Selected references on transcriptional regulation in P450-containing systems

Last modified: Wed Apr 14 09:45:54 BST 2004

• Badger, T.M., Huang, J., Ronis, M. and Lumpkin, C.K. (1993) Induction of cytochrome P450 2E1 during chronic ethanol exposure occurs via transcription of the CYP 2E1 gene when blood alcohol concentrations are high. Biochem. Biophys. Res. Commun. 190, 780-785.
• Barnes, H.J. (1996) Maximizing expression of eukaryotic cytochrome P450s in Escherichia coli. Methods Enzymol. 272, 3-14.
• Berndtson, A.K. and Chen, T.T. (1994) Two unique CYP1 genes are expressed in response to 3-methylcholanthrene treatment in rainbow trout. Arch. Biochem. Biophys. 310, 187-195.
• Boucher, P.D., Ruch, R.J. and Hines, R.N. (1993) Specific nuclear protein binding to a negative regulatory element on the human CYP1A1 gene. J. Biol. Chem. 268, 17384-17391.
• Brenza, H.L., Kimmel-Jehan, C., Jehan, F., Shinki, T., Anazawa, H., Suda, T. and DeLuca, H.F. (1998) Parathyroid hormone activation of the 25-hydroxyvitamin D₃-1-hydroxylase gene promoter. Proc. Natl. Acad. Sci. 95, 1387-1391.
• Cairns, W., Smith, C.A.D., McLaren, A.W. and Wolf, C.R. (1996) Characterization of the human cytochrome P4502D6 promoter. A potential role for antagonistic interactions between members of the nuclear receptor family. J. Biol. Chem. 271, 25269-25276.
• Celander, M., Hahn, M.E. and Stegeman, J.J. (1996) Cytochromes P450 (CYP) in the Poeciliopsis lucida hepatocellular carcinoma cell line (PLHC-1): dose- and time-dependent glucocorticoid potentiation of CYP1A induction without induction of CYP3A. Arch. Biochem. Biophys. 329, 113-122.
• Chang, C.Y., Wu, D.A., Lai, C.C., Miller, W.L. and Chung, B.C. (1988) Cloning and structure of the human adrenodoxin gene. DNA 7, 609-615.
• Chen, D., Lepar, G. and Kemper, B. (1994) A transcriptional regulatory element common to a large family of hepatic cytochrome P450 genes is a functional binding site of the orphan receptor HNF-4. J. Biol. Chem. 269, 5420-5427.
• Chen, D., Park, Y. and Kemper, B. (1994) Differential protein binding and transcriptional activities of HNF-4 elements in three closely related CYP2C genes. DNA Cell Biol. 13, 771-779.
• Chung, I. and Bresnick, E. (1995) Regulation of the constitutive expression of the human CYP1A2 gene: cis elements and their interactions with proteins. Mol. Pharmacol. 47, 677-685.
• Chung, B.C., Lai, C.C., Lin, C.H. and Chang, C.Y. (1989) Analysis of the human adrenodoxin promoter: evidence for its activity. Biochem. Biophys. Res. Commun. 159, 343-348.
• Clemens, J.W. Lala, D.S., Parker, K.L. and Richards, J.S. (1994) Steroidogenic factor-1 binding and transcriptional activity of the cholesterol side-chain cleavage promoter in rat granulosa cells. Endocrinology 134, 1499-1508.
• Crestani, M., Galli, G. and Chiang, J.Y. (1993) Genomic cloning, sequencing, and analysis of the hamster cholesterol 7-hydroxylase gene (CYP7). Arch. Biochem. Biophys. 306, 451-460.
• Damme, B., Darmer, D. and Pankow, D. (1996) Induction of hepatic cytochrome P4502E1 in rats by acetylsalicylic acid or sodium salicylate. Toxicology 106, 99-103.
• de Morais, S.M., Schweikl, H., Blaisdell, J. and Goldstein, J.A. (1993) Gene structure and upstream regulatory regions of human CYP2C9 and CYP2C18. Biochem. Biophys. Res. Commun. 194, 194-201.
• English, N., Hughes, V. and Wolf, C.R. (1994) Common pathways of cytochrome P450 gene regulation by peroxisome proliferators and barbiturates in Bacillus megaterium ATCC14581. J. Biol. Chem. 269, 26836-26841.
• English, N., Hughes, V. and Wolf, C.R. (1996) Induction of cytochrome P-450_BM-3 (CYP 102) by non-steroidal anti-inflammatory drugs in Bacillus megaterium. Biochem. J. 316, 279-283.
• Fasco, M.J., Treanor, C. and Kaminsky, L.S. (1996) Cytochrome P450 mRNA induction: Quantification by RNA-polymerase chain reaction using capillary electrophoresis. Methods Enzymol. 272, 401-412.
• Fournier, T., Mejdoubi, N., Lapoumeroulie, C., Hamelin, J., Elion, J., Durand, G. and Porquet, D. (1994) Transcriptional regulation of rat 1-acid glycoprotein gene by phenobarbital. J. Biol. Chem. 269, 27175-27178.
• Gaidamakova, E.K., Karginov, V.A. and Kovalenko, S.P. (1994) Protein-binding DNA regions inside and in the vicinity of the cytochrome P450bm-3 gene from Bacillus megaterium. Biochem. Biophys. Res. Commun. 198, 862-868.
• Ghosal, A., Sadrieh, N., Reik, L., Levin, W. and Thomas, P.E. (1996) Induction of the male-specific cytochrome P450 3A2 in female rats by phenytoin. Arch. Biochem. Biophys. 332, 153-162.
• Gonzalez, F.J. and Fernandez-Salguero, P. (1998) The aryl hydrocarbon receptor: studies using the AHR-null mice. Drug Metab. Dispos. 26, 1194-1198.
• Goodvin, B., Liddle, C., Murray, M., Tapner, M., Rooney, T. and Farrell, G.C. (1996) Effect of metyrapone on expression of CYPs 2C11, 3A2, and other 3A genes in rat hepatocytes cultured on matrigel. Biochem. Pharmacol. 52, 219-227.
• Hahn, M.E. (1998) The aryl hydrocarbon receptor: a comparative perspective. Comp. Biochem. Physiol. C 121, 23-53.
• He, J.S. and Fulco, A.J. (1991) A barbiturate-regulated protein binding to a common sequence in the cytochrome P450 genes of rodents and bacteria. J. Biol. Chem. 266, 7864-7869.
• He, J.S., Liang, Q. and Fulco, A.J. (1995) The molecular cloning and characterization of BM1P1 and BM1P2 proteins, putative positive transcription factors involved in barbiturate-mediated induction of the genes encoding cytochrome P450_BM-1 of Bacillus megaterium. J. Biol. Chem. 270, 18615-18625.
• Hopkins, N.E., English, N., Hughes, V., Rowley, C.W., Wolf, C.R. and Alworth, W.L. (1998) Induction of CYP102 (cytochrome P450BM-3) in Bacillus megaterium by 17ß-estradiol and 4-sec-butylphenol. Biochem. Biophys. Res. Commun. 244, 868-872 [published erratum Biochem. Biophys. Res. Commun. 246, 933 (1998)].
• Huss, J.M. and Kasper, C.B. (1998) Nuclear receptor involvement in the regulation of rat cytochrome P450 3A23 expression. J. Biol. Chem. 273, 16155-16162.
• Jeong, K.-S., Lee, I.J., Roberts, B.J., Soh, Y., Yoo, J.K., Lee, J.W. and Song, B.J. (1996) Transcriptional inhibition of cytochrome P4502E1 by a synthetic compound, YH439. Arch. Biochem. Biophys. 326, 137-144.
• Kim, J. and Kemper, B. (1997) Phenobarbital alters protein binding to the CYP2B1/2 phenobarbital-responsive unit in native chromatin. J. Biol. Chem. 272, 29423-29425.
• Kraner, J.C., Lasker, J.M., Corcoran, G.B., Ray, S.D. and Raucy, J.L. (1993) Induction of P4502E1 by acetone in isolated rabbit hepatocytes. Role of increased protein and mRNA synthesis. Biochem. Pharmacol 45, 1483-1492.
• Kress, S., Reichert, J. and Schwarz, M. (1998) Functional analysis of the human cytochrome P4501A1 (CYP1A1) gene enhancer. Eur. J. Biochem. 258, 803-812.
• Kurten, R.C. and Richards, J.S. (1989) An adenosine 3´5´-monophosphate-responsive deoxyribonucleic acid element confers forskolin sensitivity on gene expression by primary rat granulosa cells. Endocrinology 125, 1345-1357.
• Liang, Q. and Fulco, A.J. (1995) Transcriptional regulation of the genes encoding cytochromes P450_BM-1 and P450_BM-3 in Bacillus megaterium by the binding of Bm3R1 repressor to Barbie box elements and operator sites. J. Biol. Chem. 270, 18606-18614.
• Liang, Q., He, J.S. and Fulco, A.J. (1995) The role of Barbie box sequences as cis-acting elements involved in the barbiturate-mediated induction of cytochromes P450_BM-1 and P450_BM-3 in Bacillus megaterium. J. Biol. Chem. 270, 4438-4450.
• Liang, Q., Chen, L. and Fulco, A.J. (1998) In vivo roles of Bm3R1 repressor in the barbiturate-mediated induction of the cytochrome P450 genes (P450_BM-3 and P450_BM-1) of Bacillus megaterium. Biochim. Biophys. Acta 1380, 183-197.
• Luc, P.V., Adesnik, M., Ganguly, S. and Shaw, P.M. (1996) Transcriptional regulation of the CYP2B1 and CYP2B2 genes by C/EBP-related proteins. Biochem. Pharmacol. 51, 345-356.
• Lynch, J.P., Lala, D.S., Peluso, J.J., Luo, W., Parker, K.L. and White, B.A. (1993) Steroidogenic factor 1, an orphan nuclear receptor, regulates the expression of the rat aromatase gene in gonadal tissues. Mol. Endocrinol. 7, 776-786.
• Mahendroo, M.S., Mendelson, C.R. and Simpson, E.R. (1993) Tissue-specific and hormonally controlled alternative promoters regulate aromatase cytochrome P450 gene expression in human adipose tissue. J. Biol. Chem. 268, 19463-19470.
• Mason, J.I., Bird, I.M. and Rainey, W.E. (1995) Adrenal androgen biosynthesis with special attention to P450c17. Ann. N. Y. Acad. Sci. 774, 47-58.
• Means, G.D., Kilgore, M.W., Mahendroo, M.S., Mendelson, C.R. and Simpson, E.R. (1991) Tissue-specific promoters regulate aromatase cytochrome P450 gene expression in human ovary and fetal tissues. Mol. Endocrinol. 5, 2005-2013.
• Momoi, K., Waterman, M.R., Simpson, E.R. and Zanger, U.M. (1992) 3´,5´-cyclic adenosine monophosphate-dependent transcription of the CYP11A (cholesterol side chain cleavage cytochrome P450) gene involves a DNA response element containing a putative binding site for transcription factor Sp1. Mol. Endocrinol. 6, 1682-1690.
• Monté, D., DeWitte, F. and Hum, D.W. (1998) Regulation of the human P450scc gene by steroidogenic factor 1 is mediated by CBP/p300. J. Biol. Chem. 273, 4585-4591.
• Morgan, E.T., Nikolova-Karakashian, M., Chen, J.-q. and Merrill, A.H., Jr. (1996) Sphingolipid-dependent signaling in regulation of cytochrome P450 expression. Methods Enzymol. 272, 381-388.
• Morohashi, K., Hatano, O., Nomura, M., Takayama, K., Hara, M., Yoshii, H., Takakusu, A. and Omura, T. (1995) Function and distribution of a steroidogenic cell-specific transcription factor, Ad4BP. J. Steroid Biochem. Mol. Biol. 53, 81-88.
• Morris, D.L. and Davila, J.C. (1996) Analysis of rat cytochrome P450 isoenzyme expression using semi-quantitative reverse transcriptase-polymerase chain reaction (RT-PCR). Biochem. Pharmacol. 52, 781-792.
• Murayama, N., Shimada, M., Yamazoe, Y., Sogawa, K., Nakayama, K., Fujii-Kuriyama, Y. and Kato, R. (1996) Distinct effects of phenobarbital and its N-methylated derivative on liver cytochrome P450 induction. Arch. Biochem. Biophys. 328, 184-192.
• Nirodi, C.S., Sultana, S., Ram, N., Prabhu, L. and Padmanaban, G. (1996) Involvement of synthesis and phosphorylation of nuclear protein factors that bind to the positive cis-acting element in the transcriptional activation of the CYP2B1/B2 gene by phenobarbiton in vivo. Arch. Biochem. Biophys. 331, 79-86.
• Palmer, C.N.A., Axen, E., Hughes, V. and Wolf, C.R. (1998) The repressor protein, Bm3R1, mediates an adaptive response to toxic fatty acids in Bacillus megaterium. J. Biol. Chem. 273, 18109-18116.
• Pestell, R.G., Albanese, C., Watanabe, G., Johnson, J., Eklund, N., Lastowiecki, P. and Jameson, J.L. (1995) Epidermal growth factor and c-Jun act via a common DNA regulatory element to stimulate transcription of the ovine P-450 cholesterol side chain cleavage (CYP11A1) promoter. J. Biol. Chem. 270, 18301-18308.
• Omura, T. and Morohashi, K. (1995) Gene regulation of steroidogenesis. J. Steroid Biochem. Mol. Biol. 53, 19-25.
• Quattrochi, L.C. and Tukey, R.H. (1989) The human cytochrome Cyp1A2 gene contains regulatory elements responsive to 3-methylcholanthrene. Mol. Pharmacol. 36, 66-71.
• Quattrochi, L.C., Vu, T. and Tukey, R.H. (1994) The human CYP1A2 gene and induction by 3-methylcholanthrene. A region of DNA that supports Ah-receptor binding and promoter-specific induction. J. Biol. Chem. 269, 6949-6954.
• Raffalli-Mathieu, F., Geneste, O. and Lang, M.A. (1997) Characterization of two nuclear proteins that interact with cytochrome P-450 1A2 mRNA - Regulation of RNA binding and possible role in the expression of the Cyp1a2 gene. Eur. J. Biochem. 245, 17-24.
• Ram, P.A. and Waxman, D.J. (1992) Thyroid hormone stimulation of NADPH P450 reductase expression in liver and extrahepatic tissues. Regulation by multiple mechanisms. J. Biol. Chem. 267, 3294-3301.
• Sagami, I., Kikuchi, H., Ikawa, S. and Watanabe, M. (1994) Characterization of hamster CYP1A1 gene: inducible expression and negative regulation. J. Biochem. (Tokyo) 116, 801-810.
• Schuetz, J.D., Schuetz, E.G., Thottassery, J.V., Guzelian, P.S., Strom, S. and Sun, D. (1996) Identification of a novel dexamethasone responsive enhancer in the human CYP3A5 gene and its activation in human and rat liver cells. Mol. Pharmacol. 49, 63-72.
• Shaw, G.C. and Fulco, A.J. (1992) Barbiturate-mediated regulation of expression of the cytochrome P450_BM-3 gene of Bacillus megaterium by Bm3R1 protein. J. Biol. Chem. 267, 5515-5526.
• Shaw, G.C. and Fulco, A.J. (1993) Inhibition by barbiturates of the binding of Bm3R1 repressor to its operator site on the barbiturate-inducible cytochrome P450_BM-3 gene of Bacillus megaterium. J. Biol. Chem. 268, 2997-3004.
• Shaw, P.M., Edigkaufer, M., Doehmer, J. and Adesnik, M. (1996) Sequence of the rat PB-inducible CYP2B1 promoter. Biochim. Biophys. Acta 1305, 54-58.
• Sidhu, J.S. and Omiecinski, C.J. (1998) Protein synthesis inhibitors exhibit a nonspecific effect on phenobarbital-inducible cytochome P450 gene expression in primary rat hepatocytes. J. Biol. Chem. 273, 4769-4775.
• Simpson, E.R., Mahendroo, M.S., Means, G.D., Kilgore, M.W., Corbin, C.J. and Mendelson, C.R. (1993a) Tissue-specific promoters regulate aromatase cytochrome P450 expression. Clin. Chem. 39, 317-324.
• Simpson, E.R., Mahendroo, M.S., Means, G.D., Kilgore, M.W., Corbin, C.J. and Mendelson, C.R. (1993b) Tissue-specific promoters regulate aromatase cytochrome P450 expression. J. Steroid Biochem. Mol. Biol. 44, 321-330.
• Strom, S.C., Pisarov, L.A., Dorko, K., Thompson, M.T., Schuetz, J.D. and Schuetz, E.G. (1996) Use of human hepatocytes to study P450 gene induction. Methods Enzymol. 272, 388-401.
• Stromstedt, M., Rozman, D. and Waterman, M.R. (1996) The ubiquitously expressed human CYP51 encodes lanosterol 14-demethylase, a cytochrome P450 whose expression is regulated by oxysterols. Arch. Biochem. Biophys. 329, 73-81.
• Subramanian, A., Wang, J. and Gil, G. (1998) STAT 5 and NF-Y are involved in expression and growth hormone-mediated sexually dimorphic regulation of cytochrome P450 3A10/lithocholic acid 6ß-hydroxylase. Nucleic Acids Res. 26, 2173-2178.
• Sundseth, S.S., Alberta, J.A. and Waxman, D.J. (1992) Sex-specific, growth hormone-regulated transcription of the cytochrome P450 2C11 and 2C12 genes. J. Biol. Chem. 267, 3907-3914.
• Takata, Y., Sagara, Y., Kono, A., Sekimizu, K. and Horiuchi, T. (1993) Gene structure of bovine adrenodoxin reductase. Biol. Pharm. Bull. 16, 1200-1206.
• Toda, K., Yang, L.X. and Shizuta, Y. (1995) Transcriptional regulation of the human aromatase cytochrome P450 gene expression in human placental cells. J. Steroid Biochem. Mol. Biol. 53, 181-190.
• Toda, K., Nomoto, S. and Shizuta, Y. (1996) Identification and characterization of transcriptional regulatory elements of the human aromatase cytochrome P450 gene (CYP19). J. Steroid Biochem. Mol. Biol. 56, 151-159.
• Trottier, E., Belzil, A., Stoltz, C. and Anderson, A. (1995) Localization of a phenobarbital-responsive element (PBRE) in the 5´-flanking region of the rat CYP2B2 gene. Gene 158, 263-268.
• Venepally, P., Chen, D. and Kemper, B. (1992) Transcriptional regulatory elements for basal expression of cytochrome P450IIC genes. J. Biol. Chem. 267, 17333-17338.
• Vieira, I., Sonnier, M. and Cresteil, T. (1996) Developmental expression of CYP2E1 in the human liver. Hypermethylation control of gene expression during the neonatal period. Eur. J. Biochem. 238, 476-483.
• Weisz, A., Cicatiello, L. and Esumi, H. (1996) Regulation of the mouse inducible-type nitric oxide synthase gene promoter by interferon-, bacterial lipopolysaccharide and N^G-monomethyl-L-arginine. Biochem. J. 316, 209-215.
• Wen, L.P., Ruettinger, R.T. and Fulco, A.J. (1989) Requirement for a 1-kilobase 5´-flanking sequence for barbiturate-inducible expression of the cytochrome P-450_BM-3 gene in Bacillus megaterium. J. Biol. Chem. 264, 10996-11003.
• Yanagawa, Y., Chen, J.C., Hsu, L.C. and Yoshida, A. (1995) The transcriptional regulation of human aldehyde dehydrogenase I gene. The structural and functional analysis of the promoter. J. Biol. Chem. 270, 17521-17527.
• Yeh, J.R., Huang, C., Wu, D.A., Guo, I.C., Rainey, W.E. and Chung, B.C. (1995) Regulation of ferredoxin gene in steroidogenic and nonsteroidogenic cells. J. Steroid Biochem. Mol. Biol. 53, 47-51.
• Yuan, W., Serron, S.C., Haddican, M.M., Cawley, G.F., Eyer, C.S. and Backes, W.L. (1997) Ethylbenzene modulates the expression of different cytochromes P-450 isozymes by discrete multistep process. Biochim. Biophys. Acta 1334, 361-372.
• Zaphiropoulos, P.G., Westin, S., Strom, A., Mode, A. and Gustafsson, J.-Å. (1990) Structural and regulatory analysis of a cytochrome P450 gene (CYP2C12) expressed predominantly in female rat liver. DNA Cell Biol. 9, 49-56.
• Zhang, P. and Mellon, S.H. (1996) The orphan nuclear receptor steroidogenic factor-1 regulates the cyclic adenosine 3´,5´-monophosphate-mediated transcriptional activation of rat cytochrome P450c17 (17-hydroxylase/c17-20 lyase). Mol. Endocrinol. 10, 147-158.
• Zhang, P., Rodriguez, H. and Mellon, S.H. (1995) Transcriptional regulation of P450scc gene expression in neural and steroidogenic cells: implications for regulation of neurosteroidogenesis. Mol. Endocrinol. 9, 1571-1582.

Back to the Directory of P450-containing Systems home page:

Trieste site

Gödöllõ site