Research (ICMR)

ICGEB Nutritional Improvement of Crops Group New Delhi, T. Kaul

Duration: 2019-2021

Develop bacterial biofertilizers for Coffea canephora (C.robusta)

Donor:
MAECI


ICGEB Bacteriology Lab Trieste, V. Venturi


Duration: 2021-2023

good health

INCardio

Donor
European Regional Development Fund and Interreg V-A Italy-Austria 2014-2020 

Partners
Eurac Research, Medical University of Innsbruck, Carinthia University of Applied Sciences

ICGEB Cardiovascular Biology Lab Trieste, S. Zacchigna


Duration: 2020-2022

Cardiomiciti di cellule staminali per una cardiologia personalizzata – CardioStem

Donor
Regione Autonoma Friuli Venezia Giulia (L.R. 17/2014)

Partners
Azienda Sanitaria Universitaria Integrata Trieste ASUITS (Struttura complessa di Cardiologia)


ICGEB Molecular Medicine Lab Trieste, M. Giacca


Duration: 2019-2021

The rolE of the matRix in cAncer protection: leSsons from the hEart and novel therapeutic opportunities – ERASE

Donor
AIRC Investigator Grant 2020


ICGEB Cardiovascular Biology Lab Trieste, S. Zacchigna


Duration: 2020-2026

Characterisation of the functions of the Human Papillomavirus E6 and E7 oncoproteins

Donor
AIRC investigator Grant 2019


ICGEB Tumour Virology Lab Trieste, L. Banks

Duration: 2020-2025

CARDIORiGen

Donor
Fondazione CRTrieste CARDIOGEN

Partners
Azienda Sanitaria Universitaria Integrata Trieste ASUITS (Struttura complessa di Cardiologia)


ICGEB Molecular Medicine Lab Trieste, M. Giacca

Duration: 2019-2022

cGAS-STING driven activation of type-I interferone in Wiskott-Aldrich syndrome

Donor
Fondazione Telethon

ICGEB Cellular Immunology Lab Trieste, F. Benvenuti

Duration: 2021-2024

Liver-directed promotierless gene targeting without the use of nucleases as a potential therapy for Fabry disease

Donor
Fondazione Telethon


ICGEB Mouse Molecular Genetics Lab Trieste, A. Muro

Duration: 2021-2024

Full-length RGNEF and/or “RGNEF leucine–rich domain” as a therapeutic target in ALS

Donor
Western Ontario University

ICGEB Molecular Pathology Lab Trieste, E. Buratti


Duration: 2019-2022

Structured-based approach to develop a novel mechanism-of-action antimalarial with multistage activity

Donor
The Broad Institute


ICGEB Emory Vaccine Program New Delhi, A. Chandele


Duration: 2020-2022

Pre-clinical validation of FDA-approved molecules able to rescue GAA pre-mRNAs plicing of c.-32-13T>G mutants as therapeutic agents for late- onset Pompe Disease

Donor
Acid Maltase Deficiency Association – AMDA

Partners
Azienda Sanitaria Universitaria Integrata di Udine ASUIUD (University Hospital “Santa Maria della Misericordia”)


ICGEB Molecular Pathology Lab Trieste, E. Buratti

Duration: 2019-2022

Development of dipeptide based targeted nanoformulation for breast cancer

Donor
Genethon

Mouse Molecular Genetics Lab Trieste, A. Muro

Duration: 2020-2022

Evoluzione di SARS-CoV-2 e analisi della risposta cellulare all’infezione nell’ambito del Sistema ARGO

Donor
AREA Science Park


ICGEB Molecular Virology Lab Trieste, A. Marcello

Duration: 2020-2022

Epigenetic cross-talks and novel therapeutic strategies to prevent disease progression in ERG fusion positive prostate cancer

Donor
National Research Foundation – South Africa/SWISS Joint Research Cooperation Programme

Partners
Univ. Bern, Inst. Oncology Research, Bellinzona

ICGEB Cancer Genomics Lab Cape Town, L. Zerbini


Duration: 2017-2020

Regulation of host splicing machinery by factors from mycobacterium tuberculosis and its impact on host innate defense mechanism

Donor
Wellcome Trust Alliance

ICGEB Cellular Immunology Lab New Delhi, D. Kumar


Duration: 2018-2022

A novel exon-specific U1 snRNA strategy to correct splicing in Familial Dysautonomia

Donor
National Eye Institute of the National Institutes of Health

Partner

Massachusetts General Hospital

ICGEB Human Molecular Genetics Lab Trieste, F. Pagani


Duration: 2018-2022

Biomolecular characterisation of Malaria parasite drug target dihydropteroate synthase

Donor
Department of Science and Technology (DST), Government of India

ICGEB Structural Parasitology Lab New Delhi, A. Sharma


Duration: 2018-2021

A Phase I, clinical trial to assess the safety and immunogenicity of P. falciparum vaccines

Donor

Biotechnology Industry Research Assistance Council (BIRAC)

Partner

Syngene International Ltd

ICGEB New Delhi, V.S. Chauhan
Duration: 2018-2020

Evolution and transmission of drug resistant tuberculosis in Agartala, Kohima and Imphal population

Donor

Department of Biotechnology (DBT), Government of India

Partners

Manipur Univ., Jawaharlal Nehru Inst. Medical Sciences, Naga Hospital Authority, Agartala Gov. Med. College

ICGEB Translational Health Lab New Delhi, R. Nanda

Duration: 2018-2021

Translational research and clinical development of malaria vaccine candidates

Donor

Department of Biotechnology (DBT), Government of India

ICGEB New Delhi, V.S. Chauhan

Duration: 2019-2022

Synthetic biology approach for producing artemisinin in edible plant and effective Malaria treatment by oral delivery of plant cells

Donor
Department of Biotechnology (DBT), Government of India

ICGEB Metabolic Engineering Lab New Delhi, S. Kumar

Duration: 2018-2021


Functional delineation of viral encoded RNAi suppressor on plant miRNA pathways

Donor
Department of Biotechnology (DBT), Government of India

ICGEB Transcription Regulation Group New Delhi, N. Sarovar Bhavesh

Duration: 2018-2021

Genomics-driven dissection of susceptibility geographical focus on NER

Donor
Department of Biotechnology (DBT), Government of India

Partners
National Inst. Biomed. Genomics, Foundation Neglected Disease Res., Mizoram University, Dpt. Health & Family Welfare

ICGEB Cellular Immunology Lab New Delhi, D. Kumar

Duration: 2018-2021

Development of a chikungunya candidate vaccine in vesicular stomatitis virus (VSV) gene delivery platform

Donor
Department of Biotechnology (DBT), Government of India

ICGEB Vector-Borne Diseases Lab New Delhi, S. Sunil


Duration: 2019-2022


Comprehensive omics studies to understand the biology of drug resistant Mycobacterium tuberculosis clinical isolates from Arunachal Pradesh

Donor
Department of Biotechnology (DBT), Government of India

ICGEB Parasite Cell Biology Lab New Delhi, A. Mohmmed

Duration: 2019-2022

Human B Cell responses and receptor repertoire in dengue patients from India

Donor
Department of Biotechnology (DBT), Government of India

ICGEB EMORY-ICGEB Vaccine Program, A. Chandele

Duration: 2019-2021

Hit to lead development of potent anti-parasitic natural product scaffolds

Donor
Department of Science and Technology (DST), Government of India

ICGEB Structural Parasitology Lab New Delhi, A. Sharma

Duration: 2019-2022

Membrane biogenesis in Apicomplexa parasites: trafficking and recycling lipid sources for membrane remodelling as drug targets against malaria and toxoplasmosis

Donor
Indo-French Centre for Promotion of Advanced Research

ICGEB Parasite Cell Biology Lab New Delhi, A. Mohmmed

Duration: 2019-2022

Translational Research Consortia for establishing platform technologies to support prophylactic and therapeutic strategies for Dengue discovey to proof of concept

Donor
Biotechnology Industry Research Assistance Council (BIRAC)

ICGEB EMORY Vaccine Program, A. Chandele

Duration: 2019-2023

Translational research consortia TRC for Chikungunya virus

Donor
Biotechnology Industry Research Assistance Council (BIRAC)

ICGEB Vector-Borne Diseases Lab New Delhi, S. Sunil

Duration: 2019-2023

Structure determination and targeting of ubiquitously expressed membrane integrated form of chloride intracellular channels (CLICs) for discovery of small molecular anti-cancer therapeutics

Donor
Department of Biotechnology (DBT), Government of India

ICGEB Membrane Protein Biology Lab New Delhi, A. Arulandu

Duration: 2019-2022

Targeting drug resistance in tuberculosis and malaria

Donor
Department of Biotechnology (DBT), Government of India

ICGEB Structural Immunology Lab New Delhi, D. Salunke

Duration: 2019-2022


EMBO symposium titled Mycobacterial heterogeneity and host tissue tropism

Donor

EMBO

ICGEB Cellular Immunology Lab New Delhi, D. Kumar


Duration: 2020

Design, validation and development of novel peptidomimetic

Donor

Department of Science and Technology (DST), Government of India

ICGEB Membrane Protein Biology Lab New Delhi, A. Arulandu


Duration: 2020-2022

In vivo models to study the role of genetic lesions and microenvironmental signals in driving CLL cell proliferation

Donor

AIRC Investigator Grant 2020

ICGEB Molecular Hematology Lab Trieste, D. Efremov

Duration: 2021-2025

Metastatic disease: the key to unmet need in oncology – 5 per mille 2019

Donor

AIRC Investigator Grant 2020

ICGEB Cancer Cell Signalling Trieste, G. Del Sal


Duration: 2019-2026

Defining the role of hnRNP proteins in enhancing TDP-43 pathology – PathensTDP

Donor

AriSLA

ICGEB Molecular Pathology Lab Trieste, E. Buratti

Duration: 2019-2022

Identificazione di Coronavirus SARS-CoV-2 e definizione della risposta cellulare innata ed adattiva

Donor

Assicurazioni GENERALI

ICGEB Molecular Virology Lab Trieste, A. Marcello

Duration: 2020-2022

COVID-19: Establishing rapid laboratory diagnostics programs in LMICs

Donor

Bill&Melinda Gates Foundation

Partners

New England Biolabs, Chantal Biya Int. Reference Centre in Cameroon, Ethiopian Biotech Institute (EBTi), Kenya Medical Research Institute – KEMRI, College of Medical Sciences, University of Maiduguri, Department of Medical Laboratory Science – Nigeria

ICGEB Molecular Virology Lab Trieste, A. Marcello


Duration: 2020-2021

Development of dipeptide based targeted nanoformulation for breast cancer

Donor

Biotechnology Industry Research Assistance Council (BIRAC)


ICGEB New Delhi, V. S. Chauhan

Duration: 2020-2022

Renovation and daily running of BL3 Laboratory

Donor

Beneficentia Stiftung

ICGEB Molecular Virology Lab Trieste, A. Marcello

Duration: 2020-2022

CureCN

Donor

Genethon

Mouse Molecular Genetics Lab Trieste, A. Muro

Duration: 2018-2022

Exploiting diversity oriented chemical synthesis for combating chronic parasitic infection

Donor

National Institutes of Health

ICGEB Structural Parasitology Lab New Delhi, A. Sharma


Duration: 2020-2023

Professional Development Programme

Donor

National Research Foundation
South Africa/SWISS Joint Research Cooperation Programme


ICGEB Cancer Genomics Lab Cape Town, L. Zerbini

Duration: 2020-2022

Regenerative strategies for heart disease via targeting the long noncoding transcriptome – SINERGIA

Donor

Swiss National Fund

Partner

University of Lausanne Medical School

ICGEB Molecular Medicine Lab Trieste, M. Giacca

Duration: 2017-2021

PREFER

Donor

POR FESR 2014-2020

Partners

Vivabiocell, Zeta Research, Università degli Studi di Trieste

ICGEB Cardiovascular Biology Lab Trieste, S. Zacchigna

Duration: 2018-2022

Dengue Vaccine Programme

Donor

SunPharma International

ICGEB Translational Health Group New Delhi, N. Khanna

Duration:2016-2021

quality education

ComUnicaRe per crescere In SAlute-Curiosa

Donor
Regione Autonoma Friuli Venezia Giulia, L.R. 17/2014

Partner
University of Trieste (Dipartimento di Scienze Mediche e Chirurgiche e della Salute)

ICGEB Cardiovascular Biology Lab Trieste, S. Zacchigna

Duration: 2019-2022

Organizing an International summit on women in STEM

Donor

Department of Biotechnology (DBT), Government of India

ICGEB Structural Immunology Lab New Delhi, D. Salunke

Duration: 2020

affordable energy

Development of Paenibacillus polymyxa as a platform for production of branched chain alcohols

Donor
Department of Biotechnology (DBT), Government of India

ICGEB Microbial Engineering Lab New Delhi, S. Yazdani

Duration: 2019-2022

Reducing industrial waste from sugar cane processing in India

Donor
Department of Biotechnology (DBT), Government of India

Partner
University of York (UK), University of Leon (Spain), Jesmond Engineering Ltd (UK)

ICGEB Microbial Engineering Lab New Delhi, S. Yazdani

Duration: 2018-2021

Demonstration of algal chassis for the photo autotrophic production of isoprenoids

Donor
Department of Biotechnology (DBT), Government of India

ICGEB Omics of Algae Lab New Delhi, P. Jutur

Duration: 2019-2022

Indian Marine cyanobacterial host for production of drop-in fuels

Donor
Department of Biotechnology (DBT), Government of India

ICGEB Microbial Engineering Lab New Delhi, S. Yazdani

Duration: 2019-2022

Genetic engineering of microalgae for producing alkanes for further applications

Donor
Department of Biotechnology (DBT), Government of India

ICGEB Metabolic Engineering Lab New Delhi, S. Kumar Rhode and N. Gaur

Duration: 2020-2022

Psilocybin producing S. cerevisiae strain with the yield of 1000 mg/L in laboratory scale fermenter (500ml)

Donor

Nirvana Life Science Inc.

ICGEB Yeast Biofuel Lab New Delhi, N. Gaur

Duration: 2020-2021

Carbonaceous gas to fuel by genetically engineered organisms

Donor
TATA STEEL LIMITED

ICGEB Microbial Engineering Lab New Delhi, S. Yazdani

Duration: 2019-2022

industry innovation

UNEP-GED Project for sustainable Capacity Building for Effective Participation in the BCH in Italy

Donor

UNEP

ICGEB Regulatory Science, Trieste, W. Craig


Duration: 2020-2021

partnership for the goals

CUTTiNG 2020

Donor

Ministero dello Sviluppo Economico, Governo Italiano

ICGEB Fundraising TT & Innovation, M. Viviani


Duration: 2020-2023