List of P450-dependent reactions of steroid biosynthesis and metabolism

Compiled by Kirill Degtyarenko

Last modified: Tue Jul 6 15:53:39 BST 2004


    C1

  1. Steroid alpha-hydroxylation at C1

    C2

  2. Steroid hydroxylation at C2
  3. Steroid 2ß-hydroxylation at C2

    C4

  4. Steroid hydroxylation at C4

    C6

  5. Steroid ß-hydroxylation at C6

    C7

  6. Steroid alpha-hydroxylation at C7
  7. Steroid ß-hydroxylation at C7

    C11

  8. Steroid alpha-hydroxylation at C11
  9. Steroid ß-hydroxylation at C11

    C14

  10. Steroid alpha-hydroxylation at C14
  11. Sterol 14alpha-demethylase

    C15

  12. Steroid alpha-hydroxylation at C15

    C16

  13. Steroid alpha-hydroxylation at C16
  14. Steroid ß-hydroxylation at C16

    C17

  15. Steroid alpha-hydroxylation at C17
  16. Cleavage of steroid C17-C20 bond

    C18

  17. Steroid hydroxylation at C18
  18. Steroid oxidation at C18

    C19

  19. Aromatase (aromatisation of the A ring and C19 demethylation)
  20. Steroid hydroxylation at C19
  21. Steroid oxidation at C19

    C21

  22. Steroid hydroxylation at C21

    C22

  23. Cholesterol side-chain cleavage (hydroxylation at C22 and C20 and cleavage of C20-C22 bond)

    C24

  24. Sterol hydroxylation at C24

    C25

  25. Sterol hydroxylation at C25

    C27

  26. Sterol hydroxylation at C27
  27. Sterol oxidation at C27

See also List of steroid ligands of P450s


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