List of steroid ligands of P450s

Substrates and products

Compiled by Kirill Degtyarenko

Last modified: Tue Jul 6 15:53:48 BST 2004


  1. Aldosterone (11ß,21-dihydroxy-3,20-dioxopregn-4-en-18-al)
  2. Androstenedione (Androst-4-ene-3,17-dione)
  3. 5ß-Cholestane-3alpha,7alpha,12alpha,27-tetrol
  4. 5ß-Cholestane-3alpha,7alpha,12alpha-triol
  5. Cholesterol (Cholest-5-en-3ß-ol)
  6. Corticosterone (11ß,21-Dihydroxypregn-4-ene-3,20-dione; Kendall's compound B)
  7. Cortisol (11ß,17,21-Trihydroxypregn-4-ene-3,20-dione; Cortisol; Hydrocortisone; Kendall's compound F)
  8. Dehydroepiandrosterone (Dehydroepiandrosterone; Dehydroisoandrosterone; trans-Dehydroandrosterone; DHEA; 3ß-Hydroxyandrost-5-en-17-one; Prasterone)
  9. 11-Deoxycorticosterone (21-Hydroxypregn-4-ene-3,20-dione; Deoxycorticosterone; 11-Desoxycorticosterone; Desoxycortone; DOC; 21-Hydroxyprogesterone; Kendall's desoxy compound B)
  10. 11-Deoxycortisol (17alpha,21-Dihydroxypregn-4-ene-3,20-dione)
  11. 21-Deoxycortisol (11ß,17alpha,-Dihydroxypregn-4-ene-3,20-dione)
  12. 22,23-Dihydroergosterol (Ergosta-5,7-dien-3ß-ol)
  13. 18,19-Dihydroxydeoxycorticosterone (18,19,21-Trihydroxypregn-4-ene-3,20-dione)
  14. 7alpha,14alpha-Dihydroxyprogesterone (7alpha,14alpha-Dihydroxypregn-4-ene-3,20-dione)
  15. 11ß,14alpha-Dihydroxyprogesterone (11ß,14alpha-Dihydroxypregn-4-ene-3,20-dione)
  16. 1alpha,25-Dihydroxyvitamin D3 (Calcitriol; 1alpha,25-Dihydroxycholecalciferol)
  17. 24,25-Dihydroxyvitamin D3 (24,25-Dihydroxycholecalciferol)
  18. 4,4'-Dimethylcholestatrienol (4,4'-Dimethylcholesta-8,14,24-trien-3ß-ol)
  19. Ecdysone (alpha-Ecdysone; (22R)-2ß,3ß,14alpha,22,25-Pentahydroxycholest-7-en-6-one)
  20. Ergosterol ([22E]-Ergosta-5,7,22-trien-3ß-ol)
  21. Estradiol (Estradiol-17ß; Estra-1,3,5[10]-triene-3,17ß-diol; Oestradiol; Oestradiol-17ß)
  22. Estrone (3ß-Hydroxyestra-1,3,5[10]-triene-17-one)
  23. 6ß-Hydroxyandrostenedione (6ß-Hydroxyandrost-4-ene-3,17-dione)
  24. 11ß-Hydroxyandrostenedione (11ß-Hydroxyandrost-4-ene-3,17-dione)
  25. 15alpha-Hydroxyandrostenedione (15alpha-Hydroxyandrost-4-ene-3,17-dione)
  26. 16alpha-Hydroxyandrostenedione (16alpha-Hydroxyandrost-4-ene-3,17-dione)
  27. 16ß-Hydroxyandrostenedione (16ß-Hydroxyandrost-4-ene-3,17-dione)
  28. 19-Hydroxyandrostenedione (19-Hydroxyandrost-4-ene-3,17-dione)
  29. 7alpha-Hydroxycholesterol (Cholest-5-ene-3ß,7alpha-diol)
  30. 18-Hydroxycorticosterone (11ß,18,21-Trihydroxypregn-4-ene-3,20-dione)
  31. 18-Hydroxycortisol (11ß,17alpha,18,21-Tetrahydroxypregn-4-ene-3,20-dione)
  32. 18-Hydroxydeoxycorticosterone (18,21-Dihydroxypregn-4-ene-3,20-dione)
  33. 19-Hydroxydeoxycorticosterone (19,21-Dihydroxypregn-4-ene-3,20-dione)
  34. 20-Hydroxyecdysone (ß-Ecdysone; Ecdysterone; 2ß,3ß,14alpha,20ß,22,25-Hexahydroxycholest-7-en-6-one; Insect moulting hormone; Polypodine A)
  35. 2-Hydroxyestradiol (Estra-1,3,5[10]-triene-2,3,17ß-triol)
  36. 4-Hydroxyestradiol (Estra-1,3,5[10]-triene-4,3,17ß-triol)
  37. 6ß-Hydroxylithocholic acid (3alpha,6ß-Dihydroxy-5ß-cholan-24-oic acid)
  38. 7ß-Hydroxypregnenolone (3ß,7ß-Dihydroxypregn-5-en-20-on)
  39. 17alpha-Hydroxypregnenolone (3ß,17alpha-Dihydroxypregn-5-en-20-on)
  40. 6ß-Hydroxyprogesterone (6ß-Hydroxypregn-4-ene-3,20-dione)
  41. 11ß-Hydroxyprogesterone (11ß-Hydroxypregn-4-ene-3,20-dione)
  42. 14alpha-Hydroxyprogesterone (14alpha-Hydroxypregn-4-ene-3,20-dione)
  43. 16alpha-Hydroxyprogesterone (16alpha-Hydroxypregn-4-ene-3,20-dione)
  44. 17alpha-Hydroxyprogesterone (17alpha-Hydroxypregn-4-ene-3,20-dione)
  45. 2ß-Hydroxytestosterone (2ß,17ß-Dihydroxyandrost-4-en-3-one)
  46. 6ß-Hydroxytestosterone (6ß,17ß-Dihydroxyandrost-4-en-3-one)
  47. 7alpha-Hydroxytestosterone (7alpha,17ß-Dihydroxyandrost-4-en-3-one)
  48. 11alpha-Hydroxytestosterone (11alpha,17ß-Dihydroxyandrost-4-en-3-one)
  49. 11ß-Hydroxytestosterone (11ß,17ß-Dihydroxyandrost-4-en-3-one)
  50. 15alpha-Hydroxytestosterone (15alpha,17ß-Dihydroxyandrost-4-en-3-one)
  51. 16alpha-Hydroxytestosterone (16alpha,17ß-Dihydroxyandrost-4-en-3-one)
  52. 16ß-Hydroxytestosterone (16ß,17ß-Dihydroxyandrost-4-en-3-one)
  53. 25-Hydroxyvitamin D3 (Calcidiol; 25-Hydroxycholecalciferol)
  54. Lanosterol (Kryptosterol; Lanosta-8,24-dien-3ß-ol)
  55. Lithocholic acid (3alpha-Hydroxy-5ß-cholan-24-oic acid)
  56. 19-Oic-deoxycorticosterone (21-Hydroxy-3,20-dioxopregn-4-en-19-oic acid)
  57. 18-Oxocortisol (11ß,17,21-Trihydroxypregn-4-ene-3,18,20-trione)
  58. 19-Oxo-deoxycorticosterone (21-Hydroxy-19-oxopregn-4-ene-3,20-dione)
  59. Pregnenolone (3ß-Hydroxypregn-5-en-20-one)
  60. Progesterone (Pregn-4-ene-3,20-dione)
  61. Testosterone (17ß-Hydroxyandrost-4-en-3-one)
  62. 3alpha,7alpha,12alpha-Trihydroxy-5ß-cholestan-27-oic acid
  63. 1alpha,24,25-Trihydroxyvitamin D3 (Calcitetrol; 1alpha,24,25-Trihydroxycholecalciferol)
  64. Vitamin D3 (Activated 7-dehydrocholesterol; Calciol; Cholecalciferol)

See also List of P450-dependent reactions of steroid biosynthesis and metabolism


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