Our Projects

The ICGEB research groups participate in many calls for proposals on topics relevant to their fields of interest and are supported by a vast array of donors: from Governmental bodies to private companies, and charities. The major ongoing projects are shown here, divided under the Sustainable Development Goals that ICGEB strives to address in particular through its Strategic Framework, while cross-cutting actions also cover SDG5, SDG12, SDG13 and SDG15.

zero hunger

Donor

Department of Biotechnology (DBT), Government of India

Editing rice genes through CRISPR/Cas9 technology for enhanced and durable blast resistance in rice

ICGEB Crop Improvement Group New Delhi, M. K. Reddy

Duration: 2020-2022

Donor
Indian Council of Medical Research (ICMR)

Re-designing rice crops for improved grain micronutrient quality using CRISPR-Cas9/Cpf1 genome editing

ICGEB Nutritional Improvement of Crops Group New Delhi, T. Kaul

Duration: 2019-2021

Donor
Ministry of Foreign Affairs and International Cooperation (MAECI), Government of Italy

Developing bacterial biofertilizers for Coffea canephora (C. robusta)

ICGEB Bacteriology Lab Trieste, V. Venturi

Duration: 2021-2023

Donor
Standards and Trade Development Facility

Enhancing trade through regulatory harmonisation and biopesticide-based residue mitigation in the SADC region

ICGEB Biopesticides Group

Cape Town, D. Ndolo

Duration: 2021-2024

Donor
South Africa National Research Foundation

Biocontrol options for fall armyworm control in Southern Africa

ICGEB Biopesticides Group

Cape Town, D. Ndolo

Duration: 2019 – 2022

good health

Donor
Acid Maltase Deficiency Association – AMDA

Pre-clinical validation of FDA-approved molecules able to rescue GAA pre-mRNAs plicing of c.-32-13T>G mutants as therapeutic agents for late- onset Pompe Disease

Partners
Azienda Sanitaria Universitaria Integrata di Udine ASUIUD (University Hospital “Santa Maria della Misericordia”)


ICGEB Molecular Pathology Lab Trieste, E. Buratti

Duration: 2019-2022

Donor
AIRC Investigator Grant 2020

Metastatic disease: the key to unmet need in oncology – 5 per mille 2019

ICGEB Cancer Cell Signalling Trieste, G. Del Sal


Duration: 2019-2026

Donor
AIRC Investigator Grant 2020

The rolE of the matRix in cAncer protection: leSsons from the hEart and novel therapeutic opportunities – ERASE

ICGEB Cardiovascular Biology Lab Trieste, S. Zacchigna


Duration: 2020-2026

Donor
AIRC Investigator Grant 2020

In vivo models to study the role of genetic lesions and microenvironmental signals in driving CLL cell proliferation

ICGEB Molecular Hematology Lab Trieste, D. Efremov

Duration: 2021-2025

Donor
AIRC Investigator Grant 2019

Characterisation of the functions of the Human Papillomavirus E6 and E7 oncoproteins

ICGEB Tumour Virology Lab Trieste, L. Banks

Duration: 2020-2025

Donor
AriSLA

Defining the role of hnRNP proteins in enhancing TDP-43 pathology – PathensTDP

ICGEB Molecular Pathology Lab Trieste, E. Buratti


Duration: 2019-2022

Donor
Assicurazioni GENERALI

Identificazione di Coronavirus SARS-CoV-2 e definizione della risposta cellulare innata ed adattiva

ICGEB Molecular Virology Lab Trieste, A. Marcello


Duration: 2020-2022

Donor
Beneficentia Stiftung

Renovation and daily running of BL3 Laboratory

ICGEB Molecular Virology Lab Trieste, A. Marcello


Duration: 2020-2022

Donor
Bill&Melinda Gates Foundation

COVID-19: Establishing rapid laboratory diagnostics programs in LMICs

Partners

New England Biolabs, Chantal Biya Int. Reference Centre in Cameroon, Ethiopian Biotech Institute (EBTi), Kenya Medical Research Institute – KEMRI, College of Medical Sciences, University of Maiduguri, Department of Medical Laboratory Science – Nigeria

ICGEB Molecular Virology Lab Trieste, A. Marcello


Duration: 2020-2021

Donor
Bill&Melinda Gates Foundation

COVID-19: Community Access Diagnostics laboratory networks

Partners

New England Biolabs, LabGene, IRSS Bobo-Dioulasso (Burkina Faso), Chantal Biya Int. Reference Centre, Ethiopian Biotech Institute (EBTi), Pasteur Institut Abidjan, Kenya Medical Research Institute – KEMRI, University of Maiduguri Teaching Hospital, Institute for Research, Epidemiological Surveillance and Training (IRESSEF), National Institute for Tropical Disease (Sudan), National Microbiology Reference Laboratory – NMRL (Burkina Faso)


Duration: 2021-2023

Donor
Biotechnology Industry Research Assistance Council (BIRAC)

Translational research consortia TRC for Chikungunya virus

ICGEB Vector-Borne Diseases Lab New Delhi, S. Sunil


Duration: 2019-2023

Donor
Biotechnology Industry Research Assistance Council (BIRAC)

Translational Research Consortia for establishing platform technologies to support prophylactic and therapeutic strategies for Dengue discovey to proof of concept

ICGEB EMORY Vaccine Program, A. Chandele


Duration: 2019-2023

Donor
Biotechnology Industry Research Assistance Council (BIRAC)

Development of dipeptide based targeted nanoformulation for breast cancer


ICGEB New Delhi, V. S. Chauhan

Duration: 2020-2022

Donor
Broad Institute

Structured-based approach to develop a novel mechanism-of-action antimalarial with multistage activity

ICGEB Emory Vaccine Program New Delhi, A. Chandele


Duration: 2020-2022

Donor
Department of Biotechnology (DBT), Government of India

Human B Cell responses and receptor repertoire in dengue patients from India

ICGEB EMORY-ICGEB Vaccine Program, A. Chandele

Duration: 2019-2021

Donor
Department of Biotechnology (DBT), Government of India

Translational research and clinical development of malaria vaccine candidates

ICGEB New Delhi, V.S. Chauhan


Duration: 2019-2022

Donor
Department of Biotechnology (DBT), Government of India

Structure determination and targeting of ubiquitously expressed membrane integrated form of chloride intracellular channels (CLICs) for discovery of small molecular anti-cancer therapeutics

ICGEB Membrane Protein Biology Lab New Delhi, A. Arulandu


Duration: 2019-2022

Donor
Department of Biotechnology (DBT), Government of India

Gene editing of key plasmodium transporters and lipid metabolism enzymes to decipher parasite drug resistance mechanisms

ICGEB Malaria Biology Lab New Delhi, P. Malhotra

Duration: 2018-2022

Donor
Department of Biotechnology (DBT), Government of India

Targeting drug resistance in tuberculosis and malaria

ICGEB Structural Immunology Lab New Delhi, D. Salunke


Duration: 2019-2022

Donor
Department of Biotechnology (DBT), Government of India

Comprehensive omics studies to understand the biology of drug resistant Mycobacterium tuberculosis clinical isolates from Arunachal Pradesh

ICGEB Parasite Cell Biology Lab New Delhi, A. Mohmmed


Duration: 2019-2022

Donor
Department of Biotechnology (DBT), Government of India

Genomics-driven dissection of susceptibility geographical focus on NER

Partners
National Inst. Biomed. Genomics, Foundation Neglected Disease Res., Mizoram University, Dpt. Health & Family Welfare

ICGEB Cellular Immunology Lab New Delhi, D. Kumar

Duration: 2018-2021

Donor
Department of Biotechnology (DBT), Government of India

Development of a chikungunya candidate vaccine in vesicular stomatitis virus (VSV) gene delivery platform

ICGEB Vector-Borne Diseases Lab New Delhi, S. Sunil


Duration: 2019-2022

Donor
Department of Biotechnology (DBT), Government of India

Synthetic biology approach for producing artemisinin in edible plant and effective Malaria treatment by oral delivery of plant cells

ICGEB Metabolic Engineering Lab New Delhi, S. Kumar

Duration: 2018-2021

Donor
Department of Biotechnology (DBT), Government of India

Evolution and transmission of drug resistant tuberculosis in Agartala, Kohima and Imphal population

Partners
Manipur Univ., Jawaharlal Nehru Inst. Medical Sciences, Naga Hospital Authority, Agartala Gov. Med. College

ICGEB Translational Health Lab New Delhi, R. Nanda

Duration: 2018-2021

Donor
Department of Biotechnology (DBT), Government of India

Functional delineation of viral encoded RNAi suppressor on plant miRNA pathways

ICGEB Transcription Regulation Group New Delhi, N. Sarovar Bhavesh


Duration: 2018-2021

Donor
Department of Biotechnology (DBT), Government of India

Developing double herbicide tolerant pigeonpen for improved weed management employing two pronged  approach: haplotype mining in native germplasm and CRISPR/Cas9 memdiated genome editing tool

ICGEB Nutritional Improvement of Crops Lab New Delhi, T. Kaul

Duration: 2021-2024

Donor
Department of Science and Technology (DST), Government of India

Design, validation and development of novel peptidomimetic

ICGEB Membrane Protein Biology Lab New Delhi, A. Arulandu

Duration: 2020-2022

Donor
Department of Science and Technology (DST), Government of India

Hit to lead development of potent anti-parasitic natural product scaffolds

ICGEB Structural Parasitology Lab New Delhi, A. Sharma


Duration: 2019-2022

Donor
Department of Science and Technology (DST), Government of India

Biomolecular characterisation of Malaria parasite drug target dihydropteroate synthase

ICGEB Structural Parasitology Lab New Delhi, A. Sharma


Duration: 2018-2021

Donor
European Regional Development Fund and Interreg V-A Italy-Austria 2014-2020 

INCardio

Partners
Eurac Research, Medical University of Innsbruck, Carinthia University of Applied Sciences

ICGEB Cardiovascular Biology Lab Trieste, S. Zacchigna


Duration: 2020-2022

Donor
Fondazione CRTrieste CARDIOGEN

CARDIORiGen

Partners
Azienda Sanitaria Universitaria Integrata Trieste ASUITS (Struttura complessa di Cardiologia)


ICGEB Molecular Medicine Lab Trieste, M. Giacca


Duration: 2019-2022

Donor
Fondazione Telethon

cGAS-STING driven activation of type-I interferone in Wiskott-Aldrich syndrome

ICGEB Cellular Immunology Lab Trieste, F. Benvenuti


Duration: 2021-2024

Donor
Fondazione Telethon

Liver-directed promotierless gene targeting without the use of nucleases as a potential therapy for Fabry disease

ICGEB Mouse Molecular Genetics Lab Trieste, A. Muro


Duration: 2021-2024

Donor
Genethon

Adeno-Associated Virus Vector-Mediated Liver Gene Therapy for Crigler-Najjar Syndrome WP5

Mouse Molecular Genetics Lab Trieste, A. Muro


Duration: 2018-2022

Donor
Genethon

Adeno-Associated Virus Vector-Mediated Liver Gene Therapy for Crigler-Najjar Syndrome CureCN

Mouse Molecular Genetics Lab Trieste, A. Muro


Duration: 2018-2022

Donor
Indian Council of Medical Research

Human Monoclonals to COVID-19

ICGEB-EMORY Vaccine Program New Delhi, A. Chandele


Duration: 2020-2021

Donor
Indo-French Centre for Promotion of Advanced Research

Membrane biogenesis in Apicomplexa parasites: trafficking and recycling lipid sources for membrane remodelling as drug targets against malaria and toxoplasmosis

ICGEB Parasite Cell Biology Lab New Delhi, A. Mohmmed


Duration: 2019-2022

Donor
Ministry of Health, Government of Italy

VLA-4 IN CLL (RF Ministero Salute)

Partner

CRO Aviano

ICGEB Molecular Hematology Lab Trieste, D. Efremov


Duration: 2018-2021

Donor
National Eye Institute of the National Institutes of Health

A novel exon-specific U1 snRNA strategy to correct splicing in Familial Dysautonomia

Partner
Massachusetts General Hospital

ICGEB Human Molecular Genetics Lab Trieste, F. Pagani


Duration: 2018-2022

Donor
National Institutes of Health

Exploiting diversity oriented chemical synthesis for combating chronic parasitic infection

ICGEB Structural Parasitology Lab New Delhi, A. Sharma


Duration: 2020-2023

Donor
National Research Foundation
South Africa

Epigenetic cross-talks and novel therapuetic strategies to prevent disease progression in ERG fusion positive prostrate cancer

ICGEB Cancer Genomics Lab Cape Town, L. Zerbini


Duration: 2017-2021

Donor
National Research Foundation
South Africa/SWISS Joint Research Cooperation Programme

Professional Development Programme


ICGEB Cancer Genomics Lab Cape Town, L. Zerbini

Duration: 2020-2022

Donor
Regione Autonoma Friuli Venezia Giulia – POR FESR

PREFER

Partners
Vivabiocell, Zeta Research, Università degli Studi di Trieste

ICGEB Cardiovascular Biology Lab Trieste, S. Zacchigna


Duration: 2018-2022

Donor
Regione Autonoma Friuli Venezia Giulia (L.R. 17/2014)

Cardiomiciti di cellule staminali per una cardiologia personalizzata – CardioStem

Partners
Azienda Sanitaria Universitaria Integrata Trieste ASUITS (Struttura complessa di Cardiologia)

ICGEB Molecular Medicine Lab Trieste, M. Giacca


Duration: 2019-2021

Donor
SunPharma International

Dengue Vaccine Programme

ICGEB Translational Health Group New Delhi, N. Khanna


Duration: 2016-2021

Donor
SPI Pharma

Dengue Vaccine Programme

ICGEB Recombinant Gene Products Lab New Delhi, N. Khanna


Duration: 2016-2021

Donor
Swiss National Fund

Regenerative strategies for heart disease via targeting the long noncoding transcriptome – SINERGIA

Partner
University of Lausanne Medical School

ICGEB Molecular Medicine Lab Trieste, M. Giacca


Duration: 2017-2021

Donor
Wellcome Trust Alliance

Regulation of host splicing machinery by factors from mycobacterium tuberculosis and its impact on host innate defense mechanism

ICGEB Cellular Immunology Lab New Delhi, D. Kumar


Duration: 2018-2022

Donor
Western Ontario University

Full-length RGNEF and/or “RGNEF leucine–rich domain” as a therapeutic target in ALS

ICGEB Molecular Pathology Lab Trieste, E. Buratti


Duration: 2019-2022

quality education

Donor
Department of Biotechnology (DBT), Government of India

Organizing an International summit on women in STEM

ICGEB Structural Immunology Lab New Delhi, D. Salunke

Duration: 2020-2021

Donor
Elettra-Sincrotrone

Support for A. Falaschi fellows from developing coutries in biology, biophysics, life sciences and biotechnology

ICGEB Research Grants – CRP and Fellowships, Trieste

Duration: 2021-2024

Donor
Italian Agency for Development Cooperation (AICS)

BIOTECHNET – Enhancing biotechnology know-how in the Horn of Africa (AID n.12098)

Duration: 2021-2024

Donor
Ministry of Foreign Affairs and International Cooperation (MAECI), Government of Italy

WE-STAR – PhD and Postdoctoral training scheme for Women Scientists in Africa

Duration: 2021-2022

Donor
Ministry of University and Research (MUR), Government of Italy

Science & the City: da Trieste a Padova, Bergamo e Napoli, ICGEB porta la scienza in piazza

ICGEB Communications, Public Information & Outreach Trieste, S. Kerbavcic

Duration: 2021-2022

Donor
Regione Autonoma Friuli Venezia Giulia, L.R. 17/2014

ComUnicaRe per crescere In SAlute-CURIoSA

Partner
University of Trieste (Dipartimento di Scienze Mediche e Chirurgiche e della Salute)

ICGEB Cardiovascular Biology Lab Trieste, S. Zacchigna

Duration: 2019-2022

Donor
United Nations Office for South-South Cooperation (UNOSSC)

EMPOWERing participation of Women Scientists from the Global South in Science Technology and Innovation

Duration: 2021-2022

Donor
Wellcome Trust Alliance

Early-Career fellowship programme

ICGEB Emory-Vaccine Programme New Delhi, A. Chandele


Duration: 2020-2025

affordable energy

Donor
Department of Biotechnology (DBT), Government of India

Genetic engineering of microalgae for producing alkanes for further applications

ICGEB Metabolic Engineering Lab New Delhi, S. Kumar Rhode and N. Gaur

Duration: 2020-2022

Donor
Department of Biotechnology (DBT), Government of India

Demonstration of algal chassis for the photo autotrophic production of isoprenoids

ICGEB Omics of Algae Lab New Delhi, P. Jutur

Duration: 2019-2022

Donor
Department of Biotechnology (DBT), Government of India

Indian Marine cyanobacterial host for production of drop-in fuels

ICGEB Microbial Engineering Lab New Delhi, S. Yazdani

Duration: 2019-2022

Donor
Department of Biotechnology (DBT), Government of India

Development of Paenibacillus polymyxa as a platform for production of branched chain alcohols

ICGEB Microbial Engineering Lab New Delhi, S. Yazdani

Duration: 2019-2022

Donor
Department of Biotechnology (DBT), Government of India

Reducing industrial waste from sugar cane processing in India

Partners
University of York (UK), University of Leon (Spain), Jesmond Engineering Ltd (UK)

ICGEB Microbial Engineering Lab New Delhi, S. Yazdani

Duration: 2018-2021

Donor
Nirvana Life Science Inc.

Psilocybin producing S. cerevisiae strain with the yield of 1000 mg/L in laboratory scale fermenter (500ml)

ICGEB Yeast Biofuel Lab New Delhi, N. Gaur

Duration: 2020-2021

Donor
TATA STEEL LIMITED

Carbonaceous gas to fuel by genetically engineered organisms

ICGEB Microbial Engineering Lab New Delhi, S. Yazdani

Duration: 2019-2022

industry innovation

Donor
Fondazione Cariplo

Unravelling the innate immune response towards SARS-CoV2 (INNATE-CoV)

Partners

Fondazione Istituto Nazionale di Genetica Molecolare, Università degli Studi di MIlano – Bicocca

ICGEB Molecular Virology Lab Trieste, A. Marcello


Duration: 2020-2022

Donor
UNEP, GEF

SSFA/2020/3530 under “UNEP-GEF Project for Sustainable Capacity Building for Effective Participation in the BCH III”

ICGEB Regulatory Science, Trieste, W. Craig


Duration: 2020-2022

climate action

Promoting biopesticides: a sustainable pest control strategy for climate change adaptation

Donor

South Africa National Research Foundation

ICGEB Biopesticides Lab Cape Town, D. Ndolo

Duration: 2021-2023

partnership for the goals

CUTTiNG 2020

Donor

Ministry of Economic Development, Government of Italy

ICGEB Fundraising TT & Innovation
Duration: 2020-2023

Scientific Cooperation Programme

Donor

COMSTECH

ICGEB

Duration: 2022